Summary: SSXT protein (N-terminal region)
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The SSXT or SS18 protein is involved in synovial sarcoma in humans. A SYT-SSX fusion gene resulting from the chromosomal translocation t(X;18) (p11;q11) is characteristic of synovial sarcomas. This translocation fuses the SSXT (SYT) gene from chromosome 18 to either of two homologous genes at Xp11, SSX1 or SSX2 .
Xie Y, Skytting B, Nilsson G, Grimer RJ, Mangham CD, Fisher C, Shipley J, Bjerkehagen B, Myklebost O, Larsson O; , Oncogene 2002;21:5791-5796.: The SYT-SSX1 fusion type of synovial sarcoma is associated with increased expression of cyclin A and D1. A link between t(X;18)(p11.2; q11.2) and the cell cycle machinery. PUBMED:12173050 EPMC:12173050
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This tab holds annotation information from the InterPro database.
InterPro entry IPR007726
SSXT (also known as SS18) appears to function synergistically with RBM14 as a transcriptional coactivator [PUBMED:15919756].
The SSXT protein is involved in synovial sarcoma in humans. A SYT-SSX fusion gene resulting from the chromosomal translocation t(X;18) (p11;q11) is characteristic of synovial sarcomas. This translocation fuses the SSXT (SYT) gene from chromosome 18 to either of two homologous genes at Xp11, SSX1 or SSX2 [PUBMED:12173050].
The SS18 family also includes SS18-like proteins 1 and 2, and GRF1-interacting factors from plants [PUBMED:19648231]. SS18-like protein 1 is transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons [PUBMED:14716005, PUBMED:19081374].
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Curation and family details
|Seed source:||Pfam-B_4900 (release 7.6)|
|Number in seed:||26|
|Number in full:||570|
|Average length of the domain:||59.10 aa|
|Average identity of full alignment:||49 %|
|Average coverage of the sequence by the domain:||19.48 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 80369284 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||8|
|Download:||download the raw HMM for this family|
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