Summary: Caleosin related protein
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This family contains plant proteins related to caleosin. Caleosins contain calcium-binding domains and have an oleosin-like association with lipid bodies. Caleosins are present at relatively low levels and are mainly bound to microsomal membrane fractions at the early stages of seed development. As the seeds mature, overall levels of caleosins increased dramatically and they were associated almost exclusively with storage lipid bodies . This family is probably related to EF hands PF00036.
Murphy DJ, Hernendez-Pinzon I, Patel K, Hope RG, McLauchlan J; , Biochem Soc Trans 2000;28:710-711.: New insights into the mechanisms of lipid-body biogenesis in plants and other organisms. PUBMED:11171180 EPMC:11171180
Internal database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR007736
Caleosins are a family of lipid-associated proteins that are ubiquitous in plants and true fungi. In plants, caleosinss are Ca(2+)-binding oil-body surface proteins [PUBMED:16961733]. Later, caleosin was identified as a putative peroxygenase, which is involved in oxylipin metabolism during biotic and abiotic stress responses in Arabidopsis [PUBMED:19467604]. The calcium binding domain is probably related to the calcium-binding EF-hands motif INTERPRO.
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This example describes an architecture with one
Gladomain, followed by two consecutive
EGFdomains, and finally a single
- the UniProt description of the protein sequence
- the number of residues in the sequence
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The EF hand is a calcium binding domain found in a wide variety of proteins .
The clan contains the following 23 members:Ca_chan_IQ Caleosin Cbl_N2 DAG_kinase_N Dockerin_1 EF-hand_1 EF-hand_10 EF-hand_11 EF-hand_2 EF-hand_3 EF-hand_4 EF-hand_5 EF-hand_6 EF-hand_7 EF-hand_8 EF-hand_9 EF-hand_like EFhand_Ca_insen IQ IQCJ-SCHIP1 p25-alpha S_100 SPARC_Ca_bdg
We make a range of alignments for each Pfam-A family:
- the curated alignment from which the HMM for the family is built
- the alignment generated by searching the sequence database using the HMM
- Representative Proteomes (RPs) at 15%, 35%, 55% and 75% co-membership thresholds
- alignment generated by searching the UniProtKB sequence database using the family HMM
- alignment generated by searching the NCBI sequence database using the family HMM
- alignment generated by searching the metagenomics sequence database using the family HMM
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1Cannot generate PP/Heatmap alignments for seeds; no PP data available
Key: available, not generated, — not available.
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Curation and family details
|Seed source:||Pfam-B_5163 (release 7.7)|
|Number in seed:||121|
|Number in full:||794|
|Average length of the domain:||153.70 aa|
|Average identity of full alignment:||41 %|
|Average coverage of the sequence by the domain:||65.32 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 26740544 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||12|
|Download:||download the raw HMM for this family|
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