Summary: N-acetylglucosaminyltransferase II (MGAT2)
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N-acetylglucosaminyltransferase II (MGAT2) Provide feedback
UDP-N-acetyl-D-glucosamine:alpha-6-D-mannoside beta-1,2-N- acetylglucosaminyltransferase II (EC 18.104.22.168) (GnT II/MGAT2) is a Golgi resident enzyme that catalyses an essential step in the biosynthetic pathway leading from high mannose to complex N-linked oligosaccharides . Mutations in the MGAT2 gene lead to congenital disorder of glycosylation (CDG IIa). CDG IIa patients have an increased bleeding tendency, unrelated to coagulation factors .
D'Agostaro GA, Zingoni A, Moritz RL, Simpson RJ, Schachter H, Bendiak B; , J Biol Chem 1995;270:15211-15221.: Molecular cloning and expression of cDNA encoding the rat UDP-N-acetylglucosamine:alpha-6-D-mannoside beta-1,2-N-acetylglucosaminyltransferase II. PUBMED:7797505 EPMC:7797505
Van Geet C, Jaeken J, Freson K, Lenaerts T, Arnout J, Vermylen J, Hoylaerts MF; , J Inherit Metab Dis 2001;24:477-492.: Congenital disorders of glycosylation type Ia and IIa are associated with different primary haemostatic complications. PUBMED:11596651 EPMC:11596651
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR007754
N-acetylglucosaminyltransferase II (EC) is a Golgi resident enzyme that catalyzes an essential step in the biosynthetic pathway leading from high mannose to complex N-linked oligosaccharides [PUBMED:7797505]. Mutations in the MGAT2 gene lead to a congenital disorder of glycosylation (CDG IIa). CDG IIa patients have an increased bleeding tendency, unrelated to coagulation factors [PUBMED:11596651].
Synonym(s): UDP-N-acetyl-D-glucosamine:alpha-6-D-mannoside beta-1,2-N- acetylglucosaminyltransferase II, GnT II/MGAT2.
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
|Cellular component||Golgi stack (GO:0005795)|
|integral to membrane (GO:0016021)|
|Molecular function||alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity (GO:0008455)|
|Biological process||oligosaccharide biosynthetic process (GO:0009312)|
- the number of sequences which exhibit this architecture
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This is the GT-A clan that contains diverse glycosyltransferases that possess a Rossmann like fold .
The clan contains the following 44 members:Anp1 Caps_synth Cellulose_synt CgtA CHGN Chitin_synth_1 Chitin_synth_2 CofC CTP_transf_3 DUF2064 DUF273 DUF604 Fringe Galactosyl_T GlcNAc Gly_transf_sug Glyco_tranf_2_2 Glyco_tranf_2_3 Glyco_tranf_2_4 Glyco_tranf_2_5 Glyco_trans_2_3 Glyco_transf_21 Glyco_transf_25 Glyco_transf_34 Glyco_transf_43 Glyco_transf_49 Glyco_transf_6 Glyco_transf_64 Glyco_transf_7C Glyco_transf_7N Glyco_transf_8 Glyco_transf_92 Glycos_transf_2 GNT-I IspD Mannosyl_trans3 MGAT2 NTP_transf_3 NTP_transferase Nucleotid_trans Pox_P35 Rhamno_transf TcdA_TcdB UDPGP
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Curation and family details
|Seed source:||Pfam-B_6001 (release 7.7)|
|Number in seed:||10|
|Number in full:||200|
|Average length of the domain:||274.60 aa|
|Average identity of full alignment:||35 %|
|Average coverage of the sequence by the domain:||75.24 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||9|
|Download:||download the raw HMM for this family|
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