Summary: Suppressor of fused protein (SUFU)
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This is the Wikipedia entry entitled "Suppressor of fused Sufu protein N terminal domain". More...
Suppressor of fused Sufu protein N terminal domain Edit Wikipedia article
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Suppressor of fused protein (SUFU) Provide feedback
SUFU, encoding the human orthologue of Drosophila suppressor of fused, appears to have a conserved role in the repression of Hedgehog signaling. SUFU exerts its repressor role by physically interacting with GLI proteins in both the cytoplasm and the nucleus [1]. SUFU has been found to be a tumour-suppressor gene that predisposes individuals to medulloblastoma by modulating the SHH signaling pathway [2]. Genomic contextual analysis of bacterial SUFU versions revealed that they are immunity proteins against diverse nuclease toxins in polymorphic toxin systems [3].
Literature references
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Rubin JB, Rowitch DH; , Cancer Cell 2002;2:7-8.: Medulloblastoma: A problem of developmental biology. PUBMED:12150819 EPMC:12150819
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Taylor MD, Liu L, Raffel C, Hui CC, Mainprize TG, Zhang X, Agatep R, Chiappa S, Gao L, Lowrance A, Hao A, Goldstein AM, Stavrou T, Scherer SW, Dura WT, Wainwright B, Squire JA, Rutka JT, Hogg D; , Nat Genet 2002;31:306-310.: Mutations in SUFU predispose to medulloblastoma. PUBMED:12068298 EPMC:12068298
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Zhang D, Iyer LM, Aravind L;, Nucleic Acids Res. 2011;39:4532-4552.: A novel immunity system for bacterial nucleic acid degrading toxins and its recruitment in various eukaryotic and DNA viral systems. PUBMED:21306995 EPMC:21306995
This tab holds annotation information from the InterPro database.
InterPro entry IPR020941
Sufu, encoding the human ortholog of Drosophila suppressor of fused, appears to have a conserved role in the repression of Hedgehog signalling. It is a repressor of the Gli and Ci transcription factors of the Hedgehog signalling cascade [ PUBMED:12150819 ], and functions by binding these proteins and preventing their translocation to the nucleus. Sufu has been found to be a tumour-suppressor gene that predisposes individuals to medulloblastoma by modulating the SHH signalling pathway [ PUBMED:12068298 ]. Homologues of Sufu have been found in bacteria, though their function is not currently known.
This entry represents a domain found in Sufu and its homologues. It is also found in other proteins that are functionally uncharacterised. In eukaryotic Sufu, an additional domain ( ) is found at the C terminus of the protein. This domain binds to the C-terminal domain of the Gli/Ci transcription factors, inhibiting their activity [ PUBMED:15367681 ].
Domain organisation
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Alignments
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Seed (112) |
Full (2207) |
Representative proteomes | UniProt (7986) |
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RP15 (240) |
RP35 (884) |
RP55 (2154) |
RP75 (3803) |
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PP/heatmap | 1 |
1Cannot generate PP/Heatmap alignments for seeds; no PP data available
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Seed (112) |
Full (2207) |
Representative proteomes | UniProt (7986) |
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RP15 (240) |
RP35 (884) |
RP55 (2154) |
RP75 (3803) |
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Raw Stockholm | |||||||
Gzipped |
You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.
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Curation and family details
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Curation
Seed source: | Pfam-B_6089 (release 7.7) |
Previous IDs: | none |
Type: | Family |
Sequence Ontology: | SO:0100021 |
Author: |
Moxon SJ |
Number in seed: | 112 |
Number in full: | 2207 |
Average length of the domain: | 162.00 aa |
Average identity of full alignment: | 23 % |
Average coverage of the sequence by the domain: | 50.20 % |
HMM information
HMM build commands: |
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
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Model details: |
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Model length: | 173 | ||||||||||||
Family (HMM) version: | 15 | ||||||||||||
Download: | download the raw HMM for this family |
Species distribution
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Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the SUFU domain has been found. There are 29 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.
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