# STOCKHOLM 1.0 #=GF ID SUFU #=GF AC PF05076.14 #=GF DE Suppressor of fused protein (SUFU) #=GF AU Moxon SJ;0000-0003-4644-1816 #=GF SE Pfam-B_6089 (release 7.7) #=GF GA 21.00 21.00; #=GF TC 21.10 21.00; #=GF NC 20.90 20.70; #=GF BM hmmbuild HMM.ann SEED.ann #=GF SM hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq #=GF TP Family #=GF WK Suppressor_of_fused_Sufu_protein_N_terminal_domain #=GF RN [1] #=GF RM 12150819 #=GF RT Medulloblastoma: A problem of developmental biology. #=GF RA Rubin JB, Rowitch DH; #=GF RL Cancer Cell 2002;2:7-8. #=GF RN [2] #=GF RM 12068298 #=GF RT Mutations in SUFU predispose to medulloblastoma. #=GF RA Taylor MD, Liu L, Raffel C, Hui CC, Mainprize TG, Zhang X, #=GF RA Agatep R, Chiappa S, Gao L, Lowrance A, Hao A, Goldstein AM, #=GF RA Stavrou T, Scherer SW, Dura WT, Wainwright B, Squire JA, Rutka #=GF RA JT, Hogg D; #=GF RL Nat Genet 2002;31:306-310. #=GF RN [3] #=GF RM 21306995 #=GF RT A novel immunity system for bacterial nucleic acid degrading #=GF RT toxins and its recruitment in various eukaryotic and DNA viral #=GF RT systems. #=GF RA Zhang D, Iyer LM, Aravind L; #=GF RL Nucleic Acids Res. 2011;39:4532-4552. #=GF DR INTERPRO; IPR020941; #=GF DR SO; 0100021; polypeptide_conserved_region; #=GF CC SUFU, encoding the human orthologue of Drosophila suppressor of #=GF CC fused, appears to have a conserved role in the repression of #=GF CC Hedgehog signaling. SUFU exerts its repressor role by physically #=GF CC interacting with GLI proteins in both the cytoplasm and the #=GF CC nucleus [1]. SUFU has been found to be a tumour-suppressor gene #=GF CC that predisposes individuals to medulloblastoma by modulating #=GF CC the SHH signaling pathway [2]. Genomic contextual analysis of #=GF CC bacterial SUFU versions revealed that they are immunity proteins #=GF CC against diverse nuclease toxins in polymorphic toxin systems #=GF CC [3]. #=GF SQ 120 #=GS Q97IJ6_CLOAB/222-390 AC Q97IJ6.1 #=GS D2R4H9_PIRSD/235-402 AC D2R4H9.1 #=GS W8F634_9BACT/62-240 AC W8F634.1 #=GS C7M5I2_CAPOD/273-450 AC C7M5I2.1 #=GS Q8P464_XANCP/57-231 AC Q8P464.1 #=GS E6WVC7_PSEUU/59-233 AC E6WVC7.1 #=GS F9ZWS5_METMM/58-232 AC F9ZWS5.1 #=GS E8MYR9_ANATU/63-237 AC E8MYR9.1 #=GS H6NDD8_9BACL/57-233 AC H6NDD8.1 #=GS C6D1U7_PAESJ/34-208 AC C6D1U7.1 #=GS R0A527_9FIRM/70-248 AC R0A527.1 #=GS C0Z5Z2_BREBN/29-206 AC C0Z5Z2.1 #=GS R7KPI5_9FIRM/54-246 AC R7KPI5.1 #=GS R5ALS1_9FIRM/59-237 AC R5ALS1.1 #=GS R6R513_9FIRM/63-238 AC R6R513.1 #=GS C6XLV0_HIRBI/49-225 AC C6XLV0.1 #=GS G8T6W9_NIAKG/29-194 AC G8T6W9.1 #=GS Q9I6N8_PSEAE/41-196 AC Q9I6N8.1 #=GS A0A384K9H2_YERPE/199-363 AC A0A384K9H2.1 #=GS D8MQ03_ERWBE/197-361 AC D8MQ03.1 #=GS Q8EYV4_LEPIN/197-371 AC Q8EYV4.1 #=GS B0SQ97_LEPBP/196-376 AC B0SQ97.1 #=GS Q1DFH8_MYXXD/63-224 AC Q1DFH8.1 #=GS Q4KDX4_PSEF5/53-218 AC Q4KDX4.1 #=GS Q8CMI1_SHEON/46-204 AC Q8CMI1.1 #=GS R7GC25_9CLOT/42-205 AC R7GC25.1 #=GS Q8DWK9_STRMU/68-232 AC Q8DWK9.1 #=GS I3ZXL0_ORNRL/52-226 AC I3ZXL0.1 #=GS H8KXR3_SOLCM/47-216 AC H8KXR3.1 #=GS C7PA06_CHIPD/47-216 AC C7PA06.1 #=GS H1Z7P6_MYROD/47-214 AC H1Z7P6.1 #=GS D5ST45_PLAL2/47-215 AC D5ST45.1 #=GS H1YBR1_9SPHI/87-250 AC H1YBR1.1 #=GS H1YC16_9SPHI/47-215 AC H1YC16.1 #=GS F0RD43_CELLC/48-212 AC F0RD43.1 #=GS D9SU31_CLOC7/51-215 AC D9SU31.1 #=GS R5AT21_9FIRM/51-215 AC R5AT21.1 #=GS R7H1N5_9FIRM/51-213 AC R7H1N5.1 #=GS J7L1X9_NOCAA/84-246 AC J7L1X9.1 #=GS D7B9H8_NOCDD/35-197 AC D7B9H8.1 #=GS C0ZD96_BREBN/72-236 AC C0ZD96.1 #=GS D3EDK5_GEOS4/39-203 AC D3EDK5.1 #=GS R6Q3F1_9FIRM/37-200 AC R6Q3F1.1 #=GS D0IVN9_COMT2/51-220 AC D0IVN9.1 #=GS H9JRL8_BOMMO/87-271 AC H9JRL8.1 #=GS Q17FL2_AEDAE/52-234 AC Q17FL2.1 #=GS B4M095_DROVI/49-241 AC B4M095.1 #=GS B4NI11_DROWI/52-243 AC B4NI11.1 #=GS B3M1W5_DROAN/50-239 AC B3M1W5.1 #=GS B4QS75_DROSI/48-237 AC B4QS75.1 #=GS H2YPK1_CIOSA/34-210 AC H2YPK1.1 #=GS K1Q903_CRAGI/57-237 AC K1Q903.1 #=GS G3NWC3_GASAC/53-229 AC G3NWC3.1 #=GS W4XDB0_STRPU/52-229 AC W4XDB0.1 #=GS W4XXP5_STRPU/31-205 AC W4XXP5.1 #=GS A0A1X7VXQ0_AMPQE/45-216 AC A0A1X7VXQ0.1 #=GS A7SLZ8_NEMVE/42-229 AC A7SLZ8.1 #=GS E0VUP1_PEDHC/53-229 AC E0VUP1.1 #=GS E9FSV5_DAPPU/76-255 AC E9FSV5.1 #=GS T1I0U2_RHOPR/44-222 AC T1I0U2.1 #=GS K7J9A3_NASVI/77-263 AC K7J9A3.1 #=GS F4WTN0_ACREC/63-239 AC F4WTN0.1 #=GS E2BJT6_HARSA/79-255 AC E2BJT6.1 #=GS K0F935_9NOCA/36-201 AC K0F935.1 #=GS D8J272_HERSS/81-245 AC D8J272.1 #=GS D1ANL7_SEBTE/66-229 AC D1ANL7.1 #=GS Q0AP68_MARMM/35-202 AC Q0AP68.1 #=GS A4F753_SACEN/29-181 AC A4F753.1 #=GS Q9FBK0_STRCO/29-193 AC Q9FBK0.1 #=GS E4NGL4_KITSK/51-210 AC E4NGL4.1 #=GS E3ITQ4_FRAIE/28-207 AC E3ITQ4.1 #=GS A8L2G2_FRASN/38-204 AC A8L2G2.1 #=GS Q0RCX5_FRAAA/31-197 AC Q0RCX5.1 #=GS V9XMU9_9NOCA/34-192 AC V9XMU9.1 #=GS F1TJG7_RHOHA/31-190 AC F1TJG7.1 #=GS D5UW29_TSUPD/33-194 AC D5UW29.1 #=GS F6EPB7_HOYSD/32-189 AC F6EPB7.1 #=GS A0A1N3K152_9MYCO/35-196 AC A0A1N3K152.1 #=GS A1TDK8_MYCVP/34-192 AC A1TDK8.1 #=GS A0R2B9_MYCS2/34-196 AC A0R2B9.1 #=GS V5XG59_MYCNE/34-192 AC V5XG59.1 #=GS B2HRH9_MYCMM/29-192 AC B2HRH9.1 #=GS F5YVW3_MYCSD/34-197 AC F5YVW3.1 #=GS H6RDG1_NOCCG/31-189 AC H6RDG1.1 #=GS W5TQE8_9NOCA/37-195 AC W5TQE8.1 #=GS Q5YQH6_NOCFA/31-186 AC Q5YQH6.1 #=GS A9I1F5_BORPD/24-182 AC A9I1F5.1 #=GS C5ACX8_BURGB/35-189 AC C5ACX8.1 #=GS E9SZ99_RHOHA/39-197 AC E9SZ99.1 #=GS Q0C3C3_HYPNA/35-189 AC Q0C3C3.1 #=GS A6WE57_KINRD/39-199 AC A6WE57.1 #=GS K7RSP4_ACIA4/65-225 AC K7RSP4.1 #=GS Q6A5G0_CUTAK/68-227 AC Q6A5G0.1 #=GS YQCF_BACSU/32-189 AC P45941.1 #=GS F2F0G7_SOLSS/32-188 AC F2F0G7.1 #=GS U5MXY2_CLOSA/32-189 AC U5MXY2.1 #=GS R5KLR7_9CLOT/30-185 AC R5KLR7.1 #=GS Q8XQT6_RALSO/33-189 AC Q8XQT6.1 #=GS A9WIB3_CHLAA/34-188 AC A9WIB3.1 #=GS F4CF63_SPHS2/41-201 AC F4CF63.1 #=GS S5ZMN3_9SPIO/33-192 AC S5ZMN3.1 #=GS F9YVZ2_CAPCC/36-192 AC F9YVZ2.1 #=GS Q5F702_NEIG1/22-176 AC Q5F702.1 #=GS H8GNL2_METAL/23-182 AC H8GNL2.1 #=GS B2JXD5_PARP8/27-181 AC B2JXD5.1 #=GS B1YF84_EXIS2/24-186 AC B1YF84.1 #=GS A5UTZ8_ROSS1/60-223 AC A5UTZ8.1 #=GS F2JNJ9_CELLD/464-635 AC F2JNJ9.1 #=GS Y111_UREPA/40-196 AC Q9PR33.1 #=GS D4K3C3_9FIRM/171-343 AC D4K3C3.1 #=GS R6BN28_9CLOT/868-1039 AC R6BN28.1 #=GS R7AK85_9CLOT/365-536 AC R7AK85.1 #=GS R6S0K5_9CLOT/832-1002 AC R6S0K5.1 #=GS D1AMA5_SEBTE/39-208 AC D1AMA5.1 #=GS R6QY29_9CLOT/194-356 AC R6QY29.1 #=GS R9TAC9_METII/161-329 AC R9TAC9.1 #=GS R6CRU3_9FIRM/173-347 AC R6CRU3.1 #=GS R7CX89_9BACE/155-325 AC R7CX89.1 #=GS F9YUZ4_CAPCC/379-553 AC F9YUZ4.1 #=GS G8LYF9_CLOCD/37-211 AC G8LYF9.1 Q97IJ6_CLOAB/222-390 ....VNLNIM......RNT..EN.DKFITIVTTGMSDCPMD........DSDEAFE......ERFAELIIKLP.KDWLID....KNNIKD.........VNNYWPLGWIRRIAHIPHL.......Y.DGW....IGKDII.I.PNGEPPQP.........FAP.NTKLSCIMICQP..........DEKEL.....H.RF.TTSKGNI....................................INL.YTLIPIYKEERNMALIK.....GCKYLRKR....MED......RGIDEILNITRE D2R4H9_PIRSD/235-402 ....VRVHVI......PAG..EE.SPFLTIFTTGMSARPMT........VPEGSEA......FEYAELLMHLP.GDWKWK....ESLQED.........SPYSWPFQWLRNIAYLPHL.......N.ATW....LGGPHTII.ASDDPPVP.........LGA.GTDFTCLLLVAD................LIDCA.PI.ELPSGRS....................................VRV.YTVVPIFTDERDLELRE.....GVVALLKK....FQK......YFIPSVCLPGR. 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A0A384K9H2_YERPE/199-363 KWPPMAISQH......EKE......GIYYFLTIGVSIRPQP........WVEILFND.DASQYRRMEMALAID.GQYVNE...................DNAIHMASALAGFAHVPWN.......K.ITW....LGEGHT.L.ESA..VAP..............QGYEGYILSS........ALYADADH.....L.TL.PHQQDDP....................................VNI.YWASPIFTRERELAHSVP...NGGSDLLKK....LQQ......QGVNHIFSPR.. D8MQ03_ERWBE/197-361 NWPPMAISQH......YHQ......GSWYFLTLGMSIRPMP........WVDFLFED.LAGQHRRVELAMAID.AEVMTE...................ENAVQMASALASFAHFPWA.......R.LSW....LGEGHT.L.ESS..VAP..............VGFEGFLISG........ELSGEAGQ.....F.KL.PKRDGEK....................................VNL.LWTTPVTTAERELAEAEE...SGGNQLVER....LRQ......EGCNHVFRPR.. Q8EYV4_LEPIN/197-371 KYPQLGIARF.........QSEKYPEILIYSTIGMSAQNMP........TVELFHK..DYENFSRIELIFAVK..............IGSEGLE.....RSESWVPHLIGELIRFPWN........MAKW....FGNGHT.ITMSRKDPEA............LYLNFTSILFRDLT......SFSNTPDL.....T.GL.ISENGKR....................................VRF.LTLLPLSEEEKEYAQKD.....GIQSFERI....WNE......KGFPWYHDSERQ B0SQ97_LEPBP/196-376 KYPSLGIASF.........LPKEFPGIKIFSTVGMSVQNQP........SIELYHK..DYENFSRIELVFAIQ..............LLKDAPD.....KSETWIQHVLGEMVKFPWN........TGIW....FGHSHT.IQNPRKDPDQ............LYLDFNWFVLRNVTEELDQGSTEVLPKL.....N.GL.ITENGKR....................................ANF.LFLTPISTEERICFMRE.....GSQKFWET....WKK......ETYGFFHDSERR Q1DFH8_MYXXD/63-224 NWGPMGVRVS.........PPSESYPYWTYVTSGLSNPFT.........VAPGEDIPDGAPSGLGYEMVIHSP..........................EEAKWPVFRLLDMMAYNLV.......SLRA.....FAMGHR..............YPVEGSLDGGESKLSGFVFVRD........PSRPDHF..........VLPSGK.....................................VQL.LTLVGATRNEMAFARSN.....GMDKLMAK....LVA......AGSGYITQPDRE Q4KDX4_PSEF5/53-218 RWLTHGVFES.........PPNTRRSSWLYVTSGLSNAWED............ARPDADGESGMGHELLLETR..........................EQSPWALRLLRNFCAYQLL................LAAGRF...GEQPPLGEWDRMRTGEPINGGDSLLQALLFIPA........PGFAGPR..........QLLSGR.....................................FGF.LQIIGLTLAEHAWGQAE.....GYPALMER....LAL......AGAAPVLDPTRA Q8CMI1_SHEON/46-204 RWLTHGVFKS.........PPNGNRSTWAYITSGMSNPWET..............NEPEEHSGLGVEFIIETE..........................KEETWAVEVLQMLMAYNLL................LAAGQM...GDFPLLGDGDRVPLAL.....SDAIRTMMFTQP........VSFPHCF..........SLKSGR.....................................VDL.LQVVGITPAELQVAKQT.....SSDKIRTQ....LIS......KLGSLVTSKERE R7GC25_9CLOT/42-205 GNDPLDGISIYDGG...........NYWHFVTYGLSELYEK........ETDDTEY.....SGYGMEFTFKLKK..................DNDEDEEQEIKCICGILQTIARSTFN........KGEI....FNPFEY.LYTGQTVGID..........AKQKSNITGFITVP............DDKF.....Q.TL.NTPNGK.....................................VEF.VEFVGVTNKEIEAVKNK...ELKVKELYEK....LGS..........GITDYNRQ Q8DWK9_STRMU/68-232 GPDPLDGISVYDAG...........DFWHFVSYGLSELYTK........ESTDSEY.....SGYGIELTFKLKK....................STNDEEEIKNGCGLLQYVARYIFK........TGKV....VLPEEY.IYMKQTVGID..........IQQKSKLTGFLTVS............DNLA.....K.PL.DTPHGK.....................................VEF.VTLIGATDAELRSVYESETSKLEVRKLLQE....LGN..........QITDYNRQ I3ZXL0_ORNRL/52-226 ..DALQGVSIFDCD.......EPE.NHKHLISYGLSELYFN........EKAFGQKF....SKWGFELTFRLKP..........FELDADKKNE...KFGDPTWAVQVMNNLAMFVNE........TQHW....FMPHQF.L.PING.PIR.........LEC.DTDITGIIFVE............DSVL.....G.KI.DTLHGE.....................................VQF.LQMVGITTPELEFLLEN.PNLDSIMSLEEK....LKK......DNPLLITDLNRK H8KXR3_SOLCM/47-216 GNDPIDGSSIYDSD.......NQE.FHRHIISYGMSELYYD........EEKVGEQF....SKWGFEFTFRIKP..........FE......ED...K.TDPLWAIEVMNNLARYVYE........SGRW....FEENHF.V.PANG.PIR.........LDT.DTDIVGLVFTL............DPEL.....G.KL.NTPHGE.....................................VSF.LQMVGITSKELERLRAN.PTTEEVANLIEE....MKI......NNPLLITDLNRR C7PA06_CHIPD/47-216 GEDPIDGTSIYDSE.......KQM.KHLHLVSYGMSQLYYD........EEQAGKEF....SKWGFEFTFRLKP..........FA......ED...E.GDPGWAIRMMNNLARYVYK........SERW....FEPYHF.V.PANG.PIR.........LET.ATDIVGLAFVQ............DPEL.....G.VI.NTPHGE.....................................VTF.LQMVGLTKKEVERLLAK.PQTSEVEKLIDE....MRE......YNPLLITDLDRA H1Z7P6_MYROD/47-214 GENPLDGLSVYRSS.......QQE.DHFHLVSYGFSNLYYD........EEKIDAEY....SGFGFELTFRFK...................QQ...GDDNIHWAMNLMQNLAKYVFD........SGKW....FEEFHF.I.PTNS.PIR.........LEY.DTDLVGIAFVQ............DPEL.....G.FI.DTPHGR.....................................VDF.LQMVGITQKELDLLWEN.PKLSETAKLITN....LRQ......NNPLLITDLDRK D5ST45_PLAL2/47-215 GPDPLDGISAYPCE.......DGGIDHLHFVTFGYSSLYYD........EESVGGDF....SKFGFEMTFRLAS..........SL......PP...R.EEPIWVCNLLQNLARYVFE........SGKW....FDNYHW.I.PANG.PIR.........ADH.ETDIVGLAFVH............DTKL.....Q.AA.ETPHGH.....................................VDF.IQAFGITQSELDSLMNK.STT..CEEIIEL....HRK......SNPLLVTDLARK H1YBR1_9SPHI/87-250 ...PLWAVECYNST.......RQD.AHFHFMTIGFSNLFYD........EDAIDDEY....SGFGFEITFRHLPF.................ND...DPEKPIWAVNFLQNIAKYVFE........SGKG....FDDFHF.M.SANG.PIR.........SET.ETDITAFTFVT............DAEM.....G.EI.NTPHGK.....................................VKF.LQLFGITSQEYIDIKNK...IYTAKELTER....QKT......NNPLLITDLTR. 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F0RD43_CELLC/48-212 .TEPIDGISVYNSN.......LQE.PHLHYISYGFSELYYN........EESVGEEY....SKLGFELTFRLKK..........YS......DE...D..NVNWACNLIQNLGKYVFS........KEKW....FEEYHL.I.PANG.PIR.........SNY.NTDITALAFVI............DKEL.....G.IL.NTPHGE.....................................VQF.LQMVGLTNTEYEELKQN.PSTTKTKEL.......LKQ......NNPLLITDLERK D9SU31_CLOC7/51-215 GNEYLDGYSIYKSP.......K...GYRHIVTYGLTELYAD........EKAFGGEY....SKWGYEMTVKLL...................AK...DTEECMWAISMLSNLARYTFT........SQKY....FQPYQY.I.AGNGEPIK.........IGS.NSKITALVVVN............DTEL.....T.TI.DTVHGK.....................................VGF.MQLVGITERELEIIKED.R..AQVFELIEL....MKE......DNPMLVIDLSRT R5AT21_9FIRM/51-215 GDEYLDGFAVYDTG.......K...GYQHIVTYGMSELYPS........MAAFGAEY....SKWGYEMTMKVR...................ES...YAETGTWALDLLAQLARYTYQ........TGNF....FEPGAY.I.PGDGSSLH.........PEL.NSAITGLAIVS............DTTV.....A.PI.ETVHGK.....................................VAF.LQLVGLTQPELDALARD.P..DALDSILER....MRA......DDPELVLDMRRT R7H1N5_9FIRM/51-213 GDEFLDGYSIYPSG.......R...GYQHIVTYGMSVLYAD........AEAFGEPY....NGWGYEMTMKLQ...................ED...RVEDCLWALDLLSILARYTYQ........SERY....CKVGDC.I.PGNGTALR.........KG...SAITAWVIVS............DSSA.....Q.TQ.DTVHGK.....................................LEF.LQLVGITAQEAAAIQAD.Y..HNLNVLLDR....MRA......DNPELVTDMHRT J7L1X9_NOCAA/84-246 STEGLNGVLAYPLE...........GHWLLVTFGLTELGEK........TSEEKRV.....SGAGFEFTCRIPR..............EDG.DE.....TVPAWILRVLHALASQ.FL........AGTA....LDVGHW.I.VTPA.PLG.........GEPANGDMTSLAIVP............DVDI.....R.VM.DTDNGL.....................................VLF.FQVVGLKTEEGEYAQKA....DTVAPIVAL....LRD......RDPKMITDPNRE D7B9H8_NOCDD/35-197 SDKGLDGVLAYPLD...........GHWLLVSFGLTELGEK........TSEEPRV.....SGSGFEFTCRVPR..............EDG.DE.....AVPAWILRVMHALADR.FV........AGSD....LDVGHW.I.VTPS.PLG.........GEPANGDMTSLVIVP............DTEI.....R.AM.DTPNGI.....................................VLF.FQLVGLLAEEGEAMQQA....GTAAPLVAL....LRD......RDPRMVTDPSRE C0ZD96_BREBN/72-236 GNDPLDGISAYISD.......EPN.PHWHFVTYGFTELYEK........ESENEEE.....SGFGFELTFRLAR..........KD......DE...E.EPPAWALNLLQNMGRYVFN........TGNV....FQAGDH.L.DANG.PIC.........LGA.DTQLTALAFVT............DPQL.....A.EM.DTPNGR.....................................VQF.LQMVGITGDELDAMMA.....WNTRGVLQS....GLP......YMPFYITDLERD D3EDK5_GEOS4/39-203 GPDPLNGISAYVSN.......TPM.PHWHMVTYGFSELYDK........ESDHLEE.....SGYGFELTFRLAK..........PK......DE...E.EPPAWALNLLQNMGRYVFN........SGNI....FRSGDY.L.DANG.PIC.........LGA.DTQLTALAFIE............DPEL.....P.AM.DTPNGR.....................................VEF.LQMIGITREELEAMQT.....WNTLGVLQA....CVE......HMPLYITDLNRD R6Q3F1_9FIRM/37-200 GNDPLDGVEIWKSE.......TGV.PHWHYVTYGYSELYEK........ECEDPAV.....SGYGFEMTFRLKC..........GK......EE.....QPPVWPVNLLQNLARYVFS........SGNV....FGVGHY.I.DGNG.PIA.........LET.DTKLTALGFCM............DEEL.....G.EM.DTPNGH.....................................VIF.LQAIGITSDEMEAFMC.....WDGKKFLEE....MSK......YSPFGITDLFRS D0IVN9_COMT2/51-220 GEEPLDGVSVYRSE.......QGV.PHWHYVSYGFSDLYGD........LDDSYDIAPGKPSGYGFELSFRLMR..........AA......SE...Q.EPPSWPVNFLQNIARYVFR........TGNV....LAPGHW.M.TASG.PIK.........ADA.DTLLTEMGFVQ............DPEL.....P.AI.HTPYGD.....................................LMF.LQLVGLTSDELREVRR.....WNVLGALQS....LQS......YMPLWITDLARP H9JRL8_BOMMO/87-271 GQDPLDYISMYRNPGKPE...ENIPPHWHYISFGLSDLHGDGRVHPPP.DRAALSAGAPLPSGCGIELTFRLA...................ADG..AEHPPLWPAALLQALARYVFT........TGNK....LCAGDH.I.SWHR.PLD.........GERSGGRMRHLLVAT............EPQL.....R.HA.RTPHGI.....................................VTF.LQMVGCTSRELRAAQR.....SSVCEVLKL....IAQDPRC..GGCWLVTRMER. Q17FL2_AEDAE/52-234 GQDPLDYISMYHNAGDPD...KNIPPHWHYISFGLSDLHGDGRVHLP.....DTIGGLEPRSGMGFELTFRLIK..................PANCTDEKPPTWPANLLQALAKYVFQ........SGNR....LCFGDN.I.PWRR.SLD.........GK..ASSIQHMLIAE............DPQM.....S.RT.ETPFGW.....................................VDF.LQIVGVTNEELEQASR.....WNGKGILNL....LQKDPTT..GGDWLITDMARS B4M095_DROVI/49-241 GSDPLDYISMYSNRGQGEGESERIPPHWHYVSFGLSDLHGDQRVHLK..EEHTT......RSGMGFELTFRLAKTDAELRQQQEC.......PEK..SIRPPTWPANLLQSIARYCFQ........TGNG....LCFGDN.I.PWRK.GLD.........GS.ANSRMQSLLVAQ............DPQL.....G.SI.DTPFGT.....................................VDF.CQIVGVTEEELEQASR.....WNGRGVLNF....LSKDVQT..GGDWLVTNMQRT B4NI11_DROWI/52-243 GQDPLDYISMYNNNGDPE...KNVPPHWHYISFGLSDLHGDERVHMRSTEEQST......RSGMGFELTFRLAKTKAEIQQQVQC.......PEK..SLRPPTWPANLLQSIGRYCFQ........TGNG....LCFGDN.I.PWRK.SLD.........GSPANSPLQSLLVAQ............DPQL.....G.CI.ETPFGT.....................................VDF.CQIVGVFEDELEQASR.....WNGRGVLNF....LRRDVQT..GGEWLVTNMQR. B3M1W5_DROAN/50-239 GQDPLDYISMYNHPGDMD...RNIPPHWHYISFGLSDLHGDERVHLR..EEQAT......RSGMGFELTFRLAKTRAELHQQLEN.......PEK..PQRPPTWPANLLQSIGRYCFQ........TGNG....LCFGDN.I.PWRR.SLD.........GR.DGSKLQSLLVAQ............DPQL.....G.CI.ETPFGT.....................................VDF.CQIVGVFENELEQASR.....WNGRGVLNF....LRQDVET..GGDWLVTNMDRT B4QS75_DROSI/48-237 GQDPLDYISMYNYPGDVD...RNVPPHWHYISFGLSDLHGDERVHLR..EEGVT......RSGMGFELTFRLAKTEVELKQQIEN.......PEK..PQRPPTWPANLLQAIGRYCFQ........TGNG....LCFGDN.I.PWRK.TLD.........GS.TTSKLQSLLVAQ............DPQL.....G.CI.DTPTGT.....................................VDF.CQIVGVFDDELEQASR.....WNGRGVLNF....LRQDMQT..GGDWLVTNMDRQ H2YPK1_CIOSA/34-210 GPDPLDYVSMYYNKGDPE...HSIPEHWHYITFGFSDLHGDSRVH....P...T.SNSDGPSGFGFELTMRLK...................REPS.ESGPPTWPAELLQALARYVFQ........SENA....LYSGDH.V.SWHA.PLD...........NCESRLQHMLMTD............DPQL.....P.TV.TTSIGS.....................................VNF.IQVVGVCTEELQAAQQ.....WNGPGVIEL....LKTIPLS..GGPWLVTDMRR. K1Q903_CRAGI/57-237 GPDPLDYISMYANPGDEN...RGIPPHWHYISYGLSDLHGDGRVH....DHNFRCNTNEGPSGFGFELTFRLK...................RESG.ETNPPTWPATLMQALARYVFQ........TENI....LYSGDH.V.PWHM.PLD...........GSESRIQHMLMAE............DAQL.....L.PI.TTPFGV.....................................VNF.VQIIGVCEEELRAAQH.....WNGPGVIEL....IRSQGCA..GGPWLITDMRR. G3NWC3_GASAC/53-229 GPDPLDYISMYRSAGCAA...QDIQEHWHYVSFGLSDLYGDNRVH....E...F.TGADGPSGFGFELTFRLK...................RETG.ETAPPTWPAELMQGLARYVFQ........SENT....FCSGDH.I.SWHS.PLD...........NSESRIQHMLLTE............DPQM.....Q.PV.QTPFGS.....................................VSF.LQIVGVCTEELQAAQQ.....WNGQGILEL....MRGVRVA..GGSWLITDMRR. W4XDB0_STRPU/52-229 GPDPLDFISMYSNPGEPG...HGIPPHWHYVSFGLSDLFGDGRVH....E...IPTGPNGPSGFGFELTFRLK...................KEPT.ETAPPTWPAELMQGLARYVFQ........SGNT....LCNGDH.V.SWHS.PLD...........NSESRIQHMLMAD............DSQL.....P.TI.TTPHGT.....................................VSF.VQIVGVCSEELQASQR.....WNGLGMLDL....LKSMEVA..GGSWLVTDMRR. W4XXP5_STRPU/31-205 GPDPLDFISMYSNPGEPG...HGIPPHWHYVSFGLSDLFGDGRVH....E...IPTGPNGPSGFGFELTFRLK...................KEPT.ETAPPTWPAELMQGLARYVFQ........SDSVCQAILCS..Y.M.PKPL.QLS...........AFHNNDEYWLLMNFFKILA......DFHL.....P...................................................MQIVGVCSEELQASQR.....WNGLGMLDL....LKSMEVA..GGSWLVTDMRR. A0A1X7VXQ0_AMPQE/45-216 ......FINIYINPGDKK...KGIPPHWHYVTCGLSDLYGDSRVH....E...V.AGPDQASGFGFELTFRLD...................CDTSMPSSPSTWPAELLQALSRYVFQ........SDNV....LCVGDH.I.SWHT.SLD...........NSDSRIQHMLLAS............DPQL.....K.PF.SSSLGS.....................................VSF.IQIVGITSEELQAAQQ.....WSVPGVLDL....MRQKPLS..GGEWLITNMRR. A7SLZ8_NEMVE/42-229 GPDPLDFISMFGNAGSPM...EGIPPHWHYVSSGLSDLHGDGRVH....D...F.TGRDSRSGYGFELTFRLK...................KQPG.ESAPPTWPAELLQQLARYVFQ........TENI....LCAVDH.V.SWHA.PLDYTPSTMGHYPSSKMSQIQHMLLAE............DPQV.....P.TI.HTPLGR.....................................VEF.VQILGVTAEELQAAQH.....WNCKSVLDL....MRKTPPA..GGPWLVTDMDR. E0VUP1_PEDHC/53-229 GPDPLDYISMYLNPGNPS...INVPPHWHYISFGLSDLHGDGRVH....E...V.SDSDSPSGFGFELTFRLK...................REPE.ETAPPTWPAAVMQALAKYVFS........SGNT....LCPNDH.V.SWHC.ALD...........NSESRIQHMLMYQ............DLQL.....G.TV.QTPFGP.....................................VNF.VQIVGITKEELQAAQH.....WNGAGVLDI....LKRLPGA..GGEWLVTDMRR. E9FSV5_DAPPU/76-255 GPDPLDYISMYDHPGIPE...LHIPPHWHYISFGLTDLHGDGRVH....E....PSGPEFPSGFGFELTFRLA...................KKSG.EATPPTWPAALLQALAKYVFH........TGNS....FFAGDH.V.SWHC.PLD.........GSDFECRLQHMLLAE............DLLL.....P.PV.QGPLGS.....................................VKF.LQVVAVTEEELQVSQH.....WNGTSVLEL....LRRVPSA..GGPWLVADMQRQ T1I0U2_RHOPR/44-222 GPDPLDYISMYSNPGNQQ...LGIPPHWHYISFGLSDLHGDGRVH....E...R.SSPAELSGYGFELTFRLK...................RDVG.ETAPPTWPAALLQSLAKYVFH........SGNT....VCAGDH.V.SWHS.ALD...........GSESLIEHMLLDI............DPQL.....G.SI.NTPCGT.....................................VDF.VQIIGVSYEEMRAAQR.....WNGMGVLDL....LKRIPNGGCGGLWLVTDMRR. K7J9A3_NASVI/77-263 GPDPLDYISMYENPGNPE...LGVPPHWHYVSFGLSDLHGDSRLH........PRTGPGQLSGFGFELTFRLL...................RERG.EKTPPTWPANVMQQLAKYVFT........SNNM....LMPGDF.V.SWHS.PLD..NSSNGGPGGNRPSRINQILMGQ............DPQF.....P.EIAHTPHGD.....................................VSF.VQIVGVTSEELQAAQH.....WNGLGVVNL....LKAARGC...GPWLLTDMRRT F4WTN0_ACREC/63-239 GPDPLDYISMYANSGYPD...LGVPPHWHYISLGLSDLHGDGRLH........PKPGSGRASGFGFELTFRLA...................RERG.ETTPPTWPANVMQQLAKYVFN........SGNT....LMPGDH.V.SWHA.PLD...........GGNGCITQILMGQ............DPQL.....PTSI.STPHGD.....................................VSF.VQIVGVTSEELQAAQH.....WNGLGVVNL....LRSARGC...GPWLVTDMRR. E2BJT6_HARSA/79-255 GPDPLDYISMYASPGCPE...LGVPPHWHYISFGLSDLHGDGRLH........PKNGPGRPSGFGFEFTFRLA...................RERG.ETTPPTWPANMLQLLAKYVFS........SGNT....VMPGDH.V.SWHA.PLN...........GESGRITQILMGR............DPQL.....PVSI.STPHGE.....................................VSF.VQIVGVTSEELQAAQH.....WNGLGVVNL....LKSAPEC...GPWLITDMRR. K0F935_9NOCA/36-201 GPDPLDGISAYSRT.......EPV.PHWHYISYGMTELYEK........EWDNPAE.....SGWGFELTFRLMR..........AA......AD...T.EPPAWPANFLQNLARYVFQ........SGKW....FEPGHT.I.KANG.PIA.........ADQPDSGIHAVGFTA............DPEL.....G.TI.ETPHGS.....................................MRF.LQIVGLTMPEYRAAQG.....GNTRAVLDQ....LAP......HLPLFVTDTGRG D8J272_HERSS/81-245 GPDPLDGISVYYRS.......HPV.PHWHYVTYGFSELYDK........EQEDQEE.....SGYGFELTFRLQA..........AP......GS...T.EPPSWVFSLLQNLARYVFS........TGNV....FRPGQW.M.SANG.PIA.........LDT.DTRICSMAMTS............DPEL.....P.AL.DTPNGH.....................................LRF.IQVVGLTLEEEHAAKQ.....WSPQDLLDA....LLP......HMPLWITDLDRG D1ANL7_SEBTE/66-229 GEKKLKGISVYDVK.......GKN.PHWHFVTYGLSELYEK........ESANPEK.....SGYGIELTFRLAK..........EE......SE...T.EVPNWAINFLNNLANYIFK........TGNV....FNEGHY.L.NTNG.PIA.........ANS.NTNLKAVVFFR............DAEL.....N.KVYKSPNGS.....................................LKF.LQITGITHDELEAVIA.....WNTEKVTEL....L........GLPLNITYLNRD Q0AP68_MARMM/35-202 THQPFQIVEVAYPDPVADR.........AFATLGLSNLRVC...............ASNPNQMIGTELIIGLS...................QK.....HAGSWVLQMLERLAKSVIG...GEDPVGPGWGSNPVGPGWVSM..............................IFDPLPTAPWFDRFYLSEL.....K.TI.SPSTGDEITRIND..............................VSI.LSVVPISESEHEFIAQS.....GSIEFDRA....LA.......NLRAHPWDLDRA A4F753_SACEN/29-181 RERGYHLVYC.......DH..RD.GAHVSVLTSGLRMHTAG........APLPQ............ELVCTTR.AD........QERHAR.................HLTGVIAELLT.......ESRSR....VGYGAL.I....MNDRA.........LLPDTEIAGALAAPHP...HL......GDEF.....D.VL.LHEGRPV....................................LQI.ITLVPITRNEAQLVARY.....GSDVLY.D....RWE......EQGADLLDVHRP Q9FBK0_STRCO/29-193 GTDRIEVLRFPAAGQEGD........VVRYATLGMSAQPMA........DPTAVLA..DPVKGPRAELVLSVR.SGA.....ADTDKVLR.................PLAVLAASPQV.......EGVI.....VAPGAS.L....D.........................VGEP....LW....PGAPF.....T.SV.LV.AEPG.GLVEDLELDAP.....................LDPVRF.LPLLPMTPNEAAWKRVH.....GAPALQ.E....RWL......NHGTDLRDPSRR E4NGL4_KITSK/51-210 GADRIEVLRF...GPDAD.......GLVRYATLGMAAAPMA........DPATPVA..DPVRGPRAELVLTVR.GG........RDEVHR.................ALAVFAASPQV.......EGLV.....VAPGGS.L....D.........................LGSP....LW....AGAPF.....T.SV.LA.AEPG.GLVEDLDLPAP.....................ADPVRF.LPLLPMTPNEAAFKRVQ.....GAEALQ.E....RWL......RHGTDLRDPARR E3ITQ4_FRAIE/28-207 GADPIDVLRF...GPQPD.......GFFRYATVGMSAEPMS........DPTVAVR..DPA.GPRAELVLSLR.TP........RDSVVR.................RLAVLAAIPAI.......EGVP.....VVAGSG.L....D.........................LGEP....LW....DDARF.....H.AV.LV.GEPG.GLIPDLPTTDPTDPAESGSLASPDGPGASAGEPAPVRF.LPLFPMTANESAFKRVH.....GAGALR.E....RWL......ADELDLRDPTRR A8L2G2_FRASN/38-204 GTDPIEILRF...GPDPD.......GVVRYVTLGMAREPMT........PPEATVR..DPA.GPRAELVLSLR.GH........REGTAR.................VLAVLAAVPVV.......EGRP.....MIAGAG.L....D.........................LGEP....LW....DGARF.....T.AV.LI.GEPG.GLVPDLELAAGDAARAASA.............PAPVRF.LPLFPMTPNEAAYKRVH.....GATAMR.Q....RWL......DAGTDLRDPDRA Q0RCX5_FRAAA/31-197 GTEQLDVLRF...GPDRG.......GVVRYLTLGMSREPMT........ASDSAVR..DPA.GPRAELVLSLR.GH........RDSVLR.................RLAVLAAVPAV.......EGRP.....VAPGAG.L....D.........................LGEP....LW....DGAPF.....T.AV.LV.GEPG.GLIPDLPIADALDDPAFAA.............AAPVRF.LPVLPMTTNEAAFKRVH.....GPEALH.Q....RWL......AAGTDLRDPNRR V9XMU9_9NOCA/34-192 GLEPIEVLRF..RGA..E........LLRYATLGCSRHPMG........DPTDMVA..DPTRGPRAELVLSLR.DNE....GV.TAGVHR.................TLAVLAALPAV.......EGVV.....LTDDAL.L....D.........................LGEP....LW....PGAPF.....T.AV.LL.ETAD...VPSLELPEP.....................SDPVHF.FEARPITGTEAAWKRLK.....GTEALR.E....AWE......EAGIDLSDPRRA F1TJG7_RHOHA/31-190 GLEPVDVLRY..PGTGDA........PVRYVSLGCSRHPMG........DPSDMIA..DPTRGPRAELVLSLL.GGA....GV.ASGVHR.................TLAVLAAAPAV.......EGVV.....LRPDGL.I....D.........................LGEP....LW....KGVPF.....T.AV.LL.GESD...IPDLELPEP.....................LDPVQF.LEVVPLTGTEAAWVRLK.....GAAALR.E....AWT......EAGIDVRDPGR. D5UW29_TSUPD/33-194 GLEPMTVLRW..IGSGAR........TVAFASLGCSRHPMT........DPNAIVAVED...GPRAEVILELR.PAADGPGAA.LDGVHR.................SVAILAASPAV.......EGLV.....LAPDAL.V....D.........................LGTP....LW....AGAPF.....T.AV.LL.GESA...VPD..LERD.....................GEPVRF.LRADPITANEAAWVRLK.....GAAALR.E....AWA......EAGIDPADPGRP F6EPB7_HOYSD/32-189 GVEPIEVLRF...GPAPS.......GLVYYATCGCSQQPMG........DPADLMA..DPVRGPRAEVVMRLR.GG........ADQVLR.................PLAVIAASPGV.......EGLI.....LAEDSL.I....D.........................LGEP....LW....PGSAF.....T.AV.VL.GRSE...VQPLTLSEP.....................MSPIEF.FDAVPITPTEAAWLRLR.....GVSALR.E....AWA......EASIDTTDPARS A0A1N3K152_9MYCO/35-196 GSEPYELLRY...GPDDA.......GLTHFASVGASRYPMA........DPGEMIA..SEHLGPRAEVLISLH........GNVFPGLAR.................SLAVLAASPAV.......EGLV.....LTEDAL.I....D.........................LGQP....LW.DDPDRQAF.....T.AV.LL.QASD...VADLSLPEP.....................LSPVRF.LAAVPITANEAAWVRLK.....GAEALQ.D....AWR......QADIDVTDPSRA A1TDK8_MYCVP/34-192 GADRIDVMRF..AGPGDV........AVHYVSLGCSRYPMV........DPTEMVA..DPVQGPRAEVVVALR........GPSPAGLSR.................SVAVVAAAPAV.......EGLV.....LAPDAL.V....D.........................LEMP....LW....EGAPF.....T.AF.LL.GRSD...IEDVVLPDP.....................LSPVVV.LSAVPITATEAAWVRLK.....GAEAMR.E....AWV......QDGVDPTDPRRR A0R2B9_MYCS2/34-196 GTERIDVLRY...GPDPR...TEGADVYHYVTLGCSRHPMF........DPTELVS..DPIHGPRAEVMLSLR........GPTPTGLAR.................SLAVVAAAPAV.......EGLI.....LDADAL.I....D.........................LENP....VF....ETAPF.....T.AY.LL.GLSD...IGEVTLPDP.....................LSPVKL.LTATPITATEAAWVRLK.....GADAMR.E....AWQ......TDGVDVLDPARR V5XG59_MYCNE/34-192 GADRIDILRF...GPDGA.......GVNHYVSLGCSRYPMA........DPTDLVA..DGVRGPRAEVMVSLR........PPSPVGLAK.................SIAILAAAPAV.......EGLV.....LEPDAL.I....D.........................LSGP....LF....EAAPF.....T.AF.LL.SAGP...VADIELGEP.....................LSAVTV.LQATPITPTEAAWVRLK.....GAEAMR.E....AWR......TDGVDVFDPHRR B2HRH9_MYCMM/29-192 GADPIEVLRF...RSAAS.......GLVHYVSLGCSRHPMN........DPTQLVA..DPHRGPRAEVVLSLR..NP....EP.TSGLAR.................SIAILAATPAV.......DGVV.....LVADAL.I....D.........................LGTP....LWARPSERVAF.....T.AV.LL.GRSD...IPDLPQQQP.....................RDPVQF.LCATPITATEAAWVRLK.....GAEAMR.Q....AWR......NDGVDVLDPHRK F5YVW3_MYCSD/34-197 GVEPIEVLRF...GPGPD.......RMVHYVSVGCSRHPMG........DPGQVLA..DPVHGPRAEVVLRLR..IS....GS.DAGLAR.................SLAMVAAAPVV.......EGVV.....LAADAL.M....D.........................LGGP....LWTRQSGGVPF.....T.AM.LL.GDSD...IAELALAAP.....................REPVRF.LSAIPITATEAAWVRLK.....GADAMR.D....AWR......ADGVDVLDPDRP H6RDG1_NOCCG/31-189 GLEPIEILRI...VPGDD........LVHYATLGGSRHPMG........DPSEVLA..DPVKGPRAELILTLH.AGL....GA.ASGLAR.................TLGVLAAAPAV.......EGVV.....LQEDAL.L....D.........................LGEP....MW....TNAPF.....T.AV.LL.GPSD...IPDVPLPEP.....................AEPVRY.LDVVPVTATEAAWVRVR.....GAQALR.D....AWT......EAGIDVRDPNR. W5TQE8_9NOCA/37-195 GLEPIEILRI....PDGE........FVHYVTLGGARHPMT........DPAAALA..DPVRGPRAELVLTLR.GGA....GA.QAGLPR.................GLGVLIAAPAV.......EGIV.....LQPDAL.L....D.........................LGEP....VW....HNAPF.....T.AA.LL.GDAD...IAEVPLPEP.....................ADPVRF.LSIAPITATEAAWVRIR.....GAAALR.E....AWA......EAGIDVRDPDRA Q5YQH6_NOCFA/31-186 GLEPIDILRI....PDGD........LVHYVTLGGARHPMG........DPADLVA..DPVRGPRAELVLTLR...A....SA.LPGLPK.................SLGVLVASPAV.......EGVV.....LQPDAL.L....D.........................LGEP....MW....QGSVF.....T.AA.LL.GESA...VPDVVLPEP.....................ADPVRC.LAVTPVTATEAAWVRVR.....GAQALR.D....AWA......EAGIDVRDPNR. A9I1F5_BORPD/24-182 .DLSIDILVV......DDS..PD.DGLVSYSTVGLFETELR........H.GDG....KPLP.MRIELCAEAP.QE........QEFWGN.................ILSTAAFGLMR.......DGHA.....ALPGSA.L....PDCVG.........EYYPDATVPHLYLCVP...FSW....QDGEF.....R.RL.EL.GGQI....................................INW.LQAFPISDAELAYLKTH.....GADAFE.D....LLL......EHDPDLYDLERD C5ACX8_BURGB/35-189 RELA..VLSV......ADA..PD.EDVVSYSTAGLCEFAL............DT....GGFD.TRIELCGAMP.DD........VAHWPD.................ILAAAAFELAA.......AASP.....VRPGVV.V....REVVA.........RCYPKTTVPHLYLSIP...FIW....NDGEF.....P.EC.RL.DGMR....................................INW.LQCFPVSDEEARLASEL.....GADRFE.S....RLD......EAGIDTYDLRRK E9SZ99_RHOHA/39-197 EPAEVSIAVG......DGC..PG.PGYASYATLDMVRFPTN........VTTDD....G..RPIRTELITVGR.AD........YRLLSD.................VLAQCAFQVAS.......GSLH.....VTPNTI.V....PNAVH.........AADPGRSTRHVLLVVP...FIW..............A.TL.EILVDRE.................................EDVTTW.LQAVPITDAELQFASMY.....STDELF.E....RLE......AAGADVSDIDRP Q0C3C3_HYPNA/35-189 ...SVNVLVS......SGA..PE.GTYLSCSTIGLSDR..E........LVLDE....EPMG.FGIELCGALY.GD........ETPFVE.................MLADIAHEVQA.......GEWT.....IGLNTI.L....PDVIQ.........PYFPGTQMQHLLLVHP...FYW.....DEDF.....G.MF.EQ.DGRK....................................TVW.LQIIPISDSEFRLAEEE.....GVEVLE.E....KLE......SSGADVFDLLRA A6WE57_KINRD/39-199 GTRSLDVLTA.........RDAPAAGFTSVSTLTLHRAPNR.................VDGSDVRVELVTVLG.........................GVEPRLATGLLVASAFAAVG.......EAWPLRPGTVFPGVV....................ADLLGGRTEHLLLTAPGTFPRLARYRLEAD...........EFQGGTE....................................VRW.LQAVPLHEGERRFLLDR.....GLDALETR....LAE.......AEVEFHDVGRD K7RSP4_ACIA4/65-225 GDNRVDVLTC......ADA..PA.PGWTTWSTVTLHARPNE........LPMAD....GTKLDVRVELMAVGM.PG........SDVMGK.................ILGSCAFAVLQ.......DGWM.....MAPGVV.Y....GDVVS.........LYDDKATTPHIMWSHP...FTA......GDL.....G.AV.EIDDDLK....................................VHW.LMAVPITEAERTFLEQN.....DYEALA.Q....LLD......SHQVNYTDMHRE Q6A5G0_CUTAK/68-227 EEVRIDVLAF......ADA..PA.PGWSTWSTVSLHAEPNA........VALVD....GTSSDIRAELMVVGA.PG........SDVMGK.................VLGSCAFAVLR.......DHWS.....MAPGIV.F....GDVVS.........MYAPNSTTPHLMWCHP...FTT......PQL.....D.QV.DI.GDMK....................................VHW.LLGVPITEAERQWLEAN.....GFDAFV.E....LLD......AKAVNYTDLQRP YQCF_BACSU/32-189 KNSSIDILSV......SDQ..PQ.EGITSYSTLGLSDHSIN........YEVNG.......TPLRIEIVAAME.SA........SDIYAN.................VLSTCAFNIIN.......SNFT.....CAPGVI.F....KNVIS.........MYDQETDMKHIMFVPP...FLW.....EEDL.....E.LL.EF.SNKN....................................VTW.LMALPISEGELQVAEKH.....GSDYLQ.D....LLE......SKQIDIFDIKRE F2F0G7_SOLSS/32-188 NVSNIDILST......VNR..PF.DGVSSYSTIGLSDHSIE........LTVEK.......TPLRIEIVGALA.TD........YKQYPN.................ILASCAFCIIN.......SKFS.....VSHGSV.F....RDIIK.........TYYPNTEMKHILFVSP...FLW......EDL.....N.TL.EF.PNKK....................................VAW.LLAVPISENEYLFAQEK.....GTDTLE.E....LFE......QEEIDIFDLERE U5MXY2_CLOSA/32-189 KENSIDILSC......SDR..PY.NGITSYSTIGLSSYSIG........YKADT.......VPLRVEIVGACA.SG........VDCFRN.................IVASCAFNIMN.......TKFK.....CYPGVI.F....ENVVK.........FYMPDCFMKHILFISP...FLW.....DDRL.....K.TL.SF.EDKK....................................VAW.LLAIPISEEEFKYAKDK.....GSDALE.E....LFE......EKQIDIFNLNRK R5KLR7_9CLOT/30-185 EVKTIDLMIC......ENC..PD.EGITSYGTIGLFNCNIG........LTYEE.......KPLCMELLAACA.SS........IEDFAN.................IVTTTAFEIMD.......GK.S.....VYPGYI.F....DDVVS.........MYIGNSDMEHILLTYP...FLW.....GDVH.....N.SV..F.DDIT....................................VAY.LMAVPISDKEKEYCLKN.....GLDALE.S....VFE......EKQIDIFDIFRP Q8XQT6_RALSO/33-189 QAISVDLLAA......AGS..PC.SGVMSYGTIGLSDHPVR........INDDG.......DEVCVELLGACA.DA........VKNFPN.................ALTTAAFYTIR.......NQWH.....CVHGGV.L....QNALD.........MYKLSVTMKHFLFTSP...FLW......EEF.....N.GV.DF.GDKK....................................VHW.LLAVPISDAEHAYLRDH.....GLDALE.R....AFE......DRQIDIFDINRD A9WIB3_CHLAA/34-188 KASCIQILTF......DNI...F.SGCRAFCSLGLSLYEEA........IA........N....LAEVILPIS.GGWES........IPF.................VLANTLFYIIK.......NRLI.....LRRGTV.I.GGISNIAP.........EFAQRFGKQAIYFAQP...FGF.....PEGF.....G.EL.VCDS..R.................................PGRVYL...ACLISQSEYLYRKEK.....GTDQFEE.....LLE......ERGVDVFDIERP F4CF63_SPHS2/41-201 RENSLHILNC......IDP..MD.PKSKIYCTIGLSDYPNE........IEMNK....GVLKNIPIELMIAGN.ES........SDKWAN.................ILSTAGFFVTK.......NKWN.....CQPGTV.F....KNMID.........MYHKGTRLKHLLFVEP...VMW.....QEKL.....E.QM.KL.SNKK....................................VHF.LLLIPISDAECKYREKH.....GFDALE.S....IFM......EKEIDITNLNRL S5ZMN3_9SPIO/33-192 ETHSIDILSC......DDP..TD.SEVKFYSTIGLSGYPNP........INIKD....GSVANIPVELLMAGY.KE........YEQIPN.................ILSTASFFIIK.......NKWN.....CQPGTV.F....ETIVS.........DYYR.CDMKHIMFTPP...FLW.....EDKL.....S.RV.EI.DNRK....................................IYP.LLLVPISDKELEYKSKY.....GTDALE.T....LFE......NEAIDIFDIKRK F9YVZ2_CAPCC/36-192 ....IDILSI......DDP..LN.TENSFYSTIGLSDFPNK........IEMND....NSMLNIPVELLMCGY.KK........YDKIGN.................ILATVSFYISK.......NKWT.....CQPGTV.F....ENIVS.........DYYV.SQMQHIMFVRP...FLW.....EDKL.....S.DL.KF.GKKK....................................IHC.LLCIPISEKELRFKEEN.....GLTSLEKM....LFQ......QKNIDIFDIERE Q5F702_NEIG1/22-176 SQYKLNIAAI......PSS..PN.RDLKTYITLGLSKHDL....................NYKSRFEILFVCS....LKYD...ENQIFP.................FLRWLAETIIE.......NKKI.....LLRGQV.V.....YLPR.........SIVNSTKMDALYVSAP...FYF.....DDDF.....Q.VC.YGEH.....................................YNIVF.PLLVPLYKQEAELVEKK.....GWNAFEQF....LLD......NEVGNLSDMNRK H8GNL2_METAL/23-182 SSDGLQVVCF......EDS..PF.KSVDTFFTVGLSHHELR........IS........DEKKVRQELVFPLS.GSDTSTA...ENMV.S.................LLLFICELILK.......DHNA.....LLRGQV.I.....RLPV.........DAAKKLGFDAVYCTIP...VFM.....GDAF.....A.TF.SGSE.....................................PPTVV.VWSIPIYTSEANYVNAN.....GWNKFED.....LLE......EKDPDLFSLERE B2JXD5_PARP8/27-181 ...ALRVVRF......PNQ..PF.QGASTFATLGLSESKVS........LPNGN........HCGQELLFAAW.DRYQ......APHVGS.................FLLTFGAQVRN.......RQRA.....LLRGDV.I....G.PSA.........PLIPGVAANAIYASNP...VIY.....PEEL.....A.RY....DDDG..................................SPTVF.VWLVPLMEAEGRFAKTQ.....GWNQFE.D....ALE......KANPDLLDLDRS B1YF84_EXIS2/24-186 MEENIQFLKF......ENA..PI.NATYTATSLGLIWHSLQ........FE........DGRIAHQEVMMSVK....QPEA...KEDVIE.................LLWRLTTHALE.......TGQA.....FELGEF.Y.....SMPE.........TVFGQYGFAGVYVTAP...IYF.....DESF.....F.IH.HGDDDFD.................................EPEHVLPVWFVPIFESEADYLEQH.....GAEDFDE.....IID......ATEDELLDLTRQ A5UTZ8_ROSS1/60-223 ....FTVLVY...........RANPLYTTLCTLGASYRTIP...........FSRASFGDERGVRYEYIMHAAPSH........EQQVAQ.................LLALIAEYPFI.......HTIE.....IGPGYI.L.PVGEPVVP.............GSSMEYLYFTYP.........................YLDDGRLYESDPWGQIERPDLL.....................IQM.LWVLPIYRSEAQFIRTN.....GMEAFEQR....LQERH....SRIYDAYDMLR. F2JNJ9_CELLD/464-635 TDPPIDILSF......QGE..K....FNALVTNGMRYLPMN........VPEYLKG......NAYAELVMFID.KSFDIS....DEGFLK.........EENSWLLQSLRDLAMYPRL.......T.NSY....LGWGHA.V.GNGEERTP.........YYS.GSDLCGMLIYPP.........VVQEDM.....K.FY.TFKEGEK....................................TTYIYNVMPLYTEEIDFILKH.....SGDAYFDR....IRE......LGISQVIKKNRP Y111_UREPA/40-196 ...EYDILVI......KK......QNLQILMTFGLGAFKSH........NHEENTQ.......ERAEIFLELP.VDWDFN....K..............HENMWPVHFLINIVKYSYS.......N.HLT....LKWLQTFI.NPS..............YFNKSNKIAGFLDLSW..........YGENS.....L.EC.KINNDFF....................................VSF.YQILIIDDEELFYAKTN.....GIRALSK.....FFD......DGKSRIVDLNRK D4K3C3_9FIRM/171-343 .GIHLDICVI......PPR..KD.HNYYTLVTFGMGAHRMN........VPEELTE...KKL.ERAELLINLP.PDWKLS....EKDWQE.........EKWYWPIDVLKWVARLPIR.......DRNTW....LGWGHT.I.SSG...EP.........FAE.STKLCGAMLLNP........GVFGEPS.....S.FC.TLPDGDE....................................VNF.YQLIPLYKEEMEFKLEN.....SVDELIDKCPDEIL...........EVINPTRL R6BN28_9CLOT/868-1039 PDIHVDICMV......PPV..EG.RDYYTLVTMGMGAHRMN........VPKELAE...YKL.ERAELAIALP.PDWKLD....QESMEA.........ERWYWPIRLLKVLARLPIA.......N.DTW....LGWGHT.M.DNQ...SP.........FAE.NTELCASLLTAP........QGIEEDD.....G.VC.ILPNGEE....................................VNF.YQVIPLYREELDYKLEH.....GADALLEKMA.NIS...........FVANPIRQ R7AK85_9CLOT/365-536 PDIHVDVCMI......PPE..GE.RDYVTLVTMGMGARPMN........VPGELAE...YKL.ERAELAIALP.PDWKLD....QESMKD.........EKWYWPVRLLKTLARLPIT.......S.DTW....LGWGHT.V.DNK...KP.........FAE.NTKLCAAVLTEP........KNIEENG.....F.IC.QLPGDRP....................................VNF.YQVIPLYREELEYKIKQ.....SAQELLEIMA.EAG...........FVAEPDRR R6S0K5_9CLOT/832-1002 PDIHVDICVV......PPD..RE.RNYYTLVTMGMGARQMQ........VPEELAE...YRL.ERAELAIALP.PDWRMD....EESMKD.........ERWYWPVRLLKVLARLPIR.......S.DTW....LGWGHT.T.DNQ...RP.........FAE.DTKLCGAILAEP........QNIRKEG.....F.FC.HFPGGEE....................................INF.YQVIPLYREELEYKLEH.....NAEALLEKLA.EAD...........FAVHPDR. D1AMA5_SEBTE/39-208 PDIHVDIAII......PPD..KG.RDFYTLVTMGMGAYKMN........IPDGLKE...YRL.ERAELMVTLP.SDWEIN....NNA............EEWYWPLRWLKILARFPLE.......E.NTW....LGWGHT.I.PNG...EP.........FVE.NTDLSGILLLNP........YSDDERA.....G.SM.ALPNGET....................................VNF.YQMFPVYEEEMEFKRAN.....NAEVLLDLFGDDFS...........HIVDINRE R6QY29_9CLOT/194-356 .DISCDLLLI......PPN..DE.HEFYTLVTCGMGAHKMT........VPS.......DEFYDRAELVLCLP.KSWHVK....SSN............EKWFWPLRLMKSLAHLPIL.......E.NSW....IGWGHT.I.SNG...EP.........YFD.NTELSGVILGNS.........PLMEDN.......VL.ELPNGEK....................................VCF.YQIYLLYEEEMNYKIDT.....SADDLFNLVG.ELN...........PVLDISRK R9TAC9_METII/161-329 PDIHVDIAII......DPD..PD.HNYYTLVTMGMGAHRMT........VPPNFEG...ENF.DRAELVICLP.PDWPIN....SNS............DIWFWPVKWLKVMARLPGE.......Q.NTW....LAWGHT.V.SNN...EP.........FAE.NTKLSGMIVSNM........TDFDEGA.....D.KC.ILPNGEC....................................INF.YQIIPLYREEIEFKVSH.....SKDELIHMLD.GID...........PVVDLNRP R6CRU3_9FIRM/173-347 ..IKVGIAVV......YPT..TE.RDFYTLVTVGMGAHRMK........TPPELKT...EQL.ERAELVMYMP.PDWKPR....SRD............IRHSWIIKEMRRIARLPLENEARLPLENDTW....LGYGHL.V.SDG...SP.........IAP.NTEQEAILLISL........QDAPDAA.....L.RC.PLPNGES....................................VVF.YQLFPIYKQEMDYKLAR.....GAAALIDLMP.HIS...........AVYDPERE R7CX89_9BACE/155-325 .DIHVDIYIV......EPT..PE.RNYYTLVTGGMGARPMN........VPEELED...EEV.DRAELLITLP.PDWNLQ....SRD............ENDYWPIYWLKVLARLPIN.......E.NDW....LGYGHT.I.ETGEGDET.........IAP.DAPFQGLMLVTP........QEVPEAA.....H.TC.RLPNGDA....................................VRF.YQVIPLFKEEMDYKLDH.....DADALIDRME.HVS...........HVVNIYRK F9YUZ4_CAPCC/379-553 PDIHCDIYLI......KPT..PE.RNYYTLVTGGMGAFQMY........TPEDYHA......SPFAELVINLP.PTWNIQ....SEE............EKDYWPIRWLKNLARLPIQ.......H.QTY....LGYGHT.I.PTNDALE..............GTNFDCLMLIGA........VAQSEDGEQSQWA.VA.ELPSGKE....................................VGF.FYVVPLYPEETQFKLDQ.....SADDLLDKFE..VAD......IPYPPVVDINRV G8LYF9_CLOCD/37-211 DTVHIDIYHI......EPS..EE.RNYHTFVTMGMSSMPMN........VPKGQEE......WKFSELMICLP.ADWKVS....DKELKD.........NRNYWPLGLLKMLARFPHE.......Y.GTW....LSWGHT.M.PNGEPPQH.........YAD.NTKFCGIILLPP........ILVNEEF.....I.KL.KVNRNKT....................................INF.FAVIPLYKEEIDYKLEH.....GYNSFIEK....YAE......FDMDELIRLNRK #=GC seq_cons s.tslDllph.......s....t..sahpalThGhSch.hs.........stth.t.....pshthELshpLt............t.............t...WshthLpslAchshp........ttsh....ls.Gch.l...tt.shs.............ssphpthhlsp............ssph.....s.sl.ph.sup.....................................VpF.lpllPloppEhphtppp.....uspulhpp....hhp......tssh.lhDhpRt //