Summary: Herpes virus major outer envelope glycoprotein (BLLF1)
Herpes virus major outer envelope glycoprotein (BLLF1) Provide feedback
This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo .
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This tab holds annotation information from the InterPro database.
InterPro entry IPR007796
This family consists of the viral late glycoprotein BLLF1, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo. The binding of the viral major glycoprotein BLLF1 to the CD21 cellular receptor is thought to play an essential role during infection of B lymphocytes by the Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4) [PUBMED:11024143].
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|Cellular component||viral envelope (GO:0019031)|
|Biological process||viral infectious cycle (GO:0019058)|
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We make a range of alignments for each Pfam-A family:
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Curation and family details
|Seed source:||Pfam-B_6348 (release 7.7)|
|Number in seed:||3|
|Number in full:||270|
|Average length of the domain:||437.20 aa|
|Average identity of full alignment:||62 %|
|Average coverage of the sequence by the domain:||100.00 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||8|
|Download:||download the raw HMM for this family|
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Herpes_BLLF1 domain has been found. There are 1 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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