Summary: Aminopeptidase P, N-terminal domain
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Aminopeptidase P, N-terminal domain Provide feedback
Wilce MC, Bond CS, Dixon NE, Freeman HC, Guss JM, Lilley PE, Wilce JA; , Proc Natl Acad Sci U S A 1998;95:3472-3477.: Structure and mechanism of a proline-specific aminopeptidase from Escherichia coli. PUBMED:9520390 EPMC:9520390
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR007865
This entry represents the N-terminal domain of aminopeptidase P (X-Pro aminopeptidase I,II and III EC) and related sequences belonging to the peptidase M24B family. The domain is structurally very similar [PUBMED:9520390] to the creatinase N-terminal domain (INTERPRO), however, little or no sequence similarity exists between the two domains.
|Molecular function||aminopeptidase activity (GO:0004177)|
|manganese ion binding (GO:0030145)|
- the number of sequences which exhibit this architecture
a textual description of the architecture, e.g. Gla, EGF x 2, Trypsin.
This example describes an architecture with one
Gladomain, followed by two consecutive
EGFdomains, and finally a single
- the UniProt description of the protein sequence
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We make a range of alignments for each Pfam-A family:
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Curation and family details
|Number in seed:||154|
|Number in full:||2593|
|Average length of the domain:||135.80 aa|
|Average identity of full alignment:||28 %|
|Average coverage of the sequence by the domain:||29.60 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||11|
|Download:||download the raw HMM for this family|
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the AMP_N domain has been found. There are 51 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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