Summary: NDT80 / PhoG like DNA-binding family
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NDT80 / PhoG like DNA-binding family Provide feedback
This family includes the DNA-binding region of NDT80  as well as PhoG and its homologues. The family contains Q05534 or VIB-1. VIB-1 is thought to be a regulator of conidiation in Neurospora crassa and shares a region of similarity to PHOG, a possible phosphate nonrepressible acid phosphatase in Aspergillus nidulans. It has been found that vib-1 is not the structural gene for nonrepressible acid phosphatase, but rather may regulate nonrepressible acid phosphatase activity .
Montano SP, Pierce M, Cote ML, Vershon AK, Georgiadis MM; , Acta Crystallogr D Biol Crystallogr 2002;58:2127-2130.: Crystallographic studies of a novel DNA-binding domain from the yeast transcriptional activator Ndt80. PUBMED:12454476 EPMC:12454476
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR024061
The NDT80 DNA-binding domain is found in the following proteins, which might all be involved in sensing nutritional status [PUBMED:16464624]:
- Yeast meiosis-specific transcription factor NDT80, the key transcription factor that ultimately allows the continuation of meiosis after the successful completion of recombination.
- Emericella nidulans phoG (xprG), a transcriptional activator involved in the response to nutrient limitation.
- Emericella nidulans putative uncharacterised protein AN6015.2.
- Neurospora crassa transcription factor vib-1, involved in the control of heterokaryon incompatibility.
- Neurospora crassa related to acid phosphatase NCU04729.
- Neurospora crassa related to meiosis-specific protein NDT80 NCU09915.
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
|Molecular function||DNA binding (GO:0003677)|
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This clan contains a variety of DNA-binding domains that contain an immunoglobulin-like fold. It includes the DNA-binding domains of NF-kappaB, NFAT, p53, STAT-1, the T-domain and the Runt domain .
The clan contains the following 7 members:CEP1-DNA_bind NDT80_PhoG P53 RHD Runt STAT_bind T-box
We make a range of alignments for each Pfam-A family:
- the curated alignment from which the HMM for the family is built
- the alignment generated by searching the sequence database using the HMM
- Representative Proteomes (RPs) at 15%, 35%, 55% and 75% co-membership thresholds
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Curation and family details
|Seed source:||Wood V|
|Author:||Wood V, Bateman A, Glass NL, Moxon SJ|
|Number in seed:||16|
|Number in full:||421|
|Average length of the domain:||168.80 aa|
|Average identity of full alignment:||30 %|
|Average coverage of the sequence by the domain:||24.03 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||7|
|Download:||download the raw HMM for this family|
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the NDT80_PhoG domain has been found. There are 16 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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