Summary: CHASE3 domain
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CHASE3 is an extracellular sensory domain, which is present in various classes of transmembrane receptors that are parts of signal transduction pathways in bacteria. Specifically, CHASE3 domains are found in histidine kinases, adenylate cyclases, methyl-accepting chemotaxis proteins and predicted diguanylate cyclases/phosphodiesterases. Environmental factors that are recognised by CHASE3 domains are not known at this time .
Zhulin IB, Nikolskaya AN, Galperin MY; , J Bacteriol 2003;185:285-294.: Common extracellular sensory domains in transmembrane receptors for diverse signal transduction pathways in bacteria and archaea. PUBMED:12486065 EPMC:12486065
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This tab holds annotation information from the InterPro database.
InterPro entry IPR007891
CHASE3 is an extracellular sensory domain, which is present in various classes of transmembrane receptors that are upstream of signal transduction pathways in bacteria. Specifically, CHASE3 domains are found in histidine kinases, adenylate cyclases, methyl-accepting chemotaxis proteins and predicted diguanylate cyclases/phosphodiesterases. Environmental factors that are recognised by CHASE3 domains are not known at this time [PUBMED:12486065].
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This superfamily is characterised by a four-helix bundle structure that forms a ubiquitous sensory module in prokaryotic signal-transduction. The 4HB_MCP is always found between two predicted transmembrane helices indicating that it detects only extracellular signals. In many cases the domain is associated with a cytoplasmic HAMP domain suggesting that most proteins carrying the bundle might share the mechanism of transmembrane signalling which is well-characterised in E coli chemoreceptors.
The clan contains the following 3 members:4HB_MCP_1 CHASE3 TarH
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Curation and family details
|Seed source:||Ulrich L, Zhulin I|
|Author:||Ulrich L, Zhulin I|
|Number in seed:||180|
|Number in full:||1210|
|Average length of the domain:||135.90 aa|
|Average identity of full alignment:||19 %|
|Average coverage of the sequence by the domain:||20.96 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||8|
|Download:||download the raw HMM for this family|
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the CHASE3 domain has been found. There are 1 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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