Summary: Spore Coat Protein U domain
Spore Coat Protein U domain Provide feedback
This domain is found in a bacterial family of spore coat proteins  as well as a family of secreted pili proteins involved in motility and biofilm formation (). This family is distantly related to fimbrial proteins.
Tomaras AP, Dorsey CW, Edelmann RE, Actis LA; , Microbiology 2003;149:3473-3484.: Attachment to and biofilm formation on abiotic surfaces by Acinetobacter baumannii: involvement of a novel chaperone-usher pili assembly system. PUBMED:14663080 EPMC:14663080
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR007893
This domain is found in protein U, a spore coat protein produced at the late stage of development of Myxococcus xanthus. Protein U is produced as a secretory precursor, pro-protein U, which is then secreted across the membrane to assemble on the spore surface [PUBMED:1904442]. This domain is also found in a number of the genes within a conserved polycistronic operon that encodes a novel chaperone-usher pili assembly system. Examples are CsuA/B of Acinetobacter baumannii, and the CsuA, CsuB and CsuE of Vibrio parahaemolyticus and the related genes of Yersinia pestis.
In A. baumannii, csuC and csuE are required in the early steps of the process that that leads to biofilm formation. The conservation of the genes and gene order among unrelated bacteria, suggests that the csu operon is widespread and is involved in surface pilus formation which allows the bacteria to form biofilms on abiotic surfaces, a property that may aid there survival in their natural environment [PUBMED:14663080].
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This example describes an architecture with one
Gladomain, followed by two consecutive
EGFdomains, and finally a single
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This superfamily includes a variety of bacterial adhesins that have a jelly-roll beta-barrel fold . These domains are involved in sugar recognition.
The clan contains the following 7 members:Adhesin_Dr Collagen_bind Collagen_bind_2 DUF1120 Fimbrial PapG_N SCPU
We make a range of alignments for each Pfam-A family:
- the curated alignment from which the HMM for the family is built
- the alignment generated by searching the sequence database using the HMM
- Representative Proteomes (RPs) at 15%, 35%, 55% and 75% co-membership thresholds
- alignment generated by searching the NCBI sequence database using the family HMM
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Curation and family details
|Seed source:||Yeats C|
|Number in seed:||127|
|Number in full:||1343|
|Average length of the domain:||142.70 aa|
|Average identity of full alignment:||23 %|
|Average coverage of the sequence by the domain:||81.23 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||10|
|Download:||download the raw HMM for this family|
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