Summary: Flagellar transcriptional activator (FlhD)
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Flagellar transcriptional activator (FlhD) Provide feedback
This family consists of several bacterial flagellar transcriptional activator (FlhD) proteins. FlhD combines with FlhC to form a regulatory complex in E. coli, this complex has been shown to be a global regulator involved in many cellular processes as well as a flagellar transcriptional activator .
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This tab holds annotation information from the InterPro database.
InterPro entry IPR023559
This family consists of several bacterial flagellar transcriptional activator (FlhD) proteins. FlhD combines with FlhC to form a regulatory complex in Escherichia coli [PUBMED:11287152]. This complex has been shown to be a global transcriptional regulator involved in many cellular processes as well as a flagellar transcriptional activator [PUBMED:7961507, PUBMED:11169100, PUBMED:15941987].
The FlhD protein is dimeric. The dimer is tightly coupled, with an intimate contact surface, implying that the dimer does not easily dissociate. The FlhD monomer is predominantly alpha-helical [PUBMED:11169099].
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|Biological process||bacterial-type flagellum assembly (GO:0044780)|
|positive regulation of transcription, DNA-templated (GO:0045893)|
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Curation and family details
|Seed source:||Pfam-B_7623 (release 7.7)|
|Number in seed:||38|
|Number in full:||3587|
|Average length of the domain:||99.80 aa|
|Average identity of full alignment:||76 %|
|Average coverage of the sequence by the domain:||89.11 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 80369284 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||9|
|Download:||download the raw HMM for this family|
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There are 3 interactions for this family. More...
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the FlhD domain has been found. There are 10 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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