Summary: Herpesvirus glycoprotein L
Herpesvirus glycoprotein L Provide feedback
This family consists of several herpesvirus glycoprotein L or UL1 proteins. Glycoprotein L is known to form a complex with glycoprotein H but the function of this complex is poorly understood .
Lomonte P, Filee P, Lyaku JR, Bublot M, Pastoret PP, Thiry E; , J Gen Virol 1997;78:2015-2023.: Analysis of the biochemical properties of, and complex formation between, glycoproteins H and L of the gamma2 herpesvirus bovine herpesvirus-4. PUBMED:9267002 EPMC:9267002
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This tab holds annotation information from the InterPro database.
InterPro entry IPR007923
Herpesviruses are enveloped by a lipid bilayer that contains at least a dozen glycoproteins. The virion surface glycoproteins mediate recognition of susceptible cells and promote fusion of the viral envelope with the cell membrane, leading to virus entry. No single glycoprotein associated with the virion membrane has been identified as the fusogen [PUBMED:17299053].
Glycoprotein L (gL) forms a non-covalently linked heterodimer with glycoprotein H (gH). This heterodimer is essential for virus-cell and cell-cell fusion since the association of gH and gL is necessary for correct localisation of gH to the virion or cell surface. gH anchoring the heterodimer to the plasma membrane through its transmembrane domain. gL lacks a transmembrane domain and is secreted from cells when expressed in the absence of gH [PUBMED:7769724].
This entry represents Herpesvirus glycoprotein L (gL), which is a virion associated envelope glycoprotein [PUBMED:9526546]. Heterodimer formation between gH and gL has been demonstrated in both virions and infected cells [PUBMED:9267002]. Heterodimer formation between gL and gH is important for the proper folding of gH and its insertion into the membrane because the anti-gH conformation-dependent monoclonal antibodies (mAbs) 53S and LP11 bind gH only when gL is present [PUBMED:3016991, PUBMED:2552150].
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Curation and family details
|Seed source:||Pfam-B_7535 (release 7.7)|
|Number in seed:||14|
|Number in full:||77|
|Average length of the domain:||104.90 aa|
|Average identity of full alignment:||33 %|
|Average coverage of the sequence by the domain:||53.27 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||6|
|Download:||download the raw HMM for this family|
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Herpes_UL1 domain has been found. There are 1 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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