Summary: Neuroendocrine protein 7B2 precursor (Secretogranin V)
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Neuroendocrine protein 7B2 precursor (Secretogranin V) Provide feedback
The neuroendocrine protein 7B2 has a critical role in the proteolytic conversion and activation of proPC2, the enzyme responsible for the proteolytic conversion of many peptide hormone precursors. The 7B2 protein acts as an intracellular binding protein for proPC2, facilitates its maturation, and is required for its enzymatic activity. Processing of many important peptide precursors does not occur in 7B2 nulls. 7B2 null mice exhibit a unique form of Cushing's disease with many atypical symptoms, such as hypoglycemia [1].
Literature references
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Sarac MS, Zieske AW, Lindberg I; , Endocrinology 2002;143:2324-2332.: The lethal form of Cushing's in 7B2 null mice is caused by multiple metabolic and hormonal abnormalities. PUBMED:12021197 EPMC:12021197
This tab holds annotation information from the InterPro database.
InterPro entry IPR007945
Prohormone convertases (PCs) 1 and 2 are a family of eukaryotic subtilisins thought to mediate the proteolytic cleavage of many peptide precursors [PUBMED:10701998]. Protein 7B2 (secretogranin V) functions as a molecular chaperone for PC2, preventing its premature activation in the regulated secretory pathway [PUBMED:7913882]. 7B2 represents a potent inhibitor of PC2, and it is also required for the activation of PC2, which is synthesised as a zymogen. Protein 7B2 has an N-terminal activation domain and a C-terminal (CT) inhibitory domain (MEROPS inhibitor family I21), separated by a furin cleavage site [PUBMED:10506829]. 7B2 is synthesised as a precursor protein that is cleaved into the N-terminal fragment and the C-terminal peptide [PUBMED:11439082].
Gene Ontology
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
Cellular component | secretory granule (GO:0030141) |
Biological process | neuropeptide signaling pathway (GO:0007218) |
Domain organisation
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Alignments
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Seed (7) |
Full (226) |
Representative proteomes | UniProt (403) |
NCBI (581) |
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RP15 (61) |
RP35 (112) |
RP55 (175) |
RP75 (206) |
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PP/heatmap | 1 |
1Cannot generate PP/Heatmap alignments for seeds; no PP data available
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Seed (7) |
Full (226) |
Representative proteomes | UniProt (403) |
NCBI (581) |
Meta (0) |
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RP15 (61) |
RP35 (112) |
RP55 (175) |
RP75 (206) |
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Gzipped |
You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.
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Curation and family details
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Curation
Seed source: | Pfam-B_6776 (release 7.7) |
Previous IDs: | none |
Type: | Family |
Author: | Moxon SJ |
Number in seed: | 7 |
Number in full: | 226 |
Average length of the domain: | 165.20 aa |
Average identity of full alignment: | 35 % |
Average coverage of the sequence by the domain: | 67.58 % |
HMM information
HMM build commands: |
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 26740544 -E 1000 --cpu 4 HMM pfamseq
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Model details: |
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Model length: | 227 | ||||||||||||
Family (HMM) version: | 10 | ||||||||||||
Download: | download the raw HMM for this family |
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