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0  structures 200  species 0  interactions 245  sequences 7  architectures

Family: CRF-BP (PF05428)

Summary: Corticotropin-releasing factor binding protein (CRF-BP)

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This is the Wikipedia entry entitled "Corticotropin-releasing hormone binding protein family". More...

Corticotropin-releasing hormone binding protein family Edit Wikipedia article

Corticotropin-releasing factor binding protein (CRF-BP)
Identifiers
Symbol CRF-BP
Pfam PF05428
InterPro IPR008435

Corticotropin-releasing factor binding protein family consists of several eukaryotic corticotropin-releasing factor binding proteins (CRF-BP or CRH-BP).

Corticotropin-releasing hormone (CRH) plays multiple roles in vertebrate species. In mammals, it is the major hypothalamic releasing factor for pituitary adrenocorticotropin secretion, and is a neurotransmitter or neuromodulator at other sites in the central nervous system. In non-mammalian vertebrates, CRH not only acts as a neurotransmitter and hypophysiotropin, it also acts as a potent thyrotropin-releasing factor, allowing CRH to regulate both the adrenal and thyroid axes, especially in development.

Corticotropin-releasing factor binding protein (CRH-BP) is thought to play an inhibitory role in which it binds CRH and other CRH-like ligands and prevents the activation of CRH receptors. There is however evidence that CRH-BP may also exhibit diverse extra and intracellular roles in a cell specific fashion and at specific times in development.[1]

Human proteins

CRHBP;

References

  1. ^ Seasholtz AF, Valverde RA, Denver RJ (2002). "Corticotropin-releasing hormone-binding protein: biochemistry and function from fishes to mammals". J. Endocrinol. 175 (1): 89–97. doi:10.1677/joe.0.1750089. PMID 12379493. 

This article incorporates text from the public domain Pfam and InterPro IPR008435

This page is based on a Wikipedia article. The text is available under the Creative Commons Attribution/Share-Alike License.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Corticotropin-releasing factor binding protein (CRF-BP) Provide feedback

This family consists of several eukaryotic corticotropin-releasing factor binding proteins (CRF-BP or CRH-BP). Corticotropin-releasing hormone (CRH) plays multiple roles in vertebrate species. In mammals, it is the major hypothalamic releasing factor for pituitary adrenocorticotropin secretion, and is a neurotransmitter or neuromodulator at other sites in the central nervous system. In non-mammalian vertebrates, CRH not only acts as a neurotransmitter and hypophysiotropin, it also acts as a potent thyrotropin-releasing factor, allowing CRH to regulate both the adrenal and thyroid axes, especially in development. CRH-BP is thought to play an inhibitory role in which it binds CRH and other CRH-like ligands and prevents the activation of CRH receptors. There is however evidence that CRH-BP may also exhibit diverse extra and intracellular roles in a cell specific fashion and at specific times in development [1].

Literature references

  1. Seasholtz AF, Valverde RA, Denver RJ; , J Endocrinol 2002;175:89-97.: Corticotropin-releasing hormone-binding protein: biochemistry and function from fishes to mammals. PUBMED:12379493 EPMC:12379493


This tab holds annotation information from the InterPro database.

InterPro entry IPR008435

This family consists of several eukaryotic corticotropin-releasing factor binding proteins (CRF-BP or CRH-BP). Corticotropin-releasing hormone (CRH) plays multiple roles in vertebrate species. In mammals, it is the major hypothalamic releasing factor for pituitary adrenocorticotropin secretion, and is a neurotransmitter or neuromodulator at other sites in the central nervous system. In non-mammalian vertebrates, CRH not only acts as a neurotransmitter and hypophysiotropin, it also acts as a potent thyrotropin-releasing factor, allowing CRH to regulate both the adrenal and thyroid axes, especially in development. CRH-BP is thought to play an inhibitory role in which it binds CRH and other CRH-like ligands and prevents the activation of CRH receptors. There is however evidence that CRH-BP may also exhibit diverse extra and intracellular roles in a cell specific fashion and at specific times in development [PUBMED:12379493].

Gene Ontology

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Domain organisation

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(16)
Full
(245)
Representative proteomes UniProt
(395)
NCBI
(593)
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RP15
(61)
RP35
(107)
RP55
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RP75
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  Seed
(16)
Full
(245)
Representative proteomes UniProt
(395)
NCBI
(593)
Meta
(0)
RP15
(61)
RP35
(107)
RP55
(199)
RP75
(239)
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  Seed
(16)
Full
(245)
Representative proteomes UniProt
(395)
NCBI
(593)
Meta
(0)
RP15
(61)
RP35
(107)
RP55
(199)
RP75
(239)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download   Download    
Gzipped Download   Download   Download   Download   Download   Download   Download   Download    

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

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This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

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Curation and family details

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Curation View help on the curation process

Seed source: Pfam-B_11928 (release 8.0)
Previous IDs: none
Type: Family
Sequence Ontology: SO:0100021
Author: Moxon SJ
Number in seed: 16
Number in full: 245
Average length of the domain: 262.90 aa
Average identity of full alignment: 43 %
Average coverage of the sequence by the domain: 84.73 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 45638612 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 25.0 25.0
Trusted cut-off 25.0 25.1
Noise cut-off 23.1 22.1
Model length: 307
Family (HMM) version: 11
Download: download the raw HMM for this family

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