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0  structures 96  species 0  interactions 139  sequences 5  architectures

Family: BSP_II (PF05432)

Summary: Bone sialoprotein II (BSP-II)

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This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Bone sialoprotein II (BSP-II) Provide feedback

Bone sialoprotein (BSP) is a major structural protein of the bone matrix that is specifically expressed by fully-differentiated osteoblasts [1]. The expression of bone sialoprotein (BSP) is normally restricted to mineralised connective tissues of bones and teeth where it has been associated with mineral crystal formation. However, it has been found that ectopic expression of BSP occurs in various lesions, including oral and extraoral carcinomas, in which it has been associated with the formation of microcrystalline deposits and the metastasis of cancer cells to bone [2].

Literature references

  1. Kim RH, Shapiro HS, Li JJ, Wrana JL, Sodek J; , Matrix Biol 1994;14:31-40.: Characterization of the human bone sialoprotein (BSP) gene and its promoter sequence. PUBMED:8061918 EPMC:8061918

  2. Sasaguri K, Ganss B, Sodek J, Chen JK; , Arch Oral Biol 2000;45:551-562.: Expression of bone sialoprotein in mineralized tissues of tooth and bone and in buccal-pouch carcinomas of Syrian golden hamsters. PUBMED:10785518 EPMC:10785518


This tab holds annotation information from the InterPro database.

InterPro entry IPR008412

The major non-collagenous matrix proteins (chondroitin-sulphate glycoproteins decorin and biglycan, sialoproteins osteopontin and bone sialoprotein, osteocalcin and osteonectin) have important roles in formation and organisation of the collagen matrix and nucleation and growth of hydroxyapatite crystals.

Bone sialoprotein (BSP) is a major structural protein of the bone matrix that is specifically expressed by fully differentiated osteoblasts [PUBMED:8061918], [PUBMED:10759428] and is highly specific for mineralising tissues. The expression of bone sialoprotein (BSP) is normally restricted to mineralised connective tissues of bones and teeth; it is thought to be responsible for nucleation of hydroxyapatite crystals. BSP also displays a high affinity for calcium ions. The mature protein has a molecular weight of around 33 kDa and consists predominantly of Glu and Gly residues. It is subject to extensive posttranslational modification, and is predominantly phosphorylated at Ser residues. Posttranslational modifications can also cause BSP to act as an inhibitor of hydroxyapatite crystal formation. Ectopic expression of BSP occurs in various lesions, including oral and extraoral carcinomas, in which it has been associated with the formation of microcrystalline deposits and the metastasis of cancer cells to bone [PUBMED:10785518].

This entry represents the bone sialoprotein II group of proteins.

Gene Ontology

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Domain organisation

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Alignments

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  Seed
(16)
Full
(139)
Representative proteomes UniProt
(169)
NCBI
(341)
Meta
(0)
RP15
(14)
RP35
(37)
RP55
(110)
RP75
(134)
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Key: ✓ available, x not generated, not available.

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  Seed
(16)
Full
(139)
Representative proteomes UniProt
(169)
NCBI
(341)
Meta
(0)
RP15
(14)
RP35
(37)
RP55
(110)
RP75
(134)
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  Seed
(16)
Full
(139)
Representative proteomes UniProt
(169)
NCBI
(341)
Meta
(0)
RP15
(14)
RP35
(37)
RP55
(110)
RP75
(134)
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You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

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Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Pfam-B_12103 (release 8.0)
Previous IDs: none
Type: Family
Sequence Ontology: SO:0100021
Author: Moxon SJ
Number in seed: 16
Number in full: 139
Average length of the domain: 203.80 aa
Average identity of full alignment: 44 %
Average coverage of the sequence by the domain: 84.49 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 45638612 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 25.1 25.1
Trusted cut-off 25.2 25.2
Noise cut-off 25.0 25.0
Model length: 301
Family (HMM) version: 11
Download: download the raw HMM for this family

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