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0  structures 234  species 0  interactions 319  sequences 4  architectures

Family: TRH (PF05438)

Summary: Thyrotropin-releasing hormone (TRH)

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This is the Wikipedia entry entitled "Thyrotropin-releasing hormone". More...

Thyrotropin-releasing hormone Edit Wikipedia article

Thyrotropin-releasing hormone (TRH) is a tripeptide hormone produced by the hypothalamus and stimulating production of TSH and prolactin by the anterior lobe of the pituitary. It is passed from hypothalamus (eminentia mediana) to the pituitary by the means of the pituitary portal system. The sequence of TRH was first determined and the hormone was synthetised by Roger Guillemin and Andrew V. Schally in 1969. The presence of TRH can also be detected in other parts of the brain, in the gastrointestinal system and pancreatic islets. Medical preparations of TRH are used in diagnostic tests of thyroid disorders and in acromegly.

Structure : (pyro)Glu-His-Pro-NH2
Molecular weight : 359,5 D

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This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Thyrotropin-releasing hormone (TRH) Provide feedback

This family consists of several thyrotropin-releasing hormone (TRH) proteins. Thyrotropin-Releasing Hormone (TRH; pyroGlu-His-Pro-NH2), originally isolated as a hypothalamic neuropeptide hormone, most likely acts also as a neuromodulator and/or neurotransmitter in the central nervous system (CNS). This interpretation is supported by the identification of a peptidase localised on the surface of neuronal cells which has been termed TRH-degrading ectoenzyme (TRH-DE) since it selectively inactivates TRH [1]. TRH has been used clinically for the treatment of spinocerebellar degeneration and disturbance of consciousness in humans [2].

Literature references

  1. Heuer H, Schafer MK, Bauer K; , Acta Med Austriaca 1999;26:119-122.: Thyrotropin-releasing hormone (TRH), a signal peptide of the central nervous system. PUBMED:10526628 EPMC:10526628

  2. Urayama A, Yamada S, Kimura R, Zhang J, Watanabe Y; , Life Sci 2002;72:601-607.: Neuroprotective effect and brain receptor binding of taltirelin, a novel thyrotropin-releasing hormone (TRH) analogue, in transient forebrain ischemia of C57BL/6J mice. PUBMED:12467901 EPMC:12467901

This tab holds annotation information from the InterPro database.

InterPro entry IPR008857

This family consists of several thyrotropin-releasing hormone (TRH) proteins. Thyrotropin-Releasing Hormone (TRH) is a tripeptide (pGlu-His-Pro-NH2) hormone that is primarily produced in the paraventricular nucleus of the hypothalamus and represents the most proximal member of the hypothalamic-pituitary-thyroid (HPT) axis. It plays an important role in maintaining the thyroid hormone (TH) homeostasis [ PUBMED:19179434 ].

Gene Ontology

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Domain organisation

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You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

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This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

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Curation and family details

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Seed source: Pfam-B_14384 (release 8.0)
Previous IDs: none
Type: Family
Sequence Ontology: SO:0100021
Author: Moxon SJ
Number in seed: 13
Number in full: 319
Average length of the domain: 179.8 aa
Average identity of full alignment: 42 %
Average coverage of the sequence by the domain: 80.17 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 27.8 27.8
Trusted cut-off 31.7 28.3
Noise cut-off 25.4 27.4
Model length: 221
Family (HMM) version: 15
Download: download the raw HMM for this family

Species distribution

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
P01150 View 3D Structure Click here
P20396 View 3D Structure Click here
Q5EDF9 View 3D Structure Click here
Q5KT10 View 3D Structure Click here
Q62361 View 3D Structure Click here
Q6ZXC3 View 3D Structure Click here

trRosetta Structure

The structural model below was generated by the Baker group with the trRosetta software using the Pfam UniProt multiple sequence alignment.

The InterPro website shows the contact map for the Pfam SEED alignment. Hovering or clicking on a contact position will highlight its connection to other residues in the alignment, as well as on the 3D structure.

Improved protein structure prediction using predicted inter-residue orientations. Jianyi Yang, Ivan Anishchenko, Hahnbeom Park, Zhenling Peng, Sergey Ovchinnikov, David Baker Proceedings of the National Academy of Sciences Jan 2020, 117 (3) 1496-1503; DOI: 10.1073/pnas.1914677117;