Summary: RanGTP-binding protein
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The small Ras-like GTPase Ran plays an essential role in the transport of macromolecules in and out of the nucleus and has been implicated in spindle and nuclear envelope formation during mitosis in higher eukaryotes. The S. cerevisiae ORF YGL164c encoding a novel RanGTP-binding protein, termed Yrb30p was identified. The protein competes with yeast RanBP1 (Yrb1p) for binding to the GTP-bound form of yeast Ran (Gsp1p) and is, like Yrb1p, able to form trimeric complexes with RanGTP and some of the karyopherins .
Braunwarth A, Fromont-Racine M, Legrain P, Bischoff FR, Gerstberger T, Hurt E, Kunzler M; , J Biol Chem 2003;0:0-0.: Identification and characterization of a novel RanGTP-binding protein in the yeast Saccharomyces cerevisiae. PUBMED:12578832 EPMC:12578832
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This tab holds annotation information from the InterPro database.
InterPro entry IPR008812The small Ras-like GTPase Ran plays an essential role in the transport of macromolecules in and out of the nucleus and has been implicated in spindle and nuclear envelope formation during mitosis in higher eukaryotes. The Saccharomyces cerevisiae ORF YGL164c encoding a novel RanGTP-binding protein, termed Yrb30p was identified. The protein competes with S. cerevisiae RanBP1 (Yrb1p) for binding to the GTP-bound form of S. cerevisiae Ran (Gsp1p) and is, like Yrb1p, able to form trimeric complexes with RanGTP and some of the karyopherins [PUBMED:12578832].
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Curation and family details
|Seed source:||Pfam-B_37054 (release 8.0)|
|Number in seed:||18|
|Number in full:||126|
|Average length of the domain:||299.00 aa|
|Average identity of full alignment:||40 %|
|Average coverage of the sequence by the domain:||58.01 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||6|
|Download:||download the raw HMM for this family|
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