# STOCKHOLM 1.0 #=GF ID Bap31 #=GF AC PF05529.13 #=GF DE Bap31/Bap29 transmembrane region #=GF AU Finn RD;0000-0001-8626-2148 #=GF AU Bateman A;0000-0002-6982-4660 #=GF SE Pfam-B_6449 (release 8.0) #=GF GA 22.70 22.70; #=GF TC 22.70 22.70; #=GF NC 22.60 22.60; #=GF BM hmmbuild HMM.ann SEED.ann #=GF SM hmmsearch --cut_ga HMM metaseq #=GF TP Family #=GF RN [1] #=GF RM 11917123 #=GF RT The procaspase-8 isoform, procaspase-8L, recruited to the BAP31 #=GF RT complex at the endoplasmic reticulum. #=GF RA Breckenridge DG, Nguyen M, Kuppig S, Reth M, Shore GC; #=GF RL Proc Natl Acad Sci U S A 2002;99:4331-4336. #=GF DR INTERPRO; IPR040463; #=GF DR SO; 0100021; polypeptide_conserved_region; #=GF CC Bap31 is a polytopic integral protein of the endoplasmic #=GF CC reticulum membrane and a substrate of caspase-8. Bap31 is #=GF CC cleaved within its cytosolic domain, generating pro-apoptotic #=GF CC p20 Bap31 [1]. This family also contains the Bap29 protein that #=GF CC forms a heterodimer with Bap 31. #=GF SQ 1 #=GS EBL28299.1/82-209 DE [subseq from] hypothetical protein GOS_8596608 [marine metagenome] EBL28299.1/82-209 ----FEVIFILLCVEGAITTLLVAPLPPSVRGYLVRWLSDSSALASLARPLAYFVAVLVLAWVFVSVELMQLQTEYDTE--VKLAMDLGRKLQHESRMFRAQRNFYLTGFCALLLVVIARLYQLLKEANQLAAK---- #=GC PP_cons ....689********************************9998888887777666666666555555677777777777..5789******************************************9998876.... #=GC RF xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx //