Summary: galactosyl transferase GMA12/MNN10 family
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galactosyl transferase GMA12/MNN10 family Provide feedback
This family contains a number of glycosyltransferase enzymes that contain a DXD motif. This family includes a number of C. elegans homologues where the DXD is replaced by DXH. Some members of this family are included in glycosyltransferase family 34.
Chappell TG, Hajibagheri MA, Ayscough K, Pierce M, Warren G; , Mol Biol Cell 1994;5:519-528.: Localization of an alpha 1,2 galactosyltransferase activity to the Golgi apparatus of Schizosaccharomyces pombe. PUBMED:7522655 EPMC:7522655
Yoko-o T, Roy SK, Jigami Y; , Eur J Biochem 1998;257:630-637.: Differences in in vivo acceptor specificity of two galactosyltransferases, the gmh3+ and gma12+ gene products from Schizosaccharomyces pombe. PUBMED:9839953 EPMC:9839953
Internal database links
|Similarity to PfamA using HHSearch:||DUF273 Nucleotid_trans|
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR008630This family contains a number of glycosyltransferase enzymes that contain a DXD motif. This family includes a number of Caenorhabditis elegans homologues where the DXD is replaced by DXH. Some members of this family are included in glycosyltransferase family 34.
|Cellular component||integral component of membrane (GO:0016021)|
|Molecular function||transferase activity, transferring hexosyl groups (GO:0016758)|
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This is the GT-A clan that contains diverse glycosyltransferases that possess a Rossmann like fold .
The clan contains the following 46 members:Anp1 Caps_synth Cellulose_synt CgtA CHGN Chitin_synth_1 Chitin_synth_2 CofC CTP_transf_3 DUF2064 DUF273 DUF604 Fringe Galactosyl_T GlcNAc Gly_transf_sug Glyco_tranf_2_2 Glyco_tranf_2_3 Glyco_tranf_2_4 Glyco_tranf_2_5 Glyco_trans_2_3 Glyco_transf_15 Glyco_transf_21 Glyco_transf_25 Glyco_transf_34 Glyco_transf_43 Glyco_transf_49 Glyco_transf_6 Glyco_transf_64 Glyco_transf_7C Glyco_transf_7N Glyco_transf_8 Glyco_transf_92 Glycos_transf_2 GNT-I IspD Mannosyl_trans3 MGAT2 NTP_transf_3 NTP_transferase Nucleotid_trans Osmo_MPGsynth Pox_P35 Rhamno_transf TcdA_TcdB UDPGP
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Curation and family details
|Seed source:||Pfam-B_6000 (release 8.0)|
|Number in seed:||14|
|Number in full:||1279|
|Average length of the domain:||209.40 aa|
|Average identity of full alignment:||22 %|
|Average coverage of the sequence by the domain:||55.38 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 80369284 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||8|
|Download:||download the raw HMM for this family|
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Glyco_transf_34 domain has been found. There are 4 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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