Summary: Cna protein B-type domain
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Cna protein B-type domain Provide feedback
This domain is found in Staphylococcus aureus collagen-binding surface protein. However, this region does not mediate collagen binding, the PF05737 region carries out that function. The structure of the repetitive B-region has been solved  and forms a beta sandwich structure. It is thought that this region forms a stalk in Staphylococcus aureus collagen-binding protein that presents the ligand binding domain away from the bacterial cell surface.
Deivanayagam CC, Rich RL, Carson M, Owens RT, Danthuluri S, Bice T, Hook M, Narayana SV; , Structure Fold Des 2000;8:67-78.: Novel fold and assembly of the repetitive B region of the Staphylococcus aureus collagen-binding surface protein. PUBMED:10673425 EPMC:10673425
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This tab holds annotation information from the InterPro database.
InterPro entry IPR008454
This entry represents a repeated B region domain found in the collagen-binding surface protein Cna in Staphylococcus aureus, as well as other related domains. The B region domain of Cna has a prealbumin-like beta-sandwich fold of seven strands in two sheets with a Greek key topology [PUBMED:10673425]. However, this domain does not mediate collagen binding, the INTERPRO region carries out that function; instead it appears to form a stalk that presents the ligand binding domain away from the bacterial cell surface. Cna is a collagen-binding MSCRAMM (Microbial Surface Component Recognizing Adhesive Matrix Molecules), and is necessary and sufficient for S. aureus cells to adhere to cartilage.
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This clan unifies several SCOP superfamilies that all share a 7 stranded beta sandwich fold.
The clan contains the following 13 members:CarboxypepD_reg Cna_B Dioxygenase_C DUF1416 DUF2012 DUF2606 DUF3823 DUF4480 FctA fn3_3 PEGA phage_tail_N Transthyretin
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Curation and family details
|Seed source:||Pfam-B_366 (release 8.0)|
|Number in seed:||135|
|Number in full:||13573|
|Average length of the domain:||73.40 aa|
|Average identity of full alignment:||23 %|
|Average coverage of the sequence by the domain:||22.10 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||8|
|Download:||download the raw HMM for this family|
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There are 2 interactions for this family. More...
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Cna_B domain has been found. There are 80 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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