# STOCKHOLM 1.0 #=GF ID RusA #=GF AC PF05866.14 #=GF DE Endodeoxyribonuclease RusA #=GF AU Moxon SJ;0000-0003-4644-1816 #=GF SE Pfam-B_8996 (release 8.0) #=GF GA 22.80 22.80; #=GF TC 22.80 22.80; #=GF NC 22.70 22.50; #=GF BM hmmbuild HMM.ann SEED.ann #=GF SM hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq #=GF TP Family #=GF RN [1] #=GF RM 8648624 #=GF RT Holliday junction resolvases encoded by homologous rusA genes in #=GF RT Escherichia coli K-12 and phage 82. #=GF RA Mahdi AA, Sharples GJ, Mandal TN, Lloyd RG; #=GF RL J Mol Biol 1996;257:561-573. #=GF RN [2] #=GF RM 7813450 #=GF RT Processing of intermediates in recombination and DNA repair: #=GF RT identification of a new endonuclease that specifically cleaves #=GF RT Holliday junctions. #=GF RA Sharples GJ, Chan SN, Mahdi AA, Whitby MC, Lloyd RG; #=GF RL EMBO J 1994;13:6133-6142. #=GF DR INTERPRO; IPR008822; #=GF DR SCOP; 1q8r; fa; #=GF DR SO; 0100021; polypeptide_conserved_region; #=GF CC This family consists of several bacterial and phage Holliday #=GF CC junction resolvase (RusA) like proteins. The RusA protein of #=GF CC Escherichia coli is an endonuclease that can resolve Holliday #=GF CC intermediates and correct the defects in genetic recombination #=GF CC and DNA repair associated with inactivation of RuvAB or RuvC #=GF CC [1,2]. #=GF SQ 1574 #=GS A0A410DQF5_9CLOT/11-126 AC A0A410DQF5.1 #=GS A0A4Z0L4E1_SALET/6-119 AC A0A4Z0L4E1.1 #=GS A0A1E7F323_9STRA/2-144 AC A0A1E7F323.1 #=GS A0A1H6CRC9_9SPHI/3-115 AC A0A1H6CRC9.1 #=GS A0A4Y7RBV1_9FIRM/9-129 AC A0A4Y7RBV1.1 #=GS Q2NPB1_9CAUD/17-126 AC Q2NPB1.1 #=GS A0A0D8ZYJ5_9CYAN/10-103 AC A0A0D8ZYJ5.1 #=GS A0A1I5DGB5_9FLAO/28-125 AC A0A1I5DGB5.1 #=GS B2JU78_PARP8/29-153 AC B2JU78.1 #=GS A0A653FRF1_9CAUD/9-115 AC A0A653FRF1.1 #=GS A0A449BEW3_ACHAX/9-128 AC A0A449BEW3.1 #=GS L0A0Y4_DEIPD/49-153 AC L0A0Y4.1 #=GS R7GJW3_9CLOT/7-133 AC R7GJW3.1 #=GS I4VMW7_9GAMM/42-170 AC I4VMW7.1 #=GS A0A3G8F7D4_9CAUD/6-150 AC A0A3G8F7D4.1 #=GS A0A2U8UVA8_9CAUD/7-134 AC A0A2U8UVA8.1 #=GS A0A386PH24_CLOSE/10-125 AC A0A386PH24.1 #=GS V6IVF9_9BACL/7-134 AC V6IVF9.1 #=GS A0A3G8FDG9_9CAUD/6-150 AC A0A3G8FDG9.1 #=GS A0A264W7D7_9BACL/12-139 AC A0A264W7D7.1 #=GS D7RWN7_9CAUD/6-135 AC D7RWN7.1 #=GS S5MDR3_9CAUD/6-119 AC S5MDR3.1 #=GS A0A385D014_9CAUD/40-144 AC A0A385D014.1 #=GS G8AYG1_9PROT/9-115 AC G8AYG1.1 #=GS A0A1B1IMR8_9CAUD/13-131 AC A0A1B1IMR8.2 #=GS D3DIN5_HYDTT/8-115 AC D3DIN5.1 #=GS A0A223LGS0_9CAUD/16-134 AC A0A223LGS0.1 #=GS A0A377I264_HAEPH/12-119 AC A0A377I264.1 #=GS C6PVY6_9CLOT/11-126 AC C6PVY6.1 #=GS A0A5J6TLY9_9CAUD/71-208 AC A0A5J6TLY9.1 #=GS A0A0M2PVD4_PROHO/9-103 AC A0A0M2PVD4.1 #=GS A0A286QP71_9CAUD/6-150 AC A0A286QP71.1 #=GS A0A074LIA8_9BACL/6-120 AC A0A074LIA8.1 #=GS X2CXX1_9CAUD/8-148 AC X2CXX1.1 #=GS A0A649V0U3_9CAUD/14-132 AC A0A649V0U3.1 #=GS A0A223SDN9_9ACTN/1-115 AC A0A223SDN9.1 #=GS A0A519IVW7_9CAUL/27-114 AC A0A519IVW7.1 #=GS A0A1M5JH35_9FIRM/19-132 AC A0A1M5JH35.1 #=GS A0A1I1DHM3_9BURK/7-110 AC A0A1I1DHM3.1 #=GS A0A0J1GIP1_9GAMM/24-132 AC A0A0J1GIP1.1 #=GS A0A0G3BN68_9BURK/1-109 AC A0A0G3BN68.1 #=GS A0A4D6ABG1_9CAUD/1-91 AC A0A4D6ABG1.1 #=GS N9WVZ8_CLOIN/7-124 AC N9WVZ8.1 #=GS A0A0A6PAF2_9GAMM/12-109 AC A0A0A6PAF2.1 #=GS A6VNN8_ACTSZ/10-116 AC A6VNN8.1 #=GS A0A5C5YAX3_9PLAN/43-149 AC A0A5C5YAX3.1 #=GS A0A257J7L0_9PROT/27-115 AC A0A257J7L0.1 #=GS A0A3G8F6Q8_9CAUD/6-150 AC A0A3G8F6Q8.1 #=GS A0A084UDL7_9RHIZ/7-115 AC A0A084UDL7.1 #=GS A0A7G3RZD6_9CAUD/6-119 AC A0A7G3RZD6.1 #=GS A0A3G3M3H5_9CAUD/11-135 AC A0A3G3M3H5.1 #=GS A0A0M2PXT7_PROHO/9-102 AC A0A0M2PXT7.1 #=GS A0A5J6TNX1_9CAUD/71-208 AC A0A5J6TNX1.1 #=GS A0A7C9RJN2_9BRAD/15-118 AC A0A7C9RJN2.1 #=GS Q832U0_ENTFA/6-135 AC Q832U0.1 #=GS U2TUU7_9ACTN/29-119 AC U2TUU7.1 #=GS A0A2A2TCN5_9CYAN/5-108 AC A0A2A2TCN5.1 #=GS A0A1W1VWV6_9THEO/22-129 AC A0A1W1VWV6.1 #=GS A8AHP7_CITK8/4-115 AC A8AHP7.1 #=GS B5LKT6_9CAUD/11-143 AC B5LKT6.1 #=GS A0A3G8F805_9CAUD/6-150 AC A0A3G8F805.1 #=GS R6DY56_9BACT/8-117 AC R6DY56.1 #=GS A0A430AVY7_9ENTE/13-126 AC A0A430AVY7.1 #=GS A0A3T1D2L8_9BACL/2-106 AC A0A3T1D2L8.1 #=GS W1TM56_9ACTO/17-143 AC W1TM56.1 #=GS A0A5Q2F669_9CAUD/12-140 AC A0A5Q2F669.1 #=GS D2IZE1_9CAUD/6-135 AC D2IZE1.1 #=GS A0A1V4INV7_9CLOT/10-125 AC A0A1V4INV7.1 #=GS A0A1D7XM33_9CLOT/6-129 AC A0A1D7XM33.1 #=GS K9VKB1_9CYAN/8-99 AC K9VKB1.1 #=GS A0A653FVS1_9CAUD/9-115 AC A0A653FVS1.1 #=GS A0A5C5WK94_9BACT/7-113 AC A0A5C5WK94.1 #=GS A0A1I1IER5_9CLOT/10-125 AC A0A1I1IER5.1 #=GS H0A2S0_9PROT/30-155 AC H0A2S0.1 #=GS A0A3G1E3L4_9CAUD/8-144 AC A0A3G1E3L4.1 #=GS F2KS15_ARCVS/2-79 AC F2KS15.1 #=GS A0A2I5T8H4_SERS3/5-115 AC A0A2I5T8H4.1 #=GS C7JAN3_ACEP3/16-139 AC C7JAN3.1 #=GS A0A2S9QMY6_9MICO/30-137 AC A0A2S9QMY6.1 #=GS T2FIG6_9CAUD/11-143 AC T2FIG6.1 #=GS D9QJA0_BRESC/27-114 AC D9QJA0.1 #=GS A0A2D1GQ71_9CAUD/7-130 AC A0A2D1GQ71.1 #=GS A0A1U9KC26_9BACL/6-114 AC A0A1U9KC26.1 #=GS K6U5K5_9CLOT/5-128 AC K6U5K5.1 #=GS A0A6N9Q8T4_9BACL/7-134 AC A0A6N9Q8T4.1 #=GS K9VX03_9CYAN/164-276 AC K9VX03.1 #=GS A0A482IJG5_9CAUD/4-115 AC A0A482IJG5.1 #=GS G8QMM9_AZOOP/13-141 AC G8QMM9.1 #=GS A0A4D6AHX3_9CAUD/9-129 AC A0A4D6AHX3.1 #=GS A0A3G8F4S4_9CAUD/6-136 AC A0A3G8F4S4.1 #=GS U2L7W7_9FIRM/9-127 AC U2L7W7.1 #=GS A0A5P8PI14_9CAUD/117-227 AC A0A5P8PI14.1 #=GS A0A4S2DGK9_9CLOT/10-125 AC A0A4S2DGK9.1 #=GS V2UPI4_9GAMM/57-157 AC V2UPI4.1 #=GS A0A4V3EVB7_9CLOT/8-131 AC A0A4V3EVB7.1 #=GS A0A1X9H0B3_9CAUD/12-105 AC A0A1X9H0B3.1 #=GS A0A6N2I1R8_9ACTN/16-152 AC A0A6N2I1R8.1 #=GS A0A2H1EG71_9ARCH/6-113 AC A0A2H1EG71.1 #=GS A0A3G3BXL7_9CAUD/10-113 AC A0A3G3BXL7.1 #=GS A0A4R6MU39_9BACL/1-115 AC A0A4R6MU39.1 #=GS A0A5J6TCB9_9CAUD/71-208 AC A0A5J6TCB9.1 #=GS A0A140L9Q4_9FIRM/8-112 AC A0A140L9Q4.1 #=GS A0A0H3KEM5_BURM1/21-149 AC A0A0H3KEM5.1 #=GS A0A0V2F766_CAUVI/26-115 AC A0A0V2F766.1 #=GS A0A5B2VDV6_9RHIZ/12-144 AC A0A5B2VDV6.1 #=GS A0A1D6Z252_9CAUD/10-130 AC A0A1D6Z252.1 #=GS A0A5C6F307_9BACT/7-113 AC A0A5C6F307.1 #=GS A0A653FQK6_9CAUD/9-115 AC A0A653FQK6.1 #=GS A0A5J6TEQ3_9CAUD/40-145 AC A0A5J6TEQ3.1 #=GS A0A127KND5_9CAUD/12-140 AC A0A127KND5.1 #=GS A0A410T4P4_9CAUD/16-136 AC A0A410T4P4.1 #=GS A0A3Q8HYR0_9CAUD/40-154 AC A0A3Q8HYR0.1 #=GS A0A653PV13_9ACTN/15-144 AC A0A653PV13.1 #=GS A0A143HBZ1_9BACL/10-130 AC A0A143HBZ1.1 #=GS A0A3G2KFC4_9CAUD/11-146 AC A0A3G2KFC4.1 #=GS A0A0W8IGC3_9MICC/7-146 AC A0A0W8IGC3.1 #=GS A0A328A704_9STAP/24-144 AC A0A328A704.1 #=GS A0A133ZE86_9ACTN/16-136 AC A0A133ZE86.1 #=GS A0A401ZBH0_9CHLR/24-138 AC A0A401ZBH0.1 #=GS C7JFF8_ACEP3/45-151 AC C7JFF8.1 #=GS A0A0R2A909_9LACO/7-135 AC A0A0R2A909.1 #=GS A0A0Q7T9K6_9CAUL/27-115 AC A0A0Q7T9K6.1 #=GS R4TPD5_9CAUD/39-143 AC R4TPD5.1 #=GS A0A2V1N1V5_9LACO/7-132 AC A0A2V1N1V5.1 #=GS A0A649VMN9_9CAUD/36-166 AC A0A649VMN9.1 #=GS A0A0R1J6A1_9LACO/1-53 AC A0A0R1J6A1.1 #=GS A0A4P8YSL6_9ENTR/9-115 AC A0A4P8YSL6.1 #=GS A0A5Q3LA81_9BACT/5-111 AC A0A5Q3LA81.1 #=GS A0A0R8VCS9_9CAUD/9-156 AC A0A0R8VCS9.1 #=GS A0A2U2C493_9RHOB/9-133 AC A0A2U2C493.1 #=GS A0A0F3GQZ2_9BACT/1-78 AC A0A0F3GQZ2.1 #=GS V9W1L8_9BACL/2-106 AC V9W1L8.1 #=GS A0A1I7ICV1_9BACL/1-96 AC A0A1I7ICV1.1 #=GS A0A1L3ZVB7_9SPHN/8-132 AC A0A1L3ZVB7.1 #=GS A0A4Q2UBR7_9RHIZ/21-116 AC A0A4Q2UBR7.1 #=GS A0A1Y6CP97_9PROT/9-124 AC A0A1Y6CP97.1 #=GS D5CT73_SIDLE/9-137 AC D5CT73.1 #=GS D4MWK7_ANAHA/9-139 AC D4MWK7.1 #=GS A0A1T4WWF5_9CLOT/11-126 AC A0A1T4WWF5.1 #=GS D4ZMR6_ARTPN/159-274 AC D4ZMR6.1 #=GS R5W605_9BACE/9-113 AC R5W605.1 #=GS A0A6P0UKQ6_9FLAO/22-149 AC A0A6P0UKQ6.1 #=GS A0A328TRQ9_9GAMM/9-115 AC A0A328TRQ9.1 #=GS A0A343JEZ3_9CLOT/10-125 AC A0A343JEZ3.1 #=GS A0A6N7ZRC6_9RHOB/37-157 AC A0A6N7ZRC6.1 #=GS W8EF01_9CAUD/25-158 AC W8EF01.1 #=GS A0A4D6A206_9CAUD/7-144 AC A0A4D6A206.1 #=GS A0A0K8P3Z2_IDESA/20-149 AC A0A0K8P3Z2.1 #=GS A0A5C6E5L3_9BACT/1-70 AC A0A5C6E5L3.1 #=GS A0A191KBN7_9CAUD/6-150 AC A0A191KBN7.1 #=GS A0A0F5Y9F7_9CYAN/181-296 AC A0A0F5Y9F7.1 #=GS A0A4V2US76_9BACI/7-111 AC A0A4V2US76.1 #=GS A0A0Q5HQR9_9BURK/7-135 AC A0A0Q5HQR9.1 #=GS A0A514A4U3_9CAUD/23-141 AC A0A514A4U3.1 #=GS A0A1P8BL67_9CAUD/55-173 AC A0A1P8BL67.1 #=GS A0A069DII2_9BACL/57-165 AC A0A069DII2.1 #=GS T0HBM2_9SPHN/2-67 AC T0HBM2.1 #=GS A0A5Q2W8L7_9CAUD/11-147 AC A0A5Q2W8L7.1 #=GS A0A4D6AEM9_9CAUD/10-129 AC A0A4D6AEM9.1 #=GS Q94M90_9CAUD/13-131 AC Q94M90.1 #=GS A0A1H0VS82_9CLOT/10-126 AC A0A1H0VS82.1 #=GS A0A326UBY3_9CHLR/24-138 AC A0A326UBY3.1 #=GS A0A429WSN9_9BURK/7-135 AC A0A429WSN9.1 #=GS A0A0Q5VID4_9CAUL/9-113 AC A0A0Q5VID4.1 #=GS A0A554VRL6_9FLAO/10-145 AC A0A554VRL6.1 #=GS A0A1I3T3M7_9BACL/58-156 AC A0A1I3T3M7.1 #=GS K2FH61_9BACI/7-135 AC K2FH61.1 #=GS A0A0K0MWM1_9CAUD/94-224 AC A0A0K0MWM1.1 #=GS A0A1G8MQ21_9RHOB/7-131 AC A0A1G8MQ21.1 #=GS A6TU92_ALKMQ/7-120 AC A6TU92.1 #=GS A0A097BY81_9CAUD/8-128 AC A0A097BY81.1 #=GS A0A377R4L1_9NEIS/15-148 AC A0A377R4L1.1 #=GS A0A1X9SHF7_9CAUD/73-218 AC A0A1X9SHF7.1 #=GS A0A4P7L7K6_9GAMM/6-118 AC A0A4P7L7K6.1 #=GS A0A1K2A832_9BACL/4-124 AC A0A1K2A832.1 #=GS G7ZG61_AZOL4/19-109 AC G7ZG61.1 #=GS A0A0L0ULX2_9BASI/8-77 AC A0A0L0ULX2.1 #=GS W4LX03_9BACT/14-129 AC W4LX03.1 #=GS A4J1U6_DESRM/6-109 AC A4J1U6.1 #=GS A0A4R6EWU3_9ENTR/9-115 AC A0A4R6EWU3.1 #=GS A0A6M3BDX3_9CAUD/6-136 AC A0A6M3BDX3.1 #=GS A0A4D6BI89_9CAUD/7-129 AC A0A4D6BI89.1 #=GS A0A1H9U1D1_9BACI/6-112 AC A0A1H9U1D1.1 #=GS Q9MC30_9CAUD/9-127 AC Q9MC30.1 #=GS W5WBZ1_9PSEU/14-141 AC W5WBZ1.1 #=GS E8ZE21_9CAUD/6-136 AC E8ZE21.1 #=GS A0A1W1V729_9DEIO/22-137 AC A0A1W1V729.1 #=GS A0A3T0E9F5_9PROT/5-93 AC A0A3T0E9F5.1 #=GS A0A3N4ST37_9ACTN/48-150 AC A0A3N4ST37.1 #=GS Q5HMX2_STAEQ/30-135 AC Q5HMX2.1 #=GS A0A3A9F5Y5_9BACT/9-127 AC A0A3A9F5Y5.1 #=GS A0A4D6A5H8_9CAUD/1-115 AC A0A4D6A5H8.1 #=GS G4L6J6_TETHN/9-116 AC G4L6J6.1 #=GS A0A0U3NTM6_9ACTN/36-128 AC A0A0U3NTM6.1 #=GS L1Q8K9_9CLOT/11-136 AC L1Q8K9.1 #=GS A0EWQ8_9CAUD/12-132 AC A0EWQ8.1 #=GS U2DBQ3_9FIRM/1-72 AC U2DBQ3.1 #=GS A0A514TWU0_9CAUD/22-151 AC A0A514TWU0.1 #=GS A0A037YZP9_CLOTT/10-125 AC A0A037YZP9.1 #=GS A0A5B9NII5_9CAUD/111-221 AC A0A5B9NII5.1 #=GS A0A0H4VTD1_9BORD/4-57 AC A0A0H4VTD1.1 #=GS A0A3G3M530_9CAUD/11-135 AC A0A3G3M530.1 #=GS A0A7C9I2X2_9DEIO/51-166 AC A0A7C9I2X2.1 #=GS A0A4D6ANK6_9CAUD/20-142 AC A0A4D6ANK6.1 #=GS A0A220NRL7_9CAUD/9-115 AC A0A220NRL7.1 #=GS I6T7K9_9CAUD/12-132 AC 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