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Allatostatin Provide feedback
This family consists of allatostatins, bombystatins, helicostatins, cydiastatins and schistostatin from several insect species. Allatostatins (ASTs) of the Tyr/Phe-Xaa-Phe-Gly Leu/Ile-NH2 family are a group of insect neuropeptides that inhibit juvenile hormone biosynthesis by the corpora allata .
Belles X, Graham LA, Bendena WG, Ding QI, Edwards JP, Weaver RJ, Tobe SS; , Peptides 1999;20:11-22.: The molecular evolution of the allatostatin precursor in cockroaches. PUBMED:10098619 EPMC:10098619
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR010276
This family consists of allatostatins, bombystatins, helicostatins, cydiastatins and schistostatin from several insect species. Allatostatins (ASTs) of the Tyr/Phe-Xaa-Phe-Gly Leu/Ile-NH2 family are a group of insect neuropeptides that inhibit juvenile hormone biosynthesis by the corpora allata [PUBMED:10098619].
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
|Molecular function||neuropeptide hormone activity (GO:0005184)|
- the number of sequences which exhibit this architecture
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This example describes an architecture with one
Gladomain, followed by two consecutive
EGFdomains, and finally a single
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Allatostatins are pleiotropic neuropeptides. In some insects they are known to inhibit the synthesis of juvenile hormone, an important regulator of development and reproduction. The full role of allatostatins in hormone production is still unclear .
The clan contains the following 2 members:Allatostatin Carcinustatin
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Curation and family details
|Seed source:||Pfam-B_4313 (release 9.0)|
|Number in seed:||21|
|Number in full:||453|
|Average length of the domain:||11.20 aa|
|Average identity of full alignment:||60 %|
|Average coverage of the sequence by the domain:||36.41 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||7|
|Download:||download the raw HMM for this family|
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