# STOCKHOLM 1.0 #=GF ID HutD #=GF AC PF05962.10 #=GF DE HutD #=GF AU Moxon SJ, Rainey P #=GF GA 25.0 25.0 #=GF NC 21.5 21.2 #=GF TC 25.6 25.1 #=GF PI DUF886; #=GF SE Pfam-B_5160 (release 9.0) #=GF BM hmmbuild HMM.ann SEED.ann #=GF SM hmmsearch -Z 26740544 -E 1000 --cpu 4 HMM pfamseq #=GF TP Family #=GF RN [1] #=GF RM 17717196 #=GF RT Genetic analysis of the histidine utilization (hut) genes in #=GF RT Pseudomonas fluorescens SBW25. #=GF RA Zhang XX, Rainey PB; #=GF RL Genetics. 2007;176:2165-2176. #=GF DR INTERPRO; IPR010282; #=GF CC HutD from Pseudomonas fluorescens SBW25 is a component of the #=GF CC histidine uptake and utilisation operon. HutD is operonic with #=GF CC the well characterised repressor protein HutC. Genetic analysis #=GF CC using transcriptional fusions (lacZ) and deletion mutants shows #=GF CC that hutD is necessary to maintain fitness in environments #=GF CC replete with histidine. Evidence outlined by Zhang & Rainey #=GF CC (2007) suggests that HutD functions as a governor that sets an #=GF CC upper bound on the level of hut operon transcription [1]. The #=GF CC mechanistic basis is unknown, but in silico molecular docking #=GF CC studies based on the crystal structure of PA5104 (HutD from #=GF CC Pseudomonas aeruginosa) show that urocanate (the first breakdown #=GF CC product of histidine) docks with the active site of HutD. #=GF SQ 61 Q92MC2.1/13-184 SEYRHMP...WKNGGGETVEI.AV..........SPDR..AT..IA...D..FDWRISMATVATN..GAFSIFPGIDRTLSIL.........EGS...G........MTLAIE.GRQ..............PKLLTTSDTPLTFPADVPTSATLV.DGPVT.DLNVMTRRQALKH........RVRRIHVEGSQP........V..-.....TT..SARDL.........VLF.CHRGS--VALVTE...GV...SATLHGLDAAVLVQPG...TLTLSAD------ I7ZG97.1/14-190 KSYARMP...WKNGGGETREI.AI..........FPSA..AS..LD...T..LEWRVSMAVVAQD..GPFSSFPGIDRTLCVL.........EGA...G........MELDFGsGGG..............IKTVTPTSAPFEFAADRPLQARLL.DGAIT.DLNVMSRRERYRH........SVRRLPLEPRPI........S..V.....GS..MANWT.........LLF.CEQGNVRCRLAND...-P...EIALDTWDCLLLSQTT...-ALFELRSDA--- I3TPU8.1/11-174 -GHRRMP...WKNGGGETVEI.AI..........SPAD..AG..LD...G..FDWRLSMATVATD..GPFSIFPGIDRSLAVI.........RGA...G........MELSVA.GVG..............SCSLDPAAEPFAFPADQPTTARLI.DGPIT.DLNLMTRRAGFVH........EMERMRVA-GPV........D..L.....AV..VSEIV.........LLL.CVSGQVGVQIR--...GE...TVDLAPLDALLIDRRG...------------- A0A0F3IVL5.1/12-181 HEYRRMP...WKNGGGETTEI.AV..........FPPE..AD..LA...G..FGWRVSMATVASD..GPFSVFDGIDRTLLIL.........DGP...G........MALTIA.EEP..............PVVLTQTSDPLAFPADAPTSARLV.GGPIL.DLNVMTRRGQWHH........RVIRQRVQGRIA........V..S.....P-..GNASH.........LLL.LARGDLRIGYG--...AG...ECQLTPLDCAVIAGDV...QIETD-------- A8U083.1/9-184 ADHRTMP...WKNGGGSTTEI.AA..........APDG..AG..ID...A..FDWRVSMAVVAAD..GPFSEFPGIDRTLSIL.........DGS...G........LILKGL.DQG..............PVRLERTTEPFGFPADAAVSAALI.DGPIT.DLNVMVRRGRFHD........RTRRLSASRSVS........A..R.....--..CQATV.........ALL.LAETPCRVAIG--...SD...AVDLGHRDALRLDRPD...GVTLTLSSDGSL- Q9HU79.1/11-181 -DYPRMP...WKNGAGSTEEI.AR..........-DGG..DG..LD...G..FGWRLSIADVGES..GGFSGFAGYQRIISVL.........EGG...G........MRLRVD.G-A..............ESAPLRARQAFAFSGDSEVHCTLL.DGAIR.DFNLIYAPRRHRA........RLQWLRVEGELD........W..H.....-G..TASTL.........LLF.AQQDGVAISLQGQ...-P...RGQLAAHDCLCAEGLQglqHWRLT-------- K2JMI3.1/7-179 ADRSPMP...WKNGQGTTTEI.AA..........APAG..AG..LE...D..FDWRLSIARMEAD..APFSAFPGILRTLSVI.........EGS...G........LTLAVE.GER..............PVTLDQDSAPHRFAADRPAEGRLL.DGPVS.NLNIMTRRTSCTH........MMRRVRFQGELQ........V..S.....VT..G--TL.........LVL.CHTGGIGI-----...-G...GASLGPLDCALIEDTE...KAALHCSAASTVF A0A0K1PTX2.1/7-153 TDYRRMP...WKNGGGTTTEI.AI..........EPKE..AG..LAg.eR..FLWRVSIADVASD..GPFSRFEGYDRHIMLL.........EGA...G........MTLDAG.A-H..............GRFTLAPLVPQTFSGDWDVTGTLT.AGAVR.DFNLMVDRARASS........TLEVVHIEQPMQ........L..S.....VA..NEETC.........IAH.ILEGRLSE--A--...--...----------------...------------- A0A0M2WL57.1/10-176 --LRAAP...WKNGGGSTTEI.AI..........APPG..AG..FD...D..FDWRISLATITAS..GPFSSFPGIDRSLMLV.........DGD...S........VQLTLD.GAR..............KVTLSAAQPMLWFPGEAAVFAQ-V.KGPTT.DFNVMTRRDRCRH........QLEKITAPGKLA........R..R.....--..SAATL.........LFV.AGEG--HVLARGG...EQ...QFALARHDALLLDADD...APDWRL------- Q8P734.1/5-181 TEYRRER...WRNQLGWTREI.LR..........LG--..EP..DD...A..WALRLSIAEIEQD..AAFSAFPGIDRELVLL.........RGN...G........MQLQFG.DGR..............QHSLLPPYQRLRFAGEEAVTAVLG.DGPTQ.DFNLMWRRAVLQT........ELLHRPLVGTML........F..F.....AD..PGSAW.........AIH.LLAGQASFGR--D...SG...LPPLLAGDTAWLSART...RSRFVLDGGGELL A1K9W8.1/14-178 --IAPQP...WRNGGGATREI.LC..........AP-S..AD..GE...G..WDWRVSVAEIEQP..GAFSVFAGVDRTALLL.........DGA...G........LALHGSaPQP..............PLVFAAAGCVHRFAGETALAARLG.GGPAR.LFNVMTRRSRASA........VLGTHTG-DGAL........D..L.....GD..AA-AT.........VLF.VTRGRFALTLDAA...-A...GYRLQAGHGLCLDGDS...AQ----------- A0A145VQ31.1/14-191 -RYRRMP...WRNGRGMTTEL.AR..........EP-E..DG..MG...N..FLWRISISEVSRQ..GPFSLFPGYDRLVAVI.........EGE...G........MDLLLD.GSL..............VERLSCKTEPYTFSGDRLAECRLI.GGMIQ.DFNLIVDRHYGRA........TLHRIRKGPSLT........V..G.....GV..G-AIV.........LVY.AVSGEAWIRFREQd.eEQ...RIRLEEEHTLILEGDQ..vEITCPAAEAE--- A0A0S2JBS7.1/9-173 -EFKTIP...WKNGLGHTTEL.AI..........SD-G..GN..LD...D..FAWRLSIASVVND..GDFSNFSGYQRNLVLI.........EGA...G........LTLDHR.NGD..............VDKLIQLLDIARFDGANKTHGSLL.NGGIK.DFNIMTKQTAFSA........EVNCYSERQNVT........L..A.....LL..ADSLL.........FAY.SLTDTMMVN-TAE...GK...DCTVPVGHLVKLQAKN...------------- P76214.2/5-175 -DMRKMSvnlWRNAAGETREI.CT..........FP--..PA..KR...D..FYWRASIASIAAN..GEFSLFPGMERIVTLL.........EGG...E........MLLESA.D-R..............FNHTLKPFQPFAFAADQVVKAKLT.AGQMSmDFNIMTRLDVCKA........KVRIAER----T........F..T.....TF..GSRGG.........VVF.VINGAWQL-----...-G...DKLLTTDQGACWFDGR...HTLRLLQPQGKLL Q6MKV0.1/20-186 STYQRMP...WKNGLGVTDQIdLA..........LSEI..KS..SQ...P..YSWRLSSALVTAS..NPFSIFEGYHRLLSVV.........QGD...G........LVLNQR.---..............---PLLPFQVCEFSGDDHTDCQLI.GSAVR.DLGLIFNPKTHQA........RMQFHSLPAMSE........T..V.....LS.lPEETQ.........FFY.LAKGRMRI-----...-A...DQTAAAQDCFKLTHET...QVKIQNTES---- A0A0D2VNP0.1/9-170 SDYRTMP...WKNGLGTTTEL.AV..........SPAG..AS..ID...S..FVWRISAAQVGAA..GPFSSFLGVARTLLQT.........SGT...P........MTITCTaKDEdasl......prtiWNHTMQWLQPITFHGEEQVGCTRL.DGVAT.DFNVMTRRAQCQS........TTSVLELISGGY........F..S.....RVvpGATTC.........FVH.ALSGEIAVQVVSC...S-...----------------...------------- X6N074.1/20-193 KDYVSMP...WKNKQGITKEV.MK..........YPAD..SN..IG...N..FEWRISIATCSTS..SEFSKFLNCKRVIIQL.........EGE...P........MVLMHS.TGSden........ksqSAHECKLYEPYIFDGDINTSSKIS.N-TVT.DFNVITNNTKFDS........KVEVISVLGKKS........I..T.....LD..GQYN-.........FVF.VAKE-PPIQLN--...-D...KQTLKKYDSVYSPGSI...--SLDLQN----- A0A0R2Q709.1/7-168 NEHVAMP...WANGRGTSYEI.AS..........--DR..NS..SD...E..WSWRLAMAPVNED..GPFSRIDCVNRSLVVV.........EGA...G........MVLSVD.R--..............KKLQCHPLQVVQFRGEAITEAALI.DGPIT.DINLMVRRKDATG........AMHIVHQ---AG........A..L.....--..-ASTS.........IIV.AVNGPARVQCD--...ET...LVMLERHDALLECDSH...--SLALES----- R1BZV1.1/11-186 SEFAEQR...WANGLGVTREI.AVdrt....pdaAHHA..QN..AA...P..FRWRLSMADLAAP.gGPFSMLHGIDRSLTLL.........EGT...G........VTLAVD.G-A..............APVALEINSPFAFPGDVKTDCNVG.SATGR.DLNAMWDRSRCTA........SVNVVTAPTAVD........F..P.....VE..SAVAF.........AVA.LADE-ASLAISGNd.sGAdciPTLLAKEDAMRMDV--...------------- L8XXU0.1/9-167 --LTVKP...WKNGLGTTREV.MI..........HPQN..AT..MD...D..FIWRVSMASVEHT..GPFSHFPHCQRSLALL.........TGQ...S........IELLID.G-A..............HHTLKKSGHPITFSGESTTKMIHC.AEPAL.DCGIITDTRRARH........SMVRVDF--TET........D..Y.....QR..SSLTT.........CII.ALTT-CTV-----...-N...EQALEPLDALFFSEHD...ERH---------- T0S7S0.1/11-172 -DVAPTP...WKNGGGETRQL.VA..........WP--..QG..AD...D..WTLRVSIADVTQD..GPFSSFDGIRRWFTVL.........SGD...G........VRLFED.M--..............--DICVGDKLYEFDGALAPACSLL.GSAVR.DFNVMYREADG-G........SMVVTNAKATHS........L..Y.....AM..GARFL.........GLF.TVDGGELMING--...LE...SVRVSPMTLVWAQDTS...-AELV-------- A0A0R2Q708.1/10-166 -DRTPQP...WKNGLGVQYEI.MC..........--DG..SL..PD...D..WTWRLSTADITQD..VPFSVFPGVNREFCVA.........DGN...G........VVLTIN.G--..............VEHRCEPGSITKFRGDDEVHATLI.DGPMK.ALNLMVRDGAGEK........HLHLVRAGDSIG........L..-.....--..N-SQC.........VLV.SIIEQAI--LDMS...TG...EVALDRLDAVLFFDHG...------------- S6HUK6.1/13-188 -HYKLSK...WKNGRGDTLEL.AS..........DSEL..AK..NG...A..FDWRLSIATLSGD..SQYSCFNGIDRSQILL.........QGE...R........VVLSIG.NAEt............aNQIKLNRYDKAVFSGAEQVSCQLL.GCTIAkMFNLMTAAHSYSH........LLSIHQLSAQMP........I..V.....T-..ACDTL.........LIF.SVSDALQVQVS--...GR...ETALQWHEMLRIEQPA...LQAIALDNR---- A0A126YVB3.1/8-183 ADLTPAP...WANGLGSTTEI.ARgigsgrldsgG-AD..RG..GA...D..WDWRISVATIEAA..TPFSALPGVDRVLMAL.........GPD...P........LTLMVE.G--..............KQHDLQPQETLQFSGEDDVRPVGV.DTPGR.DVNLMTRRGAFHG........SLHLTRIRNGLT........V..G.....ST..PGTRV.........ALI.LLEGAGVVAQEGE..tAP...TLQLGPLGTLLGDPGE...------------- A0A0U3MIM5.1/32-190 DDVTPVP...WRNGGGKTREL.LA..........WP--..-T..VA...D..WKLRISVADIDRD..GPFSAFPGVDRWFGVL.........SGA...G........VELLGS.Q--..............---RRPGDGLLQFAGEDAPDCRLI.QGPTR.DFNAMHRRGAGRF........RVQPAERP----........V..I.....PH..EVDWF.........GLF.TERGGLLIH---G...AR...AVPVAPHTLAWCEAPA...AQSCVF------- A0A0K1PGV1.1/4-155 -------...-----------.--..........----..--..QG...D..WLLRLSIAEIEQD..AAFSAFPGIERELVLL.........HGA...G........LRLRFT.DGR..............CVTLLPPYQRLRFAGEDELTGAPV.DGTSR.DFNLMWRRADLHA........ELLHRSLAGSMT........F..G.....SE..PQVAW.........AIY.LLTGQIAFE---D...AA...MPAMQAGDTAWLGACE...HRRHLLHGSGELL F6CYE5.1/14-159 ADYPIVP...WKNGLGHTRNI.AR..........LSDE..QG..LQ...-..--YRISQASVVEN..GLFSDFSGLHRILILL.........SGH...G........LAMTHQ.NEQg...........mqHIRLTKVLEMAQFSGGDQTFASLT.DGPIE.DLNVMVREADTKA........QVIARQAPTELA........F..D.....PI..QSNALl.......hAIY.CAEEC-EL-----...--...----------------...------------- C8XB50.1/12-135 QDVPDSP...WRNGRGRTREI.RR..........GD--..--..--...-..-GWRLSIATIAAA..GEFSRFPEIDRIFVVA.........RGE...-........LELTVG.G--..............VTDRLTAGQVRSFAGEVPVTAAPL.AGPVV.AVNVMTDRGRGRA........DVSVDRI-CGAV........P..P.....A-..A----.........AMV.VLTG---------...--...----------------...------------- R6H2B3.1/9-149 QDFQTSH...W--AGGVTTQL.AI..........GPQG..TH..YAd.rD..FLWRISSAQVELD.hSVFTHLPDYHRFLTVL.........EGE...-........LELQIG.S-G..............PKLPLPPLSLCQFDGGVPVESW--.-GRCK.DLNLMLRKGACTG........SMEVLRLPAGSS........V..L.....PP..DWDIL.........GLY.CVQGGTSW-----...--...----------------...------------- L8GSG2.1/22-184 SDYKSMA...WKNGLGQSVEL.AV..........VPPG..CD..FTv.tP..FMWRVSLTEVVGS..TTFSLFHSYDRILLRV.........EGE..eD........VRLKHN.FAA..............KVETFPPFTPHKFKGEWHTECLVTsHQKVV.DMNVIFERQQVKA........SVKALEAIEGVP........I..H.....HTitSKGTT.........LVY.SYNGTVDITSAD-...--...LSDAAGGD--------...------------- J0WR75.1/11-191 -DFVVSE...W--SGGKTTQI.II..........EPPG..AL..YAd.rD..FHFRLSSATVELE.eSDFTSLPDYDRIIAPV.........EGE...-........LSLTYN.GSE..............TPVILRELECAAFDGAWETRSR--.-GRVV.DYNLMTRKGVCRG........NAFALIVGAGQT........A..EircesGE.qGRSVL.........LCW.CVQGSAEL--SAG...GE...TTALSSRDAARLEVAPggaAVNVKVQNQG--- H1HTM8.1/9-164 KDYRVSR...W--SGGETREF.LL..........FPDG..AS..YAg.rD..FLWRVSSATVELA.eSDFTPLPDYRRFLTPL.........SGA...-........LRLSQN.GGA..............-FRALGALEVLEFDGGAETKSR--.-GEVT.DFNLMLRKGEATG........GMTTAVLGAGEScrladlfpA..E.....AA..ESDAL.........LLY.CYAGAAALRRAEK...EW...----------------...------------- A1ZVU1.1/10-181 -SFHETQ...W--AGGTTTEF.FI..........YPRT..AV..YNq.lN..FSFRLSAATVQAE.tSEFTSLPDVSRTLMVL.........DGT...-........MTLTHE.G-Q..............HTSQLNKFDTDVFEGGWKTTST--.-GQCT.DFNLMTM-GDAQG........TLEGWAIDKSQI........IdyP.....LK..TSSSW........fFMY.VYVGKVSIYIN--...NE...KHTVNQGDVLVLETPS...LISLQVKGR---- R6APX1.1/27-185 --MPVSL...W--SGGRTTEI.YI..........APEG..AL..YAe.rN..FLFRISTAEVELE.eSDFTSLPDYNRLIASV.........SGT...-........MRLSHGaNGS..............EKLVLPRSTVYAFDGGIQTHCV--.-GKAR.DLNLMLRKGAAEG........ELVFVDSGTELD........L..E.....PA..ANETM.........LLFeLESGNAALCAGGN...AR...LRCTANGQCA------...------------- T0N0W1.1/13-181 --QTTTT...W--SGGTTTEL.AI..........YPKD..AI..YSq.rN..FKWRLSSAVVNDE.kSTFTSLKGIWRLIMVL.........DGE...-........LTLEHK.G-K..............HTVHLKPFEQDSFSGEWITNST--.-GKVK.DFNLMMASGCE-GninviklrKYRVFEIKEELS........G..S.....NN..EAKKLt.......eAFY.CVKGNALVNID--...AR...EIELNEGDFLFINLEN...------------- F4XEK1.1/9-177 EDYVTTN...W--SGGTTTQL.AI..........APQE..SV..YAn.rD..FLWRFSSAKVILE.hSDFTPLPDYNRLIATV.........KGG...-........LDMKVG.DGA..............RF-SLAPYQIYSFDGAVSVESW--.-GCCT.DFNLMLRKGQCQG........TLQALTLSAGSA........V..S.....WT..APVSApepfprrtlAVY.CGQGQVSLP----...ED...HKTASAGQFLLCREAE...------------- A0A117SLA0.1/14-180 ---STST...W--SGGTTTQL.AI..........YPKT..SD..YKa.rN..FMWRLSSARVDAD.eSTFTSMPEIWRHIMII.........DGE...-........MRLLHE.G-H..............HSVLLRPFEQDSFSGGWATKSI--.-GRAR.DFNLMLGQGC-KG........ELEAMFIGKEMK........M..E.....TA..ARPAAidfa.nrtdGFY.CPTGSINVVIN-E...GK...TYILNEGDLMLLNSLQ...------------- F4Q2M2.1/11-102 --YNLVV...WKNGKGKSTQI.HV..........EPQG..MS..VQ...D.pFEWRVSSAVIQQV..GPFSAFEGYTRTLILL.........KGT...K........IALFHQqQPN..............ICVQLNYFRPYTFNGGWDTDS---.-----.-------------........------------........-..-.....--..-----.........---.-------------...--...----------------...------------- A0A073J2L5.1/11-172 --LDHKR...W--SGGITTQL.AI..........WPEE..AD..YAs.rR..FDWRISSAAVEDE.rSTFTPLPGVHRHIMTL.........GGE...-........MTLTHE.GIR..............TRVLKPLSDVEEFEGEWRTTSV--.-GRCT.DFNLMLHAG-FRG........RIAPLHAADVTT........L..P.....SA..PSEVVw......ygIYF.AADAKAAIRYDGY...RV...ELSQERGDFVLIS---...------------- A0A0B7NQJ2.1/34-223 TDYHSQL...WKNGLGTTDEI.AI..........YPPD..KDfiKD...D..FFWRFSTNTMHAN..CNFSVFPGYECTTVIL.........PTD...EeqakskayFSLSHQ.GGE..............SFTKIQPLFPYSWHGEWATTCKLT.NSPVE.CLQFMLRRESGKA........QVRIEKIGSFET........D..L.....QG..DVDSGknmlfgafaLVY.VVEGFISVILDENhahSQ...KFELKKGETLFVERDE...------------- R6CBR6.1/8-151 -EYAVSE...W--AGGKTTQL.YI..........YPQG..NE..YAk.rN..FLLRISSATVECE.rSEFTSLPQVERIILPL.........SGS...-........LHLFYE.G-H..............GEKKLEPFEQDRFDGGWKTVSV--.-GRAT.DFNVMLREGT-QA........QVRLLDVNPNEQ........A..S.....VE.vAANGL........tAVF.AAQGTAVVDGK--...--...----------------...------------- A0A090HWT1.1/9-172 --FKSSE...W--AGGETDEI.II..........FPEE..AD..FK...DrtFDYRISSATCNLD.sSKFSPYDGYRRFITPL.........DNE...-........LILKNG.Q--..............KDLTLKPFEIYEFSGSDDVSSY--.-SKVR.DFNLILKE-TLEG........ELFTEEIE-GEL........H..L.....KN..DVKTL.........IAF.NYDGDLDV-----...-E...DKKLDFMSAVVLEEGE...--EAIIKGTGKLL Q8RI56.1/11-158 ---KVSV...W--AGGTTNEI.FI..........YPEN..SS..YA...DriFKARISVATTNNGekSLFTSLPGVERYISKL.........SGD...-........MKLQHT.D-H..............YDVEMEDYQIDRFRGDWETYSW--.-GKFR.DFNLMLKGIRGDL........YYRQIRSK-CRL........H..L.....EK..DSTVV.........FLY.VIDGKINVN----...--...GTDLETEDF-------...------------- Q54RW2.1/10-103 -DYDHMV...WRNGKGKSTQI.HI..........EPIG..ST..LN...D.sFTYRISRAVVGTA..GPFSTFDGYNRSLLIL.........KGN...R........LSLFHRqKPN..............ESIDLDYFKPYNFNGGYETDSV--.-----.-------------........------------........-..-.....--..-----.........---.-------------...--...----------------...------------- F2ICB2.1/9-148 --FKVAK...W--AGGVTTEL.FI..........FPEN..AS..VTa.rD..FDWRISSAVVEEE.eSDFSLFEGYERILIPL.........TGD...L........EMIHQIpTGE..............LIQKVSKFELARFDGNWQTKGK--.-GKLT.DFNFIFK-SKFNP........KVELIFGK-KNL........P..L.....EI..KISPI.........AFY.LYEGSIQL-----...--...----------------...------------- R6FKP0.1/16-182 ------R...W--AGGRTRQL.AI..........YPQD..AQ..GAeafD..FVFEITSSTTDIK.eSEYTIYESYNRTLMII.........SGE..sA........LTLEDG.---..............DSHSLSPYEQCTFDGALKV---LS.RGRAV.DYEMTLRKGRS-G........RVEFLGRVSDLS........I..K.....ED..P-GYL.........GLY.CLKGSLRIYSK--...DG...EHLLYEGDQFSAFSDE...TKELRLEGEALV- A0A0L0H9X2.1/60-189 KDYIRMP...WKNGLGETHQI.AI..........SPPS..TD..FEt.eE..FVWRLALSEVRDS..CSFSVFPGYDIALFLL.........PDA...H........PTVAHT.RRNsltnrvalhhndqaTPVPLRPLIPYTYSGEWPTTCRIR.SGPIR.HLTFIANRDRAHV........T-----------........-..-.....--..-----.........---.-------------...--...----------------...------------- J1H391.1/10-169 --QKTTK...W--SGGETSEL.FI..........YPPQ..AS..LTa.qD..FLFRISTASVACG.aSDFTLFPQKQRILLLL.........EGD...-........ITLTFR.G-G..............ESIRLTPMQSAAFSGTWHT---LS.RGTGV.NFNLIFSPSA-KG........FLKAIKLRPEKA........W..Q.....FS.pQSRFT.........GLY.FPSGLAHVMAG--...DS...SYSIEKNDFLLISNPA...------------- A0A0L8EYS4.1/11-176 EEYSVSK...W--SGGQTTEL.YI..........YPED..SK..YKd.rN..FMWRISSATMDVQ.eSTFTYLPGFSRELMVI.........HGE...-........TTLEHE.S-R..............YKVTLKPFEKDSFMGDWTTKGF--.-GKAS.DFNLMTSQD-CNG........SLDVLDVKDKIS........I..E.....LN.cTENGFnv.....sqYFY.PVGGSIEVQI--K...DD...KFHVDERDLFVISYSD...------------- E3PST6.1/11-179 EEYQTSY...W--SGGTTTQM.LI..........FPEH..SS..YAv.rN..FAFRISSATVDLD.kSEFTELKGINRYITPL.........D-N...L........LRLTHN.N-K..............DFIDLQPFEVYNFSGGIPTTSY--.-GKAK.DFNLMLSEKA-SG........NLESAKIDKVST........I..T.....LF..K-DTLevafenrfeI--.LISPFHDLNIKLE...DK...DIILSKMDLLLVNANK...------------- R6VK43.1/11-179 EEFSTSN...W--SGGTTTQL.YI..........YPED..GN..YAe.rN..FQARISSATVDVV.kSEFTSLPNVKRYLMIF.........EGH...-........LDLIHG.-VN..............TRVELEPYQVDEFDGGIPTVS---.YGKVV.DFNLMLKDGAD-G........VMETAQLKTAQQ........A..V.....IE..REKDYn......llCIY.VKEGSMKI-----...-A...NQKVSAGELAVIEDWE...-HPVELKNEA--- R6EQW9.1/17-189 -------...---MGGTAREL.AV..........FPAT..AE..YLn.rD..FIWRISVDSIESE.eSDFSRLPDYGRVLLIL.........EGE...-........TVLSYE.G-Q..............RVARLAPLEQDRFDGSWKTRSF--.-GKIR.GFNLMVRKGC-DG........FVDVIFPKEESS........P..QsapisGS.rSNTTH.........ALF.CEDGYCLITKG--...TD...SIMVREGQLLTLEFEEg.eKAEYSVMGEGTV- F4PCT1.1/75-208 ESYVHLP...WKNGLGETAEI.AV..........YPPN..RN..FR..kD.pFMWRLSLSEVRDS..CSFSLFPGYDIALFLLpesganapiRGNlsaP........AVLYHN.DQA..............TPVPIKPLVPYTYKGEWPTTCSVN.ASPLK.HLTFTSNRRVAKV........SMSLETI-----........-..-.....--..-----.........---.-------------...--...----------------...------------- D2RNL6.1/10-130 -QAVTTR...W--SGGTTTEF.YI..........DPPG..SA..YAr.rD..FLIRISSATVDLE.aSDFTLLPDYNRIILPL.........RGG...-........FTLTFPeDGN..............RQVTLGPLEQASFDGAWHTHSV--.-GKAV.DFNVMVRKGHTGT........-CEKVTG-SRLL........Q..-.....--..-----.........---.-------------...--...----------------...------------- R1B3A8.1/3-122 -------...-----------.--..........----..--..--...-..-------------..------HGIDRSLTLL.........EGT...G........VTLAVD.G-A..............APVALEINSPFAFPGDVKTDCNVG.SATGR.DLNAMWDRSRCTA........SVNVVTAPTAVD........F..P.....VE..SAVAF.........AVA.LADE-ASLAISGNd.sGAdciPTLLAKEDAMRMD---...------------- A0A0B7MX38.1/29-213 QDYQTQC...WKNGLGRTSEI.SI..........YPPE..KD..YRk.dS..FFWRLSKNEIDAN..FNFPIMLGYECTNIILp......seHGTk.sT........IHLNHR.GEE..............ASTTVKPLFPYSWNAEWATSCKVT.NAPVS.SLQFLIKRDLGTA........QFSVDKIGQPVS........N..E.....SGetGRK-Lilg...afaLVY.VLDGHVRIGLDENspqRQ...SRFLSAGQALYVERDA...------------- A0A095XCH0.1/9-177 -EYNETS...W--SGGKTREY.FI..........YPVD..ST..YKd.rD..FKIRFSEASVDIT.gTDFTKLPGYKRYLIPI.........T-N...T........LVLNMK.G--..............NKIPIKKYTAFYFDGNDDIVSE--.-STGH.DLNLMLSEDLV-G........KLEVVKFYHELL........I..K.....DD.iKKSKI........lFFY.SLEDGVQI--ISK...KK...SVTLDKNDVAVFISDD...KFELKISA----- J5U5F7.1/13-151 ----ENQ...W--SGGTTTQL.VI..........FPEG..SN..LAd.rD..FDFRISSATFTST.sSNFSEFNSYQRYLLPL.........IGK...-........LSVNHE.N-L..............YSRKLDTYELEYFLGSWKTSST-N.TLDCK.DFNLIVKKG-IQS........NLSVLSE--GMS........Y..I.....PK..KNGKL.........FLY.SLGS-FELAIAT-...--...----------------...------------- D2VRV3.1/18-60 SDYQTMP...WKNGQGTTRQF.II..........SPSTctSV..ND...D..FTFRLSSAQMKT-..----------------.........---...-........------.---..............------------------------.-----.-------------........------------........-..-.....--..-----.........---.-------------...--...----------------...------------- T0DTU1.1/4-137 -------...-----------.--..........----..--..--...-..-----SCSTIEID.kSKFTKLPNIQRKLMLL.........DGN...-........LILKHE.N-C..............EEVNLDKFDIHTFSGELDTIS---.YGKGI.DFNLMTTNNCI-G........ELEHIYIKSKT-........Q..I.....KL..NEDYVdkkykykfiCIY.SLNNSFNIEIQNK...-R...SLEIQNGEVVIIKI--...------------- A0A0D2VZN5.1/77-134 -------...-----------.--..........----..--..--...-..-------------..----------------.........---...-........------.---..............----------------------CL.DGGAI.DFNVMTRRAQCQS........TTSVLELISGGY........F..S.....RVvpGATTC.........FVH.ALSGEIAVQVVS-...--...----------------...------------- //