Summary: PIF1-like helicase
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PIF1-like helicase Provide feedback
This family includes homologues of the PIF1 helicase, which inhibits telomerase activity and is cell cycle regulated . This family includes a large number of largely uncharacterised plant proteins. This family includes a P-loop motif that is involved in nucleotide binding.
Zhang DH, Zhou B, Huang Y, Xu LX, Zhou JQ; , Nucleic Acids Res. 2006;34:1393-1404.: The human Pif1 helicase, a potential Escherichia coli RecD homologue, inhibits telomerase activity. PUBMED:16522649 EPMC:16522649
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR010285
This entry includes a group of DNA helicases, including Pif1 and Rrm3 from budding yeasts and Pfh1 from fusion yeast. This entry also includes Pif1 like proteins from prokaryotes and eukaryotes including plants.
Pif1 is a DNA helicase conserved from bacteria to humans [PUBMED:17172855, PUBMED:16522649]. It suppresses both G-quadruplex-associated DNA damage and telomere lengthening. In budding yeast, it exists in two forms, nuclear form and mitochondrial form. Its nuclear form inhibits telomerase, while its mitochondrial form is involved in repair and recombination of mitochondrial DNA [PUBMED:10926538, PUBMED:10693764].
In budding yeasts, another DNA replicative helicase, Rrm3 is recruited to paused replisomes to promote fork progression throughout nonhistone protein-DNA complexes, naturally occurring impediments that are encountered in each S phase where replication forks pauses [PUBMED:10693764]. It shares protein sequence similarities with another DNA helicase, Pif1. However, their functions are different. Rrm3 promotes telomere replication, while Pif1 inhibits telomere replication [PUBMED:10693764]. They also have opposite effects on replication fork progression in ribosomal DNA [PUBMED:10693764].
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
|Molecular function||DNA helicase activity (GO:0003678)|
|Biological process||DNA repair (GO:0006281)|
|telomere maintenance (GO:0000723)|
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AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes .
The clan contains the following 198 members:6PF2K AAA AAA-ATPase_like AAA_10 AAA_11 AAA_12 AAA_13 AAA_14 AAA_15 AAA_16 AAA_17 AAA_18 AAA_19 AAA_2 AAA_21 AAA_22 AAA_23 AAA_24 AAA_25 AAA_26 AAA_27 AAA_28 AAA_29 AAA_3 AAA_30 AAA_31 AAA_32 AAA_33 AAA_34 AAA_35 AAA_5 AAA_6 AAA_7 AAA_8 AAA_PrkA ABC_ATPase ABC_tran Adeno_IVa2 Adenylsucc_synt ADK AFG1_ATPase AIG1 APS_kinase Arch_ATPase Arf ArgK ArsA_ATPase ATP-synt_ab ATP_bind_1 ATP_bind_2 Bac_DnaA CbiA CBP_BcsQ CDC73_C CLP1_P CMS1 CoaE CobA_CobO_BtuR CobU cobW CPT CTP_synth_N Cytidylate_kin Cytidylate_kin2 DAP3 DEAD DEAD_2 DLIC DNA_pack_C DNA_pack_N DNA_pol3_delta DNA_pol3_delta2 DnaB_C dNK DUF1611 DUF2075 DUF2478 DUF258 DUF2791 DUF2813 DUF3584 DUF463 DUF815 DUF853 DUF87 DUF927 Dynamin_N ERCC3_RAD25_C Exonuc_V_gamma FeoB_N Fer4_NifH Flavi_DEAD FTHFS FtsK_SpoIIIE G-alpha Gal-3-0_sulfotr GBP GTP_EFTU Gtr1_RagA Guanylate_kin GvpD HDA2-3 Helicase_C Helicase_C_2 Helicase_C_4 Helicase_RecD Herpes_Helicase Herpes_ori_bp Herpes_TK IIGP IPPT IPT IstB_IS21 KaiC KAP_NTPase KdpD Kinesin Kinesin-relat_1 Kinesin-related KTI12 Lon_2 LpxK MCM MEDS Mg_chelatase Microtub_bd MipZ MMR_HSR1 MobB MukB MutS_V Myosin_head NACHT NB-ARC NOG1 NTPase_1 NTPase_P4 ParA Parvo_NS1 PAXNEB PduV-EutP PhoH PIF1 Podovirus_Gp16 Polyoma_lg_T_C Pox_A32 PPK2 PPV_E1_C PRK Rad17 Rad51 Ras RecA ResIII RHD3 RHSP RNA12 RNA_helicase Roc RuvB_N SbcCD_C SecA_DEAD Septin Sigma54_activ_2 Sigma54_activat SKI SMC_N SNF2_N Spore_IV_A SRP54 SRPRB Sulfotransfer_1 Sulfotransfer_2 Sulfotransfer_3 Sulphotransf T2SSE T4SS-DNA_transf Terminase_1 Terminase_3 Terminase_6 Terminase_GpA Thymidylate_kin TIP49 TK TniB Torsin TraG-D_C tRNA_lig_kinase TrwB_AAD_bind TsaE UvrD-helicase UvrD_C UvrD_C_2 Viral_helicase1 VirC1 VirE Zeta_toxin Zot
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Curation and family details
|Seed source:||Pfam-B_4988 (release 9.0)|
|Number in seed:||13|
|Number in full:||6127|
|Average length of the domain:||190.20 aa|
|Average identity of full alignment:||20 %|
|Average coverage of the sequence by the domain:||33.73 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 80369284 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||10|
|Download:||download the raw HMM for this family|
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