Summary: Ion channel regulatory protein UNC-93
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Ion channel regulatory protein UNC-93 Provide feedback
This family of proteins is a component of a multi-subunit protein complex which is involved in the coordination of muscle contraction. UNC-93 is most likely an ion channel regulatory protein .
de la Cruz IP, Levin JZ, Cummins C, Anderson P, Horvitz HR; , J Neurosci. 2003;23:9133-9145.: sup-9, sup-10, and unc-93 may encode components of a two-pore K+ channel that coordinates muscle contraction in Caenorhabditis elegans. PUBMED:14534247 EPMC:14534247
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This tab holds annotation information from the InterPro database.
InterPro entry IPR010291
The proteins in this family are represented by UNC-93 from Caenorhabditis elegans. UNC-93 colocalizes with SUP-10 and SUP-9 within muscle cells. Genetic studies suggest that these three proteins forms complex that coordinates muscle contraction. The function of UNC-93 is not known but is most likely an ion channel regulatory protein [PUBMED:14534247].
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The major facilitator superfamily (MFS) is one of the two largest families of membrane transporters found on Earth . It is present ubiquitously in bacteria, archaea, and eukarya and includes members that can function by solute uniport, solute/cation symport, solute/cation antiport and/or solute/solute antiport with inwardly and/or outwardly directed polarity . All permeases of the MFS possess either 12 or 14 transmembrane helices .
The clan contains the following 25 members:Acatn ATG22 BT1 CLN3 DUF1228 DUF791 Folate_carrier FPN1 FTR1 LacY_symp MFS_1 MFS_1_like MFS_2 MFS_3 MFS_Mycoplasma Nodulin-like Nuc_H_symport Nucleoside_tran OATP PTR2 PUCC Sugar_tr TLC TRI12 UNC-93
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Curation and family details
|Seed source:||Pfam-B_4965 (release 9.0)|
|Previous IDs:||DUF895; UNC-93_Ce;|
|Author:||Moxon SJ, Pollington J|
|Number in seed:||11|
|Number in full:||630|
|Average length of the domain:||133.40 aa|
|Average identity of full alignment:||22 %|
|Average coverage of the sequence by the domain:||29.75 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||11|
|Download:||download the raw HMM for this family|
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