Summary: QueT transporter
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QueT transporter Provide feedback
This family includes the queT gene encoding a hypothetical integral membrane protein with 5 predicted transmembrane regions. The queT genes in Firmicutes are often preceded by the PreQ1 (7-aminomethyl-7-deazaguanine) riboswitches of two distinct classes [1-2], suggesting involvement of the QueT transporters in uptake of a queuosine biosynthetic intermediate.
Roth A, Winkler WC, Regulski EE, Lee BW, Lim J, Jona I, Barrick JE, Ritwik A, Kim JN, Welz R, Iwata-Reuyl D, Breaker RR; , Nat Struct Mol Biol. 2007;14:308-317.: A riboswitch selective for the queuosine precursor preQ1 contains an unusually small aptamer domain. PUBMED:17384645 EPMC:17384645
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR010387This entry is represented by Bacteriophage Dp-1, QueT. The characteristics of the protein distribution suggest prophage matches in addition to the phage matches.
This family includes the queT gene encoding a hypothetical integral membrane protein with 5 predicted transmembrane regions. The queT genes in Firmicutes are often preceded by the PreQ1 (7-aminomethyl-7-deazaguanine) riboswitches of two distinct classes [PUBMED:17384645, PUBMED:18305186], suggesting involvement of the QueT transporters in uptake of a queuosine biosynthetic intermediate.
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This superfamily includes a wide range of transporters that contain many conserved glycine residues in the presumed transmembrane regions.
The clan contains the following 12 members:5TM-5TMR_LYT Bac_export_3 BioY CbiM DUF2232 DUF3816 ECF-ribofla_trS Hpre_diP_synt_I MreD QueT Thia_YuaJ ThiW
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Curation and family details
|Seed source:||Pfam-B_10800 (release 9.0)|
|Author:||Moxon SJ, Rodionov D, Bateman A|
|Number in seed:||45|
|Number in full:||1266|
|Average length of the domain:||152.20 aa|
|Average identity of full alignment:||33 %|
|Average coverage of the sequence by the domain:||91.44 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||6|
|Download:||download the raw HMM for this family|
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