Summary: Bor protein
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This family consists of several Bacteriophage lambda Bor and Escherichia coli Iss proteins. Expression of bor significantly increases the survival of the Escherichia coli host cell in animal serum. This property is a well known bacterial virulence determinant indeed, bor and its adjacent sequences are highly homologous to the iss serum resistance locus of the plasmid ColV2-K94, which confers virulence in animals. It has been suggested that lysogeny may generally have a role in bacterial survival in animal hosts, and perhaps in pathogenesis .
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This tab holds annotation information from the InterPro database.
InterPro entry IPR010438
This family consists of several Bacteriophage lambda Bor and Escherichia coli Iss proteins. Expression of bor significantly increases the survival of the E. coli host cell in animal serum. This property is a well known bacterial virulence determinant. Indeed, bor and its adjacent sequences are highly homologous to the iss serum resistance locus of the plasmid ColV2-K94, which confers virulence in animals. It has been suggested that lysogeny may generally have a role in bacterial survival in animal hosts, and perhaps in pathogenesis [PUBMED:2144037].
Bor and Iss have been shown to be present on the outer membrane of E. coli, where they may be recognised by the host's immune system [PUBMED:17309614].
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
|Cellular component||cell outer membrane (GO:0009279)|
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Superfamily consists of those protein families wherein the lipo-protein attachmnet motif, usually at the N-terminus, is found. regions of sequence downstream of this motif may not be conserved between families in the clan.
The clan contains the following 3 members:Lambda_Bor LPAM_1 MLTD_N
We make a range of alignments for each Pfam-A family:
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Curation and family details
|Seed source:||Pfam-B_12850 (release 9.0)|
|Number in seed:||1|
|Number in full:||1958|
|Average length of the domain:||95.40 aa|
|Average identity of full alignment:||81 %|
|Average coverage of the sequence by the domain:||97.84 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 80369284 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||7|
|Download:||download the raw HMM for this family|
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