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0  structures 98  species 0  interactions 255  sequences 5  architectures

Family: Calcyon (PF06387)

Summary: D1 dopamine receptor-interacting protein (calcyon)

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D1 dopamine receptor-interacting protein (calcyon) Provide feedback

This family consists of several D1 dopamine receptor-interacting (calcyon) proteins. D1/D5 dopamine receptors in the basal ganglia, hippocampus, and cerebral cortex modulate motor, reward, and cognitive behaviour. D1-like dopamine receptors likely modulate neocortical and hippocampal neuronal excitability and synaptic function via Ca(2+) as well as cAMP-dependent signaling [1]. Defective calcyon proteins have been implicated in both attention-deficit/hyperactivity disorder (ADHD) [2] and schizophrenia [3].

Literature references

  1. Lezcano N, Bergson C; , J Neurophysiol 2002;87:2167-2175.: D1/D5 dopamine receptors stimulate intracellular calcium release in primary cultures of neocortical and hippocampal neurons. PUBMED:11929934 EPMC:11929934

  2. Fisher SE, Francks C, McCracken JT, McGough JJ, Marlow AJ, MacPhie IL, Newbury DF, Crawford LR, Palmer CG, Woodward JA, Del'Homme M, Cantwell DP, Nelson SF, Monaco AP, Smalley SL; , Am J Hum Genet 2002;70:1183-1196.: A genomewide scan for loci involved in attention-deficit/hyperactivity disorder. PUBMED:11923911 EPMC:11923911

  3. Koh PO, Bergson C, Undie AS, Goldman-Rakic PS, Lidow MS; , Arch Gen Psychiatry 2003;60:311-319.: Up-regulation of the D1 dopamine receptor-interacting protein, calcyon, in patients with schizophrenia. PUBMED:12622665 EPMC:12622665


This tab holds annotation information from the InterPro database.

InterPro entry IPR009431

It was originally thought that the Neuron-specific vesicular protein calcyon (previously known as D1 dopamine receptor-interacting, calcyon), which this entry represents, interacted directly with the D1 dopamine receptor (DRD1) to modulate neocortical and hippocampal neuronal excitability [PUBMED:10698743] as well as cAMP-dependent signalling [PUBMED:11929934]. However, this work was retracted, as it was shown that a direct interaction with the dopamine D1 receptor had been misinterpreted [PUBMED:17170272]. However, it has been shown that calcyon induces D1DR to stimulate intracellular Ca2+ release, and this suggests a possible functional interaction between calcyon and D1DR, despite there being, as yet, no direct interaction between them. A recent study suggested that calcyon-containing vesicles might transport D1DR by associating calcyon with D1DR through their assembly to clathrin [PUBMED:16595675]. However, as a single transmembrane protein, it is currently not clear how calcyon can regulate the internalization of D1DR from the plasma membrane to endocytic vesicles.

Calcyon is a brain-specific protein, mainly localized in the intracellular endosomal vesicles of dendritic spines in dopamine expressing pyramidal cells in the prefrontal cortex and hippocampus and dorsal striatum region [PUBMED:11929934, PUBMED:10698743]. Neuron-specific vesicular protein calcyon has implicated in clathrin-mediated endocytosis. It is exclusively expressed in neurons, and localized in moving vesicles and it thought to play a role in brain plasticity [PUBMED:17885599]. Defective calcyon proteins have been implicated in both attention-deficit/hyperactivity disorder (ADHD) [PUBMED:11923911, PUBMED:17623072] and schizophrenia [PUBMED:12622665].

Gene Ontology

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  Seed
(14)
Full
(255)
Representative proteomes UniProt
(338)
NCBI
(581)
Meta
(0)
RP15
(31)
RP35
(67)
RP55
(170)
RP75
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  Seed
(14)
Full
(255)
Representative proteomes UniProt
(338)
NCBI
(581)
Meta
(0)
RP15
(31)
RP35
(67)
RP55
(170)
RP75
(235)
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Seed source: Pfam-B_15400 (release 9.0)
Previous IDs: none
Type: Family
Author: Moxon SJ
Number in seed: 14
Number in full: 255
Average length of the domain: 160.40 aa
Average identity of full alignment: 58 %
Average coverage of the sequence by the domain: 89.15 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 26740544 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 25.0 25.0
Trusted cut-off 34.9 48.6
Noise cut-off 23.3 22.7
Model length: 182
Family (HMM) version: 10
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