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15  structures 1376  species 0  interactions 2431  sequences 81  architectures

Family: UDP-g_GGTase (PF06427)

Summary: UDP-glucose:Glycoprotein Glucosyltransferase

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

The Pfam group coordinates the annotation of Pfam families in Wikipedia, but we have not yet assigned a Wikipedia article to this family. If you think that a particular Wikipedia article provides good annotation, please let us know.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

UDP-glucose:Glycoprotein Glucosyltransferase Provide feedback

This domain consists of 7 stranded beta-sandwiches found in UDP-glucose-glycoprotein glucosyltransferase-like proteins [1]. UDP-g_GGTase is an important, central component of the QC system in the ER for checking that glycoproteins are folded correctly. This QC prevents incorrectly folded glycoproteins from leaving the ER [2,3].

Literature references

  1. Roversi P, Marti L, Caputo AT, Alonzi DS, Hill JC, Dent KC, Kumar A, Levasseur MD, Lia A, Waksman T, Basu S, Soto Albrecht Y, Qian K, McIvor JP, Lipp CB, Siliqi D, Vasiljevic S, Mohammed S, Lukacik P, Walsh MA, Santino A, Zitzmann N;, Proc Natl Acad Sci U S A. 2017;114:8544-8549.: Interdomain conformational flexibility underpins the activity of UGGT, the eukaryotic glycoprotein secretion checkpoint. PUBMED:28739903 EPMC:28739903

  2. Guerin M, Parodi AJ; , J Biol Chem 2003;278:20540-20546.: The UDP-glucose:Glycoprotein Glucosyltransferase Is Organized in at Least Two Tightly Bound Domains from Yeast to Mammals. PUBMED:12649273 EPMC:12649273

  3. Prados MB, Caramelo JJ, Miranda SE;, Biochim Biophys Acta 2103;1833:3368-3374.: Progesterone regulates the expression and activity of two mouse isoforms of the glycoprotein folding sensor UDP-Glc: glycoprotein glucosyltransferase (UGGT). PUBMED:24140206 EPMC:24140206

External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR009448

The N-terminal region of this group of proteins is required for correct folding of the ER UDP-Glc: glucosyltransferase. These proteins selectively reglucosylates unfolded glycoproteins, thus providing quality control for protein transport out of the ER. Unfolded, denatured glycoproteins are substantially better substrates for glucosylation by this enzyme than are the corresponding native proteins. This protein and transient glucosylation may be involved in monitoring and/or assisting the folding and assembly of newly made glycoproteins, in order to identify glycoproteins that need assistance in folding from chaperones

Gene Ontology

The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

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We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

Representative proteomes UniProt
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Representative proteomes UniProt

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We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

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You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...


This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Pfam-B_4648 (release 8.0)
Previous IDs: none
Type: Domain
Sequence Ontology: SO:0000417
Author: Studholme DJ , Wood V , El-Gebali S
Number in seed: 155
Number in full: 2431
Average length of the domain: 106.6 aa
Average identity of full alignment: 49 %
Average coverage of the sequence by the domain: 7.23 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 26.2 26.2
Trusted cut-off 26.2 27.6
Noise cut-off 26.1 25.6
Model length: 109
Family (HMM) version: 14
Download: download the raw HMM for this family

Species distribution

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Colour assignments

Archea Archea Eukaryota Eukaryota
Bacteria Bacteria Other sequences Other sequences
Viruses Viruses Unclassified Unclassified
Viroids Viroids Unclassified sequence Unclassified sequence


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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

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The tree shows the occurrence of this domain across different species. More...


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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the UDP-g_GGTase domain has been found. There are 15 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A044SP17 View 3D Structure Click here
A0A077YXS6 View 3D Structure Click here
A0A0D2EL79 View 3D Structure Click here
A0A0K0E8S0 View 3D Structure Click here
A0A0N4UDJ8 View 3D Structure Click here
A0A0R0K2I7 View 3D Structure Click here
A0A175VUN3 View 3D Structure Click here
A0A1C1CHF5 View 3D Structure Click here
A0A1D6HNS8 View 3D Structure Click here
A0A1D8PJN6 View 3D Structure Click here
A0A2R8PZV9 View 3D Structure Click here
A0A3Q0KM82 View 3D Structure Click here
A0A5K4EMD1 View 3D Structure Click here
A4I4S1 View 3D Structure Click here
C0NGU3 View 3D Structure Click here
C1H9J0 View 3D Structure Click here
E7F6G9 View 3D Structure Click here
E9Q4X2 View 3D Structure Click here
F1R7F6 View 3D Structure Click here
G5EF14 View 3D Structure Click here
I1KSR4 View 3D Structure Click here
I1KUN0 View 3D Structure Click here
Q09140 View 3D Structure Click here
Q09332 View 3D Structure Click here
Q0WL80 View 3D Structure Click here
Q4E3K0 View 3D Structure Click here
Q582S2 View 3D Structure Click here
Q6P5E4 View 3D Structure Click here
Q8T191 View 3D Structure Click here
Q9GPA0 View 3D Structure Click here
Q9JLA3 View 3D Structure Click here
Q9NYU1 View 3D Structure Click here
Q9NYU2 View 3D Structure Click here
U7Q7C7 View 3D Structure Click here