Summary: Bacterial Na+/H+ antiporter B (NhaB)
Bacterial Na+/H+ antiporter B (NhaB) Provide feedback
This family consists of several bacterial Na+/H+ antiporter B (NhaB) proteins. The exact function of this family is unknown [1,2].
Enomoto H, Unemoto T, Nishibuchi M, Padan E, Nakamura T; , Biochim Biophys Acta 1998;1370:77-86.: Topological study of Vibrio alginolyticus NhaB Na+/H+ antiporter using gene fusions in Escherichia coli cells. PUBMED:9518558 EPMC:9518558
Herz K, Vimont S, Padan E, Berche P; , J Bacteriol 2003;185:1236-1244.: Roles of NhaA, NhaB, and NhaD Na+/H+ antiporters in survival of Vibrio cholerae in a saline environment. PUBMED:12562793 EPMC:12562793
Internal database links
|Similarity to PfamA using HHSearch:||CitMHS|
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR004671
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
|Cellular component||integral to membrane (GO:0016021)|
|Molecular function||sodium:hydrogen antiporter activity (GO:0015385)|
|Biological process||sodium ion transport (GO:0006814)|
- the number of sequences which exhibit this architecture
a textual description of the architecture, e.g. Gla, EGF x 2, Trypsin.
This example describes an architecture with one
Gladomain, followed by two consecutive
EGFdomains, and finally a single
- the UniProt description of the protein sequence
- the number of residues in the sequence
- the Pfam graphic itself.
Loading domain graphics...
This superfamily of secondary carriers specific for cationic and anionic compounds, has been termed the ion transporter (IT) superfamily .
The clan contains the following 17 members:ABG_transport ArsB CitMHS DctM DcuA_DcuB DcuC DUF1504 DUF1646 DUF401 GntP_permease Lactate_perm MatC_N Na_H_antiport_2 Na_H_antiporter Na_sulph_symp NhaB SCFA_trans
We make a range of alignments for each Pfam-A family:
- the curated alignment from which the HMM for the family is built
- the alignment generated by searching the sequence database using the HMM
- Representative Proteomes (RPs) at 15%, 35%, 55% and 75% co-membership thresholds
- alignment generated by searching the NCBI sequence database using the family HMM
- alignment generated by searching the metagenomics sequence database using the family HMM
You can see the alignments as HTML or in three different sequence viewers:
- Pfam viewer
- an HTML-based viewer that uses DAS to retrieve alignment fragments on request
1Cannot generate PP/Heatmap alignments for seeds; no PP data available
Key: available, not generated, — not available.
Format an alignment
If you find these logos useful in your own work, please consider citing the following article:
Note: You can also download the data file for the tree.
Curation and family details
|Seed source:||Pfam-B_5993 (release 10.0)|
|Number in seed:||4|
|Number in full:||838|
|Average length of the domain:||497.90 aa|
|Average identity of full alignment:||75 %|
|Average coverage of the sequence by the domain:||99.01 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||7|
|Download:||download the raw HMM for this family|
Weight segments by...
Change the size of the sunburst
selected sequences to HMM
a FASTA-format file
- 0 sequences
- 0 species
How the sunburst is generated
Colouring and labels
Anomalies in the taxonomy tree
Missing taxonomic levels
Unmapped species names
Too many species/sequences
The tree shows the occurrence of this domain across different species. More...
You can use the tree controls to manipulate how the interactive tree is displayed:
- show/hide the summary boxes
- highlight species that are represented in the seed alignment
- expand/collapse the tree or expand it to a given depth
- select a sub-tree or a set of species within the tree and view them graphically or as an alignment
- save a plain text representation of the tree