# STOCKHOLM 1.0 #=GF ID Mob_synth_C #=GF AC PF06463.14 #=GF DE Molybdenum Cofactor Synthesis C #=GF AU Yeats C;0000-0003-0080-6242 #=GF SE ADDA_4938 #=GF GA 37.40 37.40; #=GF TC 37.40 38.50; #=GF NC 37.00 37.30; #=GF BM hmmbuild HMM.ann SEED.ann #=GF SM hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq #=GF TP Domain #=GF DR INTERPRO; IPR010505; #=GF DR SO; 0000417; polypeptide_domain; #=GF CC This region contains two iron-sulphur (3Fe-4S) binding sites. #=GF CC Mutations in this region of Swiss:O14940 cause MOCOD #=GF CC (Molybdenum Co-Factor Deficiency) type A. #=GF SQ 52 #=GS MOAA_CAMJE/181-303 AC Q9PIW6.1 #=GS MOAA_HELPY/181-304 AC P56414.1 #=GS D5AP67_RHOCB/188-314 AC D5AP67.1 #=GS MOAA_CAUVC/204-331 AC Q9AC48.1 #=GS MOAA_BRADU/197-324 AC Q89NT2.1 #=GS MOAA_BRUA2/197-323 AC Q2YNT7.1 #=GS MOAA_RHIME/202-329 AC Q92PB4.1 #=GS MOAA_AGRFC/202-329 AC Q8UER0.1 #=GS MOAA1_PSEAE/183-312 AC Q9HXD6.1 #=GS MOAA_PSESM/185-315 AC Q882V6.1 #=GS MOAA_PSEPK/187-317 AC Q88E69.1 #=GS Q8E8E1_SHEON/183-311 AC Q8E8E1.1 #=GS MOAA2_PSEAE/185-314 AC Q9I3K7.1 #=GS MOAA_CLOAB/180-301 AC Q97HL8.1 #=GS W8U461_PEPAC/187-308 AC W8U461.1 #=GS MOCS1_CAEEL/244-371 AC Q20624.3 #=GS MOCS1_DROME/240-368 AC Q8IQF1.1 #=GS MOCS1_HUMAN/241-368 AC Q9NZB8.3 #=GS CNX2_ARATH/246-373 AC Q39055.1 #=GS Q88K11_PSEPK/180-311 AC Q88K11.1 #=GS Q88LG4_PSEPK/195-326 AC Q88LG4.1 #=GS Q8FQ34_COREF/231-364 AC Q8FQ34.1 #=GS MOAA_CORGL/227-360 AC Q8NR60.1 #=GS MOAA_STRCO/195-324 AC Q9RJ47.1 #=GS MOAA2_MYCTU/211-342 AC P9WJS1.1 #=GS MOAA1_MYCTU/203-326 AC P9WJS3.1 #=GS MOAA_SYNPW/204-328 AC Q9EYN8.1 #=GS MOAA_AQUAE/183-302 AC O67929.1 #=GS MOAA_BACSU/193-321 AC P39757.1 #=GS MOAA_BACHD/191-319 AC Q9K9W9.1 #=GS MOAA_STAA8/189-317 AC P69848.1 #=GS MOAA_STAA8/189-317 DR PDB; 2FB2 A; 189-318; #=GS MOAA_STAA8/189-317 DR PDB; 2FB3 A; 189-318; #=GS MOAA_STAA8/189-317 DR PDB; 2FB2 B; 189-318; #=GS MOAA_STAA8/189-317 DR PDB; 2FB3 B; 189-318; #=GS MOAA_STAEQ/189-317 AC Q5HLY1.1 #=GS MOAA_XANCP/194-320 AC Q8PBX1.1 #=GS MOAA_RALSO/196-324 AC Q8Y0K4.2 #=GS MOAA_PYRAE/181-306 AC Q8ZYE5.1 #=GS MOAA_THEAC/179-306 AC Q9HKZ7.1 #=GS MOAA_METTH/179-305 AC O27593.2 #=GS MOAA_AERPE/183-313 AC Q9YEV3.1 #=GS MOAA_SACS2/177-306 AC Q980F0.1 #=GS MOAA_SULTO/177-305 AC Q971H1.1 #=GS MOAA_CHLTE/188-315 AC P59038.1 #=GS MOAA_LACPL/184-309 AC Q88WY1.1 #=GS MOAA_LISMO/184-310 AC Q8Y870.1 #=GS MOAA_SYNE7/184-311 AC Q56211.1 #=GS Q8E941_SHEON/194-321 AC Q8E941.2 #=GS MOAA_ECOLI/186-313 AC P30745.1 #=GS MOAA_YERPE/183-310 AC Q8ZGW5.1 #=GS MOAA_HAEIN/194-321 AC P45311.1 #=GS MOAA_VIBCH/191-318 AC Q9KT81.1 #=GS MOAA_VIBVY/191-316 AC Q7MM75.2 #=GS MOAA_NOSS1/181-309 AC Q8YQG6.1 #=GS MOAA_CLOPE/180-306 AC Q9WX96.2 MOAA_CAMJE/181-303 AQIRFIEFMENTHAYGK......LQGLKRDEIIQILSQKYQI..QLIK.KDE...KAPVSIYKA.....DDYE....FGIIDPHSHE.FCDSCNRIRLSAEGLLIPCLYFDEA.LSIKEAVRKG..DIKA...AVEILQEVLRNKPEKNKW MOAA_HELPY/181-304 IQIRYIEFMENTHAKSL......VKGLKEREILDLIAQKYQI..IEAE.KPK...QGSSKIYTL.....ENGY..Q.FGIIAPHSDD.FCQSCNRIRLASDGKICPCLYYQDA.IDAKEAIINK..DTKN...IKRLLKQSVINKPEKNMW D5AP67_RHOCB/188-314 .DLTFIELMPMGDIPAGTRL...DQFWPLDDVRAHLETRFRL..IDNG.LNT...GGPARYVTV.....AQTG.QR.IGFISPLSHN.FCTSCNRVRLTCKGELYTCLGQEGS.SDLRPVLRAGV.EGEA...LAREIRAAIARKPAGHA. MOAA_CAUVC/204-331 CDITLIETMPLGEVDQD.RT...DQFLSLQDVRRDLSSFWTL..TDIP.DST...GGPARYVHV.....AETG.GR.LGLITPLSNH.FCDTCNRVRLTCTGTLHTCLGRDDA.SDLRAEIRRGASDAE....LVDAIHLAIGAKPKGHDF MOAA_BRADU/197-324 MGLTLIEVMPMGEIGAG.RI...DQYLPLSLVRARLAQQFTL..MDLA.EST...GGPARYVSV.....AETG.GK.LGFITPMTHN.FCESCNRVRITCTGTLHTCLGHEDA.SDLRKPLRASDDDML....LADAIDRAIGLKPKGHDF MOAA_BRUA2/197-323 MDVTLIETMPMGEIEFD.RT...DQYLPLSQVRADLASQFTL..ADIP.YRT...GGPARYVTI.....SETG.GR.LGFITPMTYN.FCESCNRVRLTCTGMLYMCLGQNDD.ADLRKALRESE.SDEH...LSQAIDEAISRKPKGHD. MOAA_RHIME/202-329 MDLTLIETMPMGEVDED.RT...DHYLPLSEMRRRLEADFTL..SDIP.YRT...GGPARYVEV.....AETG.GR.LGLITPLTHN.FCESCNRVRLTCTGTLYMCLGQNDA.ADLRAALRATDDDAY....LAQVIDEAIGRKPKGHDF MOAA_AGRFC/202-329 MDLTVIETMPMGEIEED.RT...DRYLPLSQLRADLERNFTL..VDSD.YQT...GGPARYVTV.....KETG.GR.LGFITPMTHN.FCESCNRVRLTCTGTLYMCLGQDDA.ADLRTALRASDSDAY....LSAAIDEALLRKPKGHDF MOAA1_PSEAE/183-312 LDISFIEEMPLGQVGRE.RG...ESFCSSDEVRALIAQRHAL..LDSA.EQS...GGPARYVRL.....VEHPQTR.IGFISPHSHN.FCATCNRLRLTVEGRLLLCLGHEHS.LDLRALLRRHPLHDGP...LLEAIGEALQRKPARHEF MOAA_PSESM/185-315 LDVSFIEEMPLGIISEHSRA...ESFYSSDQVRERIAERYTL..IPST.DST...QGPSRYWRL.....AQAPGIR.IGFISPHSHN.FCGTCNRVRLTVEGRLLLCLGNEHS.VDLKAVLRATPGQPEK...LEKAIIDAMQLKPWSHNF MOAA_PSEPK/187-317 LDITFIEEMPLGVISEHERG...ESFCSSDEVRARLAEQFTL..VEST.ESS...MGPARYWRL.....AEAANTR.VGFISPHSHN.FCATCNRVRLTVEGRLLLCLGNEHS.VDLKHVLRAHPGNPER...LEKAIRDSLHLKPYRHHF Q8E8E1_SHEON/183-311 LDIAFIEEMPLGEMDER.KR...ARHCSSDEVKAMISEHYPL..QLSN.KRT...GGPARYYTM.....ADSP.IH.IGFISPHSHN.FCHECNRVRVTVEGQLLLCLGNEHS.IDLKSIIREFPGDIER...LKTAILQGIKRKPKQHVF MOAA2_PSEAE/185-314 LDISFIEEMPLGSITSHRRE...LTLCTSDEVRAIIERRWPL..TPSL.ARS...GGPSRYYQI.....GDEP.SR.IGFISPHSNN.FCGDCNRVRVTAEGKLVLCLGHEGA.LDLRELLRSHPGDRER...LSAALVAALNLKPERHHF MOAA_CLOAB/180-301 VEIRFIELMPIGEGAKI.YE...KGRVNIKELLMSRSDLIPI..ESLQ.......NSTANMYKI.....KGGK.GR.IGYITPISCK.FCSTCNKIRLTSMGTIKPCLHSNQE.IDLKPYLNNED.V......LVEKLKTIIFNKTFQHHI W8U461_PEPAC/187-308 IDVRFIELMPIGQAAGW.SL...EKFISSDSVLKKVPSLEKI..KSE...DI...SSPAEYYRI.....PGAL.GK.VGLINPITCK.FCENCNRIRLTSDGKLKLCLHSDSE.IDLAGPLRRGE....D...IRGIVLDEIKNKPREHS. MOCS1_CAEEL/244-371 LDVRFIEFMPFG.GNEF.KN...DNFIGYREMLNLIVDKYGDGVIRLS.DSP...NDTTKAYKI.....DGFQ.GQ.FGFITSMSDH.FCNTCNRLRITADGNLKVCLHGNSE.VSLRDRIRCGD.SDEQ...LSEVIQKAVNNKKARHA. MOCS1_DROME/240-368 VDVRFIEYMPFS.GNKW.HT...ERLISYKDTLQIIRQRWPD..FKALPNGP...NDTSKAYAV.....PGFK.GQ.VGFITSMTEH.FCGTCNRLRLTADGNIKVCLFGNKE.FSLRDAMRDESVSEEQ...LVDLIGAAVQRKKKQHAD MOCS1_HUMAN/241-368 LDVRFIEYMPFD.GNKW.NF...KKMVSYKEMLDTVRQQWPE..LEKVPEEE...SSTAKAFKI.....PGFQ.GQ.ISFITSMSEH.FCGTCNRLRITADGNLKVCLFGNSE.VSLRDHLRAGA.SEQE...LLRIIGAAVGRKKRQHAG CNX2_ARATH/246-373 INVRFIEFMPFD.GNVW.NV...KKLVPYAEVMDKVVKRFPS..IKRMQDHP...TETAKNFTI.....DGHC.GS.VSFITSMTEH.FCAGCNRLRLLADGNFKVCLFGPSE.VSLRDPLRSGA.DDEA...LREIIGAAVKRKKAAHAG Q88K11_PSEPK/180-311 YELRFIELMRMGHLAQH.AQAFRTQFVGQRELLELIGERYAF..TQAE.APV...DSTALRYSV.......GERGA.FGIIANESAP.FCRSCSRLRLSSTGRLYGCLSSNRG.HFMGTLLDLP..TEQAQPQLTALLGRALADKQDATFT Q88LG4_PSEPK/195-326 FELRFIELMRMGHLSHD.RNAFLQQFVGLDQLLALIGGQHAY..AQVN.APL...DATAMRYHI.......PGRGH.FGVIANESVP.FCRTCSRLRLSSTGWLHGCLSSGNR.HFVGDLLEKP..RHQALPALQRLLVKALADKQDVAFS Q8FQ34_COREF/231-364 AQLRFIEQMPLGPREQW.RR...GDMVTAAQIFERLEQAFIL..SPA..REPR.GSAPAALWNATDRNNTSVT.GT.LGIIASVTHP.FCGDCDRSRLTSDGTIRNCLFARTE.TPLRDIMRAGA.TDEE...LAAVWAGAMWVKKPGHGI MOAA_CORGL/227-360 SQLRFIEQMPLGPREQW.KR...GDMVTAEEILARLEEKFTL..SPA..KEPR.GAAPAALWNVVDKSNPDIT.GQ.IGIIASVTHP.FCGDCDRSRLTTDGTIRNCLFSRTE.TPLRDALRDGA.SDDE...LAQLWAGAMWEKKPGHGI MOAA_STRCO/195-324 YELRFIEQMPLDAQHGW.KR...EGMVTAGDILTSLRTRFEL..TAEG.SEER.GSAPAERWLV.....DGGP.HR.VGVIASVTRP.FCSACDRTRLTADGQVRTCLFATEE.TDLRAALRSDA.PDEE...IARIWRLAMWGKKAGAGL MOAA2_MYCTU/211-342 YQLRVIEQMPLDAGHSW.RR...NIALSADDVLAALRPHFRL..RPDP.APR..GSAPAELWLVDA.GPNTPR.GR.FGVIASVSHA.FCSTCDRTRLTADGQIRSCLFSTEE.TDLRRLLRGGA.DDDA...IEAAWRAAMWSKPAGHG. MOAA1_MYCTU/203-326 .EVRFIEYMDVGGATHW.AW...EKVFTKANMLESLEKRYGR..IEPLPKHD...TAPANRYAL.....PDGT..T.FGIIASTTEP.FCATCDRSRLTADGLWLHCLYAISG.INLREPLRAGA.THDD...LVETVTTGWRRRTDR... MOAA_SYNPW/204-328 VELRLIEYMDVGNRNGW.AP...DQVISAAEMVQRIDARWPL..RPLPRES....GATSRRWSY.....ADGR.GR.IGTIASITEP.FCGDCNRLRVTADGQAFTCLFASEG.TDLRPFLHSEET.......LEAVVRGLWQQRRDRYSE MOAA_AQUAE/183-302 VTLRFIEYMDVGTVNDW.DF...SKVVSADEILNLMKKEFTF..YPL.PKRP...EDTSMDFIY.....EDGN..K.FGIIASVTKP.FCRGCNRIRLSADGKLYTCLFSDKG.HDLRNAVDKEN...........FIKEVWKDRKDRYSE MOAA_BACSU/193-321 HILRFIEFMDVGNTNQW.EK...KDVMTKAEIIDLINKHMPV..EPIAPNYI...GEVASRFRY.....LDGS.GE.IGVISSVSDA.FCGSCNRARLSARGELFTCLFASSG.FDLRAPVRQEL.SDDE...LSEMIGTVWKNRIDQYSV MOAA_BACHD/191-319 YTLRFIEYMDVGNSNGW.RM...DDVVAKRDILEMIHKVHPL..EPVDPEYP...GEVATRYRY.....KGTS.VE.IGVISSVTDA.FCTTCNRARLSVEGKLYTCLFATKG.HDFRELLRSGA.SDEE...IQQKLAAIWHVRDDKYSL MOAA_STAA8/189-317 IEIRFIEFMDVGNDNGW.DF...SKVVTKDEMLTMIEQHFEI..DPVE.PKY..FGEVAKYYRH.....KDNG.VQ.FGLITSVSQS.FCSTCTRARLSSDGKFYGCLFATVDGFNVKAFIRSGV.TDEE...LKEQFKALWQIRDDRYS. #=GR MOAA_STAA8/189-317 SS -EEEEEE---B-TTSSB.--...SSB--HHHHHHHHHHHS-E..EEE-.-SS..TT-SSEEEEE.....TTT-.-E.EEEE-TTTS-.-GGG--EEEE-TTSEEESSSS-SS--EEHHHHHHTT-.-HHH...HHHHHHHHHHT----HH. MOAA_STAEQ/189-317 IEVRFIEFMDVGNDNGW.NF...NKVVTKEEMLNMIEQHFEI..SPVAPKYY...GEVAKYFRH.....KDSD.AQ.FGLITSVSES.FCSTCTRARLSSDGKFYGCLFASSEGFDVKALIRNGA.TDDD...LKAQFKRLWSIRNDQYS. MOAA_XANCP/194-320 HVLRFIEFMDVGSCNGW.RP...EAVVTSAQLRDRIHARWPL..APLDANYT...GEVAQRHAF.....ADGL.GE.VGFVSSVSVP.FCGDCQRARVSADGHLYTCLFASQG.HDLKPALAEGEQG......LATHLRQRWSVRADRYSE MOAA_RALSO/196-324 IILRFIEYMDVGVTNHW.EM...ASVVPSAEVIRRLSAAFAL..EPLSANYA...GETAERWRY.....ADGA.GE.IGVISSVTQA.FCHDCTRARLSTEGKLYLCLFATQG.FDLRALLRGGA.SDLE...VSNAIRTVWQARTDRYSE MOAA_PYRAE/181-306 AALQFIELMPSGWGA........SVFNELYEPIETLVNIIFE..LGGRPAGVRKELHNRPLYNI.....AGVT....VELIKNFSNPTFCSGCTTMRLTSDGKLKTCIYADSS.VDLMPYIKSRDVEG.....LLYAVRTALARREPRFKL MOAA_THEAC/179-306 AILQLIEYETDREGESS......EEYRRYHISLDPIEAQIRK..KAIG.VEYN.DLHNRPRYLM.....KNDHGVVKIEFVKPQRNPDFCAHCTRLRITSRGEFKTCLMRSDTNVPFKGVTDENR........LRDLFRIAVSLREPYWKP MOAA_METTH/179-305 AVLQIIELLKTESCHD.......DAVERYHCDITPIEAELAE..MADR.IRTRKFMQDRKKYYI.....DGGE....IEVVRPMDNTRFCANCTRLRVTPDGKLKPCLLRNDNLVDTRDALRENDTGR.....LRELFFEAIRRRSPYYTP MOAA_AERPE/183-313 FDLQVIEVHPAGRGR........KVLSSFRRPIDVVEERLSS..MAVA.VETG.RLHNRRVYRL.....PSGVR...VYLVDPVENPVFCMGCYRVRLTWDGRLLPCIYWKGPYPSVAEALKRGGSREEKVWRVMKILLEANALRRPTYLF MOAA_SACS2/177-306 NEIHLIELHPVGLG.........KLAFKEHDDLREIEEYIEK..ISIK.KLIR.KKHFRPRYVL.....PSGLI...VEVVKPYANPIFCAGCNRIRLSVDGKLKTCLYREDNVIDVLDILKGEYSEDVKEELLGRAFMIAIAIREPNFKY MOAA_SULTO/177-305 DELHLIELHPVGLG.........KNTFEYHEKLESIEKILKE..RADK.IEIR.SKHYRPRYYL.....NNLV....IEVVKPYANPIFCAGCNRIRLTADGKLKTCLYRQDKEIDIMDILRGDFSLEEKIELIREAYEIAIAIREPNFKY MOAA_CHLTE/188-315 LTVRFMELQPFDDHQIW.RT...GRFMGAERIRERLADAYPE..LEAI.T.....GHSTEHYSFS...LPGHR.GS.IAIIPAFSRN.FCSSCSKLRITADARLISCLYHHES.IDLAPALKGEM.NEVE...LKKRIIEAVQQKPKDGLK MOAA_LACPL/184-309 VNARFIEFMPIGNSLKT.WQ...KEYVGLKNVFDTCKDNGLA..YHPIVLRG...NGPSDNYQI.....EGYE.GS.FGLIHPISSK.FCENCNRLRITADGYVKACLYWNEE.IDIRSAIGDPV.A......FRKLIQKALDNKPLNHEM MOAA_LISMO/184-310 INIRFIEYMPIGHAGTS.WK...EKYLPLDTIFEACNEAGYE..YEPVDSIR..GNGPSENFRI.....KGAK.GT.FGVIHPVSAH.FCDSCNRLRLTADGYIKACLYWDEE.MNIRPFIQDPV.K......LMQLVQKAIDNKPENHEM MOAA_SYNE7/184-311 ISIRFIELMQTLDNHDY.FQ...QEFLSGSVLTEQWLAQGWQ..PIKR.DRT...AGPAQEYCH.....PNYQ.GK.LGIIAPYSPN.FCQNCNRLRVTSRGALRLCLFGTGE.FDLRPWLQHPD.QRSQ...LLEQVQQTLSFKTAGHQL Q8E941_SHEON/194-321 IDLRFIELMETGLGREY.FQ...AHHLAGADIKALLQAEGWQ..LDIP.SAD...DGPAQNFSH.....SDFK.GR.IGLIMPYATN.FCASCNRLRVSAKGKLHLCLFTESG.IDLRDLLQHPS.QQAE...LIERLHGQLAQKKETHYL MOAA_ECOLI/186-313 IQLRFIELMETGEGSEL.FR...KHHISGQVLRDELLRRGWI..HQLR.QRS...DGPAQVFCH.....PDYA.GE.IGLIMPYEKD.FCATCNRLRVSSIGKLHLCLFGEGG.VNLRDLLEDDT.QQQA...LEARISAALREKKQTHFL MOAA_YERPE/183-310 IQLRFIELMETGEGGNL.FR...KHHVSGGVIRQQLLEQGWQ..QQDR.ARS...DGPAQVFHH.....SDYQ.GE.IGLIMPYEKD.FCASCNRLRVSALGNLHLCLFGEQG.ITLRDLLGSDD.QQDE...LIARIQSALQTKKQTHFL MOAA_HAEIN/194-321 IQMRFIELMQTGEMDSF.FD...KFHLSGQVLADKLLKNGWT..LQHK.SHT...DGPAKVFTH.....PDYA.GE.IGLIMPYEKN.FCASCNRLRVSAKGKLHLCLFGEEG.IELRDLLQSHE.QQGI...LQARIFAALQGKREHHYL MOAA_VIBCH/191-318 IQLRFIELMQTGEMDAL.FA...RHHVSGISIRDYLFGNGWL..LKAR.ADN...DGPAQVFIH.....PDFQ.GE.IGLIMPYEKD.FCRSCNRLRVSALGKLHLCLFGEQG.IELRDLLQDDH.QENA...LIERIQTQLQNKAETHFL MOAA_VIBVY/191-316 IQLRFIELMQTGEMDTL.FQ...QHHVSGVAIRNHLIANGWL..LKVK.AAN...DGPAQVFVH.....PDYQ.GE.IGLIMPYEKD.FCASCNRLRVSAKGKLHLCLFGDRG.VELRDLMQQDD.QEPD...LIARIQSELQTKSVSH.. MOAA_NOSS1/181-309 WHVRFIEFMPIGNGELF.GD...RGWVSSAELRQQIRDRWGL..TDAQ.VRG...AGPADVFQI.....PGAK.GT.LGFISQMSEC.FCDRCNRMRLSADGWLRPCLLNETGQLDLKTSLRSGV.SIHQ...LREQVRHLLAIKPEINYK MOAA_CLOPE/180-306 IDLRFIELMPIGEGKKF.......KGVTNSEILEIIKKEKKV..LSD..GKTLRLNGPAKYISI.....EGFK.GK.IGFISAMSDC.FCEDCNRIRVTPEGFMKQCLHWKYG.INLRDKMRNGI.SDEE...LREIIKKSIYEKPEKHNF #=GC SS_cons -EEEEEE---B-TTSSB.--...SSB--HHHHHHHHHHHS-E..EEE-.-SS..TT-SSEEEEE.....TTT-.-E.EEEE-TTTS-.-GGG--EEEE-TTSEEESSSS-SS--EEHHHHHHTT-.-HHH...HHHHHHHHHHT----HH. #=GC seq_cons hplRFIEhMshGpssph.t....cphlstpclhptlpppahh..hsht.tps...susAphapl.....ssst.Gp.lGlIsshocs.FCssCNRlRLTu-GpLhsCLaspps.hDLRshL+sss.sppt...LtphlppultpK.ppath //