# STOCKHOLM 1.0
#=GF ID   Neogenin_C
#=GF AC   PF06583.13
#=GF DE   Neogenin C-terminus
#=GF PI   Neogenin_C-term; 
#=GF AU   Vella Briffa B;0000-0003-4380-1783
#=GF SE   Pfam-B_16188 (release 10.0)
#=GF GA   25.00 25.00;
#=GF TC   25.20 25.20;
#=GF NC   24.80 24.80;
#=GF BM   hmmbuild --amino HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   9121761
#=GF RT   Identification and characterization of neogenin, a DCC-related
#=GF RT   gene. 
#=GF RA   Meyerhardt JA, Look AT, Bigner SH, Fearon ER; 
#=GF RL   Oncogene 1997;14:1129-1136.
#=GF RN   [2]
#=GF RM   9264410
#=GF RT   Mouse Neogenin, a DCC-like molecule, has four splice variants
#=GF RT   and is expressed widely in the adult mouse and during
#=GF RT   embryogenesis. 
#=GF RA   Keeling SL, Gad JM, Cooper HM; 
#=GF RL   Oncogene 1997;15:691-700.
#=GF DR   INTERPRO; IPR010560;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This family represents the C-terminus of eukaryotic neogenin
#=GF CC   precursor proteins, which contains several potential
#=GF CC   phosphorylation sites [1]. Neogenin is a member of the N-CAM
#=GF CC   family of cell adhesion molecules (and therefore contains
#=GF CC   multiple copies of Pfam:PF00047 and Pfam:PF00041) and is closely
#=GF CC   related to the DCC tumour suppressor gene product - these
#=GF CC   proteins may play an integral role in regulating differentiation
#=GF CC   programmes and/or cell migration events within many adult and
#=GF CC   embryonic tissues [2].
#=GF SQ   13
#=GS E2C3E0_HARSA/1139-1459      AC E2C3E0.1
#=GS E2A6Y7_CAMFO/1145-1462      AC E2A6Y7.1
#=GS F4W5X3_ACREC/1169-1484      AC F4W5X3.1
#=GS E0VHD5_PEDHC/1113-1420      AC E0VHD5.1
#=GS J9JMG5_ACYPI/1135-1433      AC J9JMG5.2
#=GS F7B3P5_XENTR/1134-1438      AC F7B3P5.1
#=GS NEO1_CHICK/1143-1443        AC Q90610.1
#=GS A0A0R4IP15_DANRE/1135-1428  AC A0A0R4IP15.1
#=GS W5NCR8_LEPOC/1145-1445      AC W5NCR8.1
#=GS H0X2Y4_OTOGA/1120-1417      AC H0X2Y4.1
#=GS W5L4H6_ASTMX/1133-1423      AC W5L4H6.2
#=GS G3Q2S1_GASAC/1097-1393      AC G3Q2S1.1
#=GS H3D9L5_TETNG/1131-1421      AC H3D9L5.1
E2C3E0_HARSA/1139-1459                 IKPPDLWIHHDQMELKALEKS...SLNGEASTSGVTSNTLPRSGNSEYNQDNVHGNSSSLDKRTYVPSYMGN.......TDEKCS.......TLSRQHSRGSHKPKLISLPVDSAPLHQPIATATPIVNTSMSQPTIHSSCSDTSSVRQNYPRTVAQYSL.SRAHVTLEPT...PESS...................PDSCNIP....NSYE..PLQSQLSYGTSGQSYSGNAQYAPGHYGNSSQPMSSNTVGVESNSS....KRLQGHPLKSFSVPAPPPQSA........PSTPAQQKHGVSQVTVRPTMSGSPYKKPP......QSSSSQLAAKNRL....ASVSNTAHTSEE.VERL.....KPSYSTEELNQEMANLEGLMKDLNAITAS
E2A6Y7_CAMFO/1145-1462                 IKPPDLWIHHDQMELKALEKS...SLNGEPSTSGVTSNTLPRSSNLEYNQDNVHGNSSSLDKRTYVPSYMGN.......TDEKCS.......TLSRQHSRGSHKPKLITLPVDSTPLHQPIATATPIVNTSMSQPTIHTSCSDTSSVRQNYPRTVAQYSL.NRAHVTLEPT...PESS...................PDSCNMP....SSYE..PLQSQLSYGTSGQSYSGSTQYAPGH.YGGSNQPMSNTVGMESNNS....KRLQGHPLKSFSVPAPPPQSA........PSTPAQQKHGVSQVTVRPTMSGSPYKKP.......QSSSSQL.AKNRL....ASVSNPTHTSEE.VERL.....KPSYSTEELNQEMANLEGLMKDLNAITAS
F4W5X3_ACREC/1169-1484                 IKPPDLWIHHDQMELKALEKS...SLNGEASTSGVTSNTLPRSGNQEYNQDNIHGNSSSLDKRTYVPSYMGN.......TDEKCS.......TLSRQHSRGSHKSKLITLPIDSAPLHQPIATATPIVNSSMSQPTIHTSCSDTSSVRQNYPRTVAQYSL.NRAHVTLEPT...PESS...................PDSC.IP....SSYE..PLQNQLSYGTSGQSYSGNTQYASGH.YGNNTQPVSSAVG.ENNTS....KRLQGHPLKSFSVPAPPPQSA........PSTPAQQKHGVSHVTVRPTMSGSPYKKS.......QGSSSQL.TKNRL....ASVSNPAHTSEE.VERL.....KPSYSTEELNQEMANLEGLMKDLNAITAS
E0VHD5_PEDHC/1113-1420                 MKPPDLWIHHDQMELKALEKSHHSNSDIGPSSSGSQMNTLGRNGSGQTTN.DVVDHTNSLDKRTYLPSYVGGSG.CTVDQQEKTS.......TIKRT....VIKPKPISLPMETQPIAQP..........VMTNGTPLTQSPGS..ELGRPLYPRTQY....RAHITLDST...TSGTGLENPYSLQSGYDSIGTLTPTASILPNA..NTYSQNPLTSQTAMQPSLAS....................SNMTNIDNNGTL..GKRQQGHPLKSFSVPAPPPQSA........PSTP.QQKH.....VVRPLQSSSPYKKVGLHGIMGTCSPSN...........SKLRSGPGTIEE.TTRL.....QPSYSTEELNQEMANLEGLMKDLNAITAS
J9JMG5_ACYPI/1135-1433                 IKPPDLWIHHDQMELKSMEKSSQGSLD.TSSGCGQGSSNTYDGPDTRVTIHHVPQATNSLEKSNYVSSYVGNTIMKPLLSDEKVS.......TLKNR.....FKPKSVVLPVDSFD..............SVYNDTMATLPNQ....ESRSPHPKSQYATTTRAHVTVDLTAGAPENNYI.................VQATTVP....DKFESIPVSSAANLQQQHTALLNS..............SE...............KRQQGHPLKSFSVPAPPPQSA........PSTP.QQKHI...VTVRPQGSSSPYKKNIYSAINSSPSSTSVSTGPKTWKSPLTGSNQRDTITE.VESLNKI..QTSYSTEELNQEMANLEGLMKDLSAITAS
F7B3P5_XENTR/1134-1438                 VKPPDLWIHHERLELKPTDKSPETNPILTDTPLPRSPQDLTPGDSTTESS..IHQHSN.........SYRGL......ESEDSVS.......SLAGR...RGMRPK.IMMPFDSQP.PQPVVSAHPIHSHDNSH......................HFRSVPGFMLHVLGG...PPQAAVLL.......GSPCSILFLHGSNINSSVVESVRHTPSCDTVVAASSSSQTG.PEDPDP....SGVSFLPG.SLDEDSVPSVPTAHIRPSHPLKSFAVPAVPTSASGASYEPSLPSSPLLQQQ.......CPTA..LSVKT..........ASLGTLGRVRPP.LPVTVPSAPEPLE..TSRMLEGS.ECSYEPDELSKEMAHLEGLMKDLNAITTA
NEO1_CHICK/1143-1443                   VKPPDLWIHHERLELKPIDKSPDPNPIMTDTPIPRNSQDITPVDNSMDSN..IHQRRN.........SYRGH......ESEDSMS.......TLAGR...RGMRPK.MMMPFDSQP.PQPVISAHPIHSLDNPH......................HH.....FHSGSLAS...PTRSYLHHQVS....PWPVGTSMSHSDRANST..ESVRNTPSSDTMPASSSQPCAD.HQDPDS....SSGAYLGS.AQEEDAAQSLPTAHVRPSHPLKSFAVPAVPAAGS..AYDPTLPSTPLLTQQ.......APSHPVHSVKT..........ASIGTLGRTRPP.MPVVVPSAPDVQE..TTRMLEDS.ESSYEPDELTKEMAHLEGLMKDLNAITTA
A0A0R4IP15_DANRE/1135-1428             LKPPDLWIHHERLELKPIDKSPEPNPVMTDTPIPRTSQDITPVDGSMDP...MLQRRN.........SYRGH......ESEDSMS.......TLAGR...RGMRPK.MMMPFDAQP.PQPVISAHPIHSLDNHH......................HH.....YHLGSLAS...PTRSYLHHQSS....TRSIATPISHLDRAEST..ESVRNTPNAELLPPSGQPSCTTDLSETD.......ISFHSS.AAEEEPAFATPTAHVRPTHPLKSFAVPAIPAHAM..YDSAALPSTPLLSQT.......GP....HSVKT..........ASIGTLGRTRTP.MPVIVPNAPDVSE..GCRLHEDA.GSNYETDELSEEMAHLEGLMKDLNAITTA
W5NCR8_LEPOC/1145-1445                 LKPPDLWIHHERLELKPIDKSPEPNPVMTDTPIPRTSQDITPVDSAADNT..IHQRRS.........SCRGH......ESEDSMS.......TLAGR...RGMRPK.MMMPFDAQP.PQPVISAHPIHSLDNHH......................HH.....YHSGSLAS...PTRSHLHHQIN....PRPLATPISHVDRAHSA..ESVRNTPSADPLPVPVQPACAVDHPEPDS.....GASFLSS.APEEESYNP.PTAHVRPTHPLKSFAVPAVPTPGT.SFESPALPSTPLLTQT.......GPASQVHSVKT..........ASIGTLGRTRSP.MPVIVPSAPDVPE..TSKMLEDV.ESNYEADELSEEMAHLEGLMKDLNAITTA
H0X2Y4_OTOGA/1120-1417                 LRPPDLWIHHEEMEMKNIEKPSGTDPAGRDSPI.QSCQDLTPVSHSQSET.QLGSKST.........SHSGQ......DTEEAGSSMSTLERSLAAR...RATRAK.LMIPMDAQSSNPAVVSAIPVPTLESA.......................QY.......PGILPS...PTCGYPHPQFTLRPVPFP.TLSVDRGFGAGRS..QSVSEGPTTQQPPMLPPSQPEHP...................SSEEAPSRTIPTACVRPTHPLRSFANPLLPPPMS..AIEPKVPYTPLLSQP.......GPTLPKTHVKT..........ASLGLAGKARSPLLPVSVPTAPEVSEE.SHKPTEDS.ANVYEQDDLSEQMASLEGLMKQLNAITGS
W5L4H6_ASTMX/1133-1423                 LRPPDLWIHHEEMELKNIEKPSSSAPSGRESPI.QSCQEIAPVSHSQSES.QMGSKS..........SHSGG......DADEASSSISTLERSLAAR...RATRTK.MMIPMDSQPSNTPVVSAIPVPTLESS.......................QY.......PGILPS...PTCGYTPHTKF....TLR.PMPFSTLTVDRSY..GAAPLGP.QQQPTLIPTVQSEPS...................GSEEIPSRTIPTACVRPSHPMRSFTNPLLPPPMG..TIEPKV.YTPMMPQT.......GGSLPKPQVKT..........ASLGQAGKARSPLLPVSVPTAPETAEE.GQKPPEDP.ASVYEQDDLSEQMASLEGLMKQLNAITGS
G3Q2S1_GASAC/1097-1393                 LRPPDLWIHHEEMEMKNMEKAPSVAPSGHDSPL.QSCQDLPQVAHSQSES.HMGSKS..........SHSGA......DGDEASSSISTLDRSLAGR...RGTRGK.MMIPMDSQPSNTPVVSAIPVPAMDSS.......................QY.......PGILPS...PSCGFTHNKFSLRPMPFP.SLTVDRGYTPGYS..SSGGTGLAVQKVTSHLTSYQKHS................R..LISRPPATVIPTIVILLPHKILIFTDYLITPIKS..EIYPRD.FCQVEPAA.........SLSKPQVKT..........ASLGQAGKARSPLLPVSVPTAPDVSEEGGTKPAEDSAANIYEQDDLSEQMASLEGLMKQLNAITGS
H3D9L5_TETNG/1131-1421                 LRPPDLWIHHEEMEMKNMEKAPSVAPSGHDSPI.QSCQDLPQVAHSQSES.QIGSKS..........SHSGG......DGDEASSSISTLERSLAAR...RGTRSK.MMIPMDTQPSNTPVVSAIPVPALDSS.......................QY.......SGILPS...PSCGFTHNKFSLRPMPFS.TLTVDRGYTPVVS........PVPGAPAPVVPAPAE.....................EAQGAGGRSIPTACVRPTHPLRSFTNPLLPSSMG..TIDPKV.YTSMMPQS.....SSGASLPKPQVKT..........ASLGQPGKARSPLLPVSVPTAPDLTEE.AAKAAEDSAANVYEQDDLSEQMASLEGLMKQLNAITSS
#=GC seq_cons                          lKPPDLWIHHEcMELKslEKSspssPshp-SPlsposQ-Ls.susopsss.plts+Ss.........SYpGs......-o-EusS.......TLAuR...RuhRPK.hMlPhDSQP.sQPVlSAhPl.sh-sop......................QY.....hHsslLso...Posuah.........s.s.sh.hscussss.s..pShcpsPsssphshssospstss.................u.sspt-sspohPTu+lp.uHPLKSFoVPAlPPpuu.....st.PSTPh.ppp.......tPohstssVKT..........ASlGhhG+sRsP.hPVoVPoAP-ssEE.sp+h.Ess.pssYEsDELocEMAsLEGLMKDLNAITuS
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