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0  structures 1  species 0  interactions 1  sequence 1  architecture

Family: BDV_P24 (PF06595)

Summary: Borna disease virus P24 protein

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This is the Wikipedia entry entitled "Bornavirus". More...

Bornavirus Edit Wikipedia article

Bornavirus
Virus classification
Group: Group V ((-)ssRNA)
Order: Mononegavirales
Family: Bornaviridae
Genus: Bornavirus
Type Species

Bornavirus is a genus of viruses in the order Mononegavirales. Horses, sheep, cattle, rodents, birds, and humans serve as natural hosts. There are currently five species in this genus, and it is the only genus in its family (Bornaviridae). Diseases associated with this genus include: mammals borna disease : fatal neurologic disease, restricted to central Europe. birds: encephalitis, proventricular dilatation disease.[1][2]

Taxonomy

Group: ssRNA(-)

[2]

Structure

Viruses in Bornavirus are enveloped, with spherical geometries. The diameter is around 70 to 130 nm. Genomes are linear, around 8.9kb in length. The genome codes for 9 proteins. [1]

Genus Structure Symmetry Capsid Genomic Arrangement Genomic Segmentation
Bornavirus Spherical Enveloped Linear Monopartite

Life Cycle

Viral replication is nuclear. Entry into the host cell is achieved by attachment of the viral GP glycoproteins to host receptors, which mediates clathrin-mediated endocytosis. Replication follows the negative stranded RNA virus replication model. Negative stranded rna virus transcription, using polymerase stuttering, with some alternative splicing mechanism is the method of transcription. The virus exits the host cell by nuclear pore export. Horses, sheep, cattle, rodents, birds, and humans serve as the natural host. Transmission routes are fomite, contact, urine, feces, and saliva.[1]

Genus Host Details Tissue Tropism Entry Details Release Details Replication Site Assembly Site Transmission
Bornavirus Horses; sheep; cattle; rodents; birds; humans Neurons; astrocytes; oligodendrocytes; ependymal cells Clathrin-mediated endocytosis Budding Nucleus[3] Cytoplasm Fomites; contact: saliva; contact: urine; contact: feces

Pathogenicity

Between 2011 and 2013, three German breeders of variegated squirrels (Sciurus variegatoides) had encephalitis with similar clinical signs and died 2 to 4 months after onset of the clinical symptoms. Genomic analysis found a previously unknown bornavirus in a contact squirrel and in brain tissue from the three men, the researchers reported, and it is the "likely causative agent" in their deaths. Prior to this, Bornavirus species were not thought to be responsible for human diseases.[4][5]

References

  1. ^ a b c "Viral Zone". ExPASy. Retrieved 12 June 2015. 
  2. ^ a b ICTV. "Virus Taxonomy: 2014 Release". Retrieved 12 June 2015. 
  3. ^ Veterinary Microbiology and microbial disease, 2nd edition, P J Quinn et al. Wiley-Blackwell
  4. ^ A Variegated Squirrel Bornavirus Associated with Fatal Human Encephalitis
  5. ^ Zoonotic bornavirus from variegated squirrel tied to fatal CNS infections in German breeders.

External links

This page is based on a Wikipedia article. The text is available under the Creative Commons Attribution/Share-Alike License.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Borna disease virus P24 protein Provide feedback

This family consists of several Borna disease virus (BDV) P24 proteins. The function of this family is unknown.

This tab holds annotation information from the InterPro database.

InterPro entry IPR009517

Borna disease virus (BDV) is a non-cytolytic, neurotropic RNA virus that has a broad host range in warm-blooded animals. BDV is an enveloped virus, non-segmented, negative-stranded RNA genome and has an organisation characteristic of a member of Bornaviridae in the order of Mononegavirale. This family consists of several BDV P24 (phosphoprotein 24) proteins. They are essential components of the RNA polymerase transcription and replication complex.

P24 is encoded by open reading frame II (ORF-II) and undergoes high rates of mutation in humans. They bind amphoterin-HMGB1, a multifunctional protein, directly may cause deleterious effects in cellular functions by its interference with HMGB1 [PUBMED:14581561]. Horse and human P24 have no species-specific amino acid residues, suggesting that the two viruses related [PUBMED:8523585, PUBMED:9811743].

Numerous interactions of the immune system with the central nervous system have been described. Mood and psychotic disorders, such as severe depression and schizophrenia, are both heterogeneous disorders regarding clinical symptomatology, the acuity of symptoms, the clinical course and the treatment response [PUBMED:18623121]. BDV p24 RNA has been detected in the peripheral blood mononuclear cells (PBMCs) of psychiatric patients with such conditions [PUBMED:9811743]. Some studies find a significant difference in the prevalence of BDV p24 RNA in patients with mood disorders and schizophrenia [PUBMED:16324750], whilst others find no difference between patients and control groups [PUBMED:9811743]. Consequently, debate about the role of BDV in psychiatric diseases remains alive.

Domain organisation

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(105)
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(1)
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(136)
NCBI
(105)
Meta
(0)
RP15
(1)
RP35
(1)
RP55
(1)
RP75
(1)
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  Seed
(1)
Full
(1)
Representative proteomes UniProt
(136)
NCBI
(105)
Meta
(0)
RP15
(1)
RP35
(1)
RP55
(1)
RP75
(1)
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This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

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Curation and family details

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Seed source: Pfam-B_20092 (release 10.0)
Previous IDs: none
Type: Family
Author: Moxon SJ
Number in seed: 1
Number in full: 1
Average length of the domain: 201.00 aa
Average identity of full alignment: 100 %
Average coverage of the sequence by the domain: 100.00 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 11927849 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 25.0 25.0
Trusted cut-off 466.9 466.8
Noise cut-off 22.1 17.9
Model length: 201
Family (HMM) version: 8
Download: download the raw HMM for this family

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