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0  structures 7  species 0  interactions 7  sequences 1  architecture

Family: BDV_P24 (PF06595)

Summary: Borna disease virus P24 protein

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This is the Wikipedia entry entitled "Bornavirus". More...

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Borna disease virus P24 protein Provide feedback

This family consists of several Borna disease virus (BDV) P24 proteins. The function of this family is unknown.

This tab holds annotation information from the InterPro database.

InterPro entry IPR009517

Borna disease virus (BDV) is a non-cytolytic, neurotropic RNA virus that has a broad host range in warm-blooded animals. BDV is an enveloped virus, non-segmented, negative-stranded RNA genome and has an organisation characteristic of a member of Bornaviridae in the order of Mononegavirale. This family consists of several BDV P24 (phosphoprotein 24) proteins. They are essential components of the RNA polymerase transcription and replication complex.

P24 is encoded by open reading frame II (ORF-II) and undergoes high rates of mutation in humans. They bind amphoterin-HMGB1, a multifunctional protein, directly may cause deleterious effects in cellular functions by its interference with HMGB1 [PUBMED:14581561]. Horse and human P24 have no species-specific amino acid residues, suggesting that the two viruses related [PUBMED:8523585, PUBMED:9811743].

Numerous interactions of the immune system with the central nervous system have been described. Mood and psychotic disorders, such as severe depression and schizophrenia, are both heterogeneous disorders regarding clinical symptomatology, the acuity of symptoms, the clinical course and the treatment response [PUBMED:18623121]. BDV p24 RNA has been detected in the peripheral blood mononuclear cells (PBMCs) of psychiatric patients with such conditions [PUBMED:9811743]. Some studies find a significant difference in the prevalence of BDV p24 RNA in patients with mood disorders and schizophrenia [PUBMED:16324750], whilst others find no difference between patients and control groups [PUBMED:9811743]. Consequently, debate about the role of BDV in psychiatric diseases remains alive.

Domain organisation

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Alignments

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We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(1)
Full
(7)
Representative proteomes UniProt
(149)
NCBI
(118)
Meta
(0)
RP15
(6)
RP35
(6)
RP55
(6)
RP75
(6)
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1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

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  Seed
(1)
Full
(7)
Representative proteomes UniProt
(149)
NCBI
(118)
Meta
(0)
RP15
(6)
RP35
(6)
RP55
(6)
RP75
(6)
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  Seed
(1)
Full
(7)
Representative proteomes UniProt
(149)
NCBI
(118)
Meta
(0)
RP15
(6)
RP35
(6)
RP55
(6)
RP75
(6)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download   Download    
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You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

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Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

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Curation and family details

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Curation View help on the curation process

Seed source: Pfam-B_20092 (release 10.0)
Previous IDs: none
Type: Family
Sequence Ontology: SO:0100021
Author: Moxon SJ
Number in seed: 1
Number in full: 7
Average length of the domain: 202.40 aa
Average identity of full alignment: 64 %
Average coverage of the sequence by the domain: 100.00 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 45638612 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 25.0 25.0
Trusted cut-off 146.6 146.5
Noise cut-off 23.6 22.8
Model length: 201
Family (HMM) version: 11
Download: download the raw HMM for this family

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