Summary: D-glucuronyl C5-epimerase C-terminus
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D-glucuronyl C5-epimerase C-terminus Provide feedback
This family represents the C-terminus of D-glucuronyl C5-epimerase ( EC:5.1.3.-). Glucuronyl C5-epimerases catalyse the conversion of D-glucuronic acid (GlcUA) to L-iduronic acid (IdceA) units during the biosynthesis of glycosaminoglycans .
Li J, Hagner-McWhirter A, Kjellen L, Palgi J, Jalkanen M, Lindahl U; , J Biol Chem 1997;272:28158-28163.: Biosynthesis of heparin/heparan sulfate. cDNA cloning and expression of D-glucuronyl C5-epimerase from bovine lung. PUBMED:9346972 EPMC:9346972
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR010598
This entry consists of known or predicted D-glucuronyl C5-epimerases which share a common C-terminal region. Glucuronyl C5-epimerases catalyse the conversion of D-glucuronic acid (GlcUA) to L-iduronic acid (IdceA) units during the biosynthesis of glycosaminoglycans [PUBMED:9346972].
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
|Cellular component||integral to membrane (GO:0016021)|
|Molecular function||racemase and epimerase activity, acting on carbohydrates and derivatives (GO:0016857)|
|Biological process||glycosaminoglycan biosynthetic process (GO:0006024)|
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This Clan includes CAZy clans GH-L, GH-M and GH-G. The members of this clan share a common structure composed of 6 helical hairpins. Most members of this superfamily are glycosyl hydrolase enzymes.
The clan contains the following 28 members:A2M_comp Bac_rhamnosid C5-epim_C Cobalamin_bind DUF1237 DUF1680 DUF2807 DUF4097 DUF4098 DUF608 GDE_C GlcNAc_2-epim Glyco_hydro_100 Glyco_hydro_15 Glyco_hydro_47 Glyco_hydro_48 Glyco_hydro_63 Glyco_hydro_65m Glyco_hydro_76 Glyco_hydro_8 Glyco_hydro_88 Glyco_hydro_9 Glycoamylase Pec_lyase Prenyltrans Prenyltrans_1 Prenyltrans_2 Trehalase
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Curation and family details
|Seed source:||Pfam-B_16571 (release 10.0)|
|Author:||Vella Briffa B|
|Number in seed:||18|
|Number in full:||182|
|Average length of the domain:||180.00 aa|
|Average identity of full alignment:||42 %|
|Average coverage of the sequence by the domain:||36.94 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||8|
|Download:||download the raw HMM for this family|
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