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This family represents a conserved region within viral UL97 phosphotransferases. UL97 participates in the phosphorylation of the nucleoside analog ganciclovir (GCV) to produce GCV-monophosphate .
Rawlinson WD, Zeng F, Farrell HE, Cunningham AL, Scalzo AA, Booth TW, Scott GM; , Virology 1997;233:358-363.: The murine cytomegalovirus (MCMV) homolog of the HCMV phosphotransferase (UL97(pk)) gene. PUBMED:9217058 EPMC:9217058
This tab holds annotation information from the InterPro database.
InterPro entry IPR010615
The gene product form the gene UL97 is a serine/threonine kinase. Although it can phosphorylates the antiviral drug ganciclovir [PUBMED:9217058], its biological function is the phosphorylation of its natural viral and cellular protein substrates which affect viral replication at many levels.
The kinase phosphorylates eukaryotic elongation factor 1delta, the carboxyl terminal domain of the large subunit of RNA polymerase II, the retinoblastoma tumour suppressor and lamins A and C performing a similar function to the cdc2/cyclin-dependent kinase 1. The activity of UL97 appear to stimulate the cell cycle to support viral DNA synthesis, enhance the expression of viral genes, promote virion morphogenesis and facilitate the egress of mature capsids from the nucleus [PUBMED:19434630].
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
|Molecular function||ATP binding (GO:0005524)|
|protein kinase activity (GO:0004672)|
|Biological process||viral process (GO:0016032)|
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This superfamily includes the Serine/Threonine- and Tyrosine- protein kinases as well as related kinases that act on non-protein substrates.
The clan contains the following 35 members:ABC1 AceK Act-Frag_cataly Alpha_kinase APH APH_6_hur Choline_kinase CotH DUF1679 DUF2252 DUF4135 EcKinase Fam20C Fructosamin_kin FTA2 Haspin_kinase HipA_C Ins_P5_2-kin IPK IucA_IucC Kdo Kinase-like KIND PI3_PI4_kinase PIP49_C PIP5K Pkinase Pkinase_Tyr Pox_ser-thr_kin RIO1 Seadorna_VP7 UL97 WaaY YrbL-PhoP_reg YukC
We make a range of alignments for each Pfam-A family:
- the curated alignment from which the HMM for the family is built
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- Representative Proteomes (RPs) at 15%, 35%, 55% and 75% co-membership thresholds
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Curation and family details
|Seed source:||Pfam-B_1747 (release 10.0)|
|Author:||Vella Briffa B|
|Number in seed:||2|
|Number in full:||3|
|Average length of the domain:||180.70 aa|
|Average identity of full alignment:||49 %|
|Average coverage of the sequence by the domain:||29.59 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 26740544 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||11|
|Download:||download the raw HMM for this family|
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