Summary: Sif protein
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This family consists of several SifA and SifB and SseJ proteins which seem to be specific to the Salmonella species. SifA, SifB and SseJ have been demonstrated to localise to the Salmonella-containing vacuole (SCV) and to Salmonella-induced filaments (Sifs). Trafficking of SseJ and SifB away from the SCV requires the SPI-2 effector SifA. SseJ trafficking away from the SCV along Sifs is unnecessary for its virulence function .
Freeman JA, Ohl ME, Miller SI; , Infect Immun 2003;71:418-427.: The Salmonella enterica serovar typhimurium translocated effectors SseJ and SifB are targeted to the Salmonella-containing vacuole. PUBMED:12496192 EPMC:12496192
This tab holds annotation information from the InterPro database.
InterPro entry IPR010637
This family consists of several SifA and SifB and SseJ proteins, which seem to be specific to the Salmonella species. They are effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. SifA, SifB and SseJ have been demonstrated to localise to the Salmonella-containing vacuole (SCV) and to Salmonella-induced filaments (Sifs). Trafficking of SseJ and SifB away from the SCV requires the SPI-2 effector SifA. SseJ trafficking away from the SCV along Sifs is unnecessary for its virulence function [PUBMED:12496192].
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Curation and family details
|Seed source:||Pfam-B_7884 (release 10.0)|
|Number in seed:||4|
|Number in full:||15|
|Average length of the domain:||203.60 aa|
|Average identity of full alignment:||28 %|
|Average coverage of the sequence by the domain:||73.91 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 26740544 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||10|
|Download:||download the raw HMM for this family|
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Sif domain has been found. There are 2 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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