Summary: Invasion associated locus B (IalB) protein
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Invasion associated locus B (IalB) protein Provide feedback
This family consists of several invasion associated locus B (IalB) proteins and related sequences. IalB is known to be a major virulence factor in Bartonella bacilliformis where it was shown to have a direct role in human erythrocyte parasitism. IalB is upregulated in response to environmental cues signaling vector-to-host transmission. Such environmental cues would include, but not be limited to, temperature, pH, oxidative stress, and haemin limitation. It is also thought that IalB would aide B. bacilliformis survival under stress-inducing environmental conditions . The role of this protein in other bacterial species is unknown.
Coleman SA, Minnick MF; , Microb Pathog 2003;34:179-186.: Differential expression of the invasion-associated locus B (ialB) gene of Bartonella bacilliformis in response to environmental cues. PUBMED:12668141 EPMC:12668141
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR010642
This family consists of several invasion associated locus B (IalB) proteins and related sequences. IalB is known to be a major virulence factor in Bartonella bacilliformis where it was shown to have a direct role in human erythrocyte parasitism. IalB is up-regulated in response to environmental cues signalling vector-to-host transmission. Such environmental cues would include, but not be limited to, temperature, pH, oxidative stress, and haemin limitation. It is also thought that IalB would aide B. bacilliformis survival under stress-inducing environmental conditions [PUBMED:12668141]. The role of this protein in other bacterial species is unknown.
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Curation and family details
|Seed source:||Pfam-B_3703 (release 10.0)|
|Number in seed:||84|
|Number in full:||752|
|Average length of the domain:||127.70 aa|
|Average identity of full alignment:||25 %|
|Average coverage of the sequence by the domain:||66.93 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||7|
|Download:||download the raw HMM for this family|
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the IalB domain has been found. There are 12 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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