Summary: Uncharacterised MFS-type transporter YbfB
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Uncharacterised MFS-type transporter YbfB Provide feedback
This family represents putative bacterial membrane proteins which may be sugar transporters. Members carry twelve transmembrane regions which are characteristic of members of the major facilitator sugar-transporter superfamily.
Internal database links
|SCOOP:||DUF1774 ATG22 P5-ATPase MFS_1_like Nterm_IS4|
|Similarity to PfamA using HHSearch:||MFS_1 MFS_1 MFS_2|
External database links
- the number of sequences which exhibit this architecture
a textual description of the architecture, e.g. Gla, EGF x 2, Trypsin.
This example describes an architecture with one
Gladomain, followed by two consecutive
EGFdomains, and finally a single
- the UniProt description of the protein sequence
- the number of residues in the sequence
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The major facilitator superfamily (MFS) is one of the two largest families of membrane transporters found on Earth . It is present ubiquitously in bacteria, archaea, and eukarya and includes members that can function by solute uniport, solute/cation symport, solute/cation antiport and/or solute/solute antiport with inwardly and/or outwardly directed polarity . All permeases of the MFS possess either 12 or 14 transmembrane helices .
The clan contains the following 24 members:Acatn ATG22 BT1 Folate_carrier FPN1 FTR1 LacY_symp MFS_1 MFS_1_like MFS_2 MFS_3 MFS_4 MFS_5 MFS_Mycoplasma Nodulin-like Nuc_H_symport Nucleoside_tran OATP PTR2 PUCC Sugar_tr TLC TRI12 UNC-93
We make a range of alignments for each Pfam-A family:
- the curated alignment from which the HMM for the family is built
- the alignment generated by searching the sequence database using the HMM
- Representative Proteomes (RPs) at 15%, 35%, 55% and 75% co-membership thresholds
- alignment generated by searching the NCBI sequence database using the family HMM
- alignment generated by searching the metagenomics sequence database using the family HMM
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1Cannot generate PP/Heatmap alignments for seeds; no PP data available
Key: available, not generated, — not available.
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Curation and family details
|Seed source:||Pfam-B_5646 (release 10.0)|
|Author:||Vella Briffa B|
|Number in seed:||11|
|Number in full:||5964|
|Average length of the domain:||343.70 aa|
|Average identity of full alignment:||38 %|
|Average coverage of the sequence by the domain:||91.46 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 80369284 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||10|
|Download:||download the raw HMM for this family|
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