Summary: BALF1 protein
BALF1 protein Provide feedback
This family consists of several BALF1 proteins which seem to be specific to the Lymphocryptoviruses. BALF1, inhibits the antiapoptotic activity of EBV BHRF1 and of KSBcl-2 .
Bellows DS, Howell M, Pearson C, Hazlewood SA, Hardwick JM; , J Virol 2002;76:2469-2479.: Epstein-Barr virus BALF1 is a BCL-2-like antagonist of the herpesvirus antiapoptotic BCL-2 proteins. PUBMED:11836425 EPMC:11836425
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This tab holds annotation information from the InterPro database.
InterPro entry IPR010677
Epstein-Barr virus (strain GD1) (HHV-4), a human tumour DNA virus and a prominent member of gamma-herpesviruses, encodes homologues of cellular antiapoptotic viral Bcl-2 proteins BALF1 and BHRF1. They protect the virus from apoptosis in its host cell during virus synthesis [PUBMED:16277553, PUBMED:16087121]. The virus infects B lymphocytes to establish a latent infection and yield proliferating, growth-transformed B cells in vitro. Bcl-2 genes are essential for the initial evasion of apoptosis which allows it to establish a latent infection or cause cellular transformation, or both [PUBMED:16277553].
Bcl-2 family proteins can inhibit or induce programmed cell death in part by counteracting the activity of other BCL-2 family members. BALF1, inhibits the antiapoptotic activity of EBV BHRF1 and of KSBcl-2 in several transfected cell lines. BALF1 fails, however, to inhibit the cellular BCL-2 family member, BCL-x(L). Thus, BALF1 acts as a negative regulator of the survival function of BHRF1, similar to the counterbalance observed between cellular BCL-2 family members [PUBMED:11836425].
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Curation and family details
|Seed source:||Pfam-B_12069 (release 10.0)|
|Number in seed:||2|
|Number in full:||16|
|Average length of the domain:||171.80 aa|
|Average identity of full alignment:||39 %|
|Average coverage of the sequence by the domain:||88.56 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||6|
|Download:||download the raw HMM for this family|
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