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40  structures 5735  species 0  interactions 8380  sequences 31  architectures

Family: BATS (PF06968)

Summary: Biotin and Thiamin Synthesis associated domain

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

The Pfam group coordinates the annotation of Pfam families in Wikipedia, but we have not yet assigned a Wikipedia article to this family. If you think that a particular Wikipedia article provides good annotation, please let us know.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Biotin and Thiamin Synthesis associated domain Provide feedback

Biotin synthase (BioB), EC:2.8.1.6 , catalyses the last step of the biotin biosynthetic pathway. The reaction consists in the introduction of a sulphur atom into dethiobiotin. BioB functions as a homodimer [1]. Thiamin synthesis if a complex process involving at least six gene products (ThiFSGH, ThiI and ThiJ). Two of the proteins required for the biosynthesis of the thiazole moiety of thiamine (vitamin B(1)) are ThiG and ThiH (this family) and form a [2]. Both of these reactions are thought of involve the binding of co-factors, and both function as dimers [1,2]. This domain therefore may be involved in co-factor binding or dimerisation (Finn, RD personal observation).

Literature references

  1. Ollagnier-de-Choudens S, Mulliez E, Fontecave M; , FEBS Lett 2002;532:465-468.: The PLP-dependent biotin synthase from Escherichia coli: mechanistic studies. PUBMED:12482614 EPMC:12482614

  2. Leonardi R, Fairhurst SA, Kriek M, Lowe DJ, Roach PL; , FEBS Lett 2003;539:95-99.: Thiamine biosynthesis in Escherichia coli: isolation and initial characterisation of the ThiGH complex. PUBMED:12650933 EPMC:12650933


This tab holds annotation information from the InterPro database.

InterPro entry IPR010722

This domain is found in biotin synthase and 2-iminoacetate synthase. The latter enzyme is involved in thiamine diphosphate biosynthesis. The reactions catalysed by these enzymes involve the binding of co-factors and both enzymes function as dimers [ PUBMED:12482614 , PUBMED:12650933 ]. This domain may therefore be involved in co-factor binding or dimerisation. The domain is also found in proteins that are currently uncharacterised, such as SWISSPROT .

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(680)
Full
(8380)
Representative proteomes UniProt
(38608)
RP15
(1294)
RP35
(4217)
RP55
(8374)
RP75
(14733)
Jalview View  View  View  View  View  View  View 
HTML View             
PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(680)
Full
(8380)
Representative proteomes UniProt
(38608)
RP15
(1294)
RP35
(4217)
RP55
(8374)
RP75
(14733)
Alignment:
Format:
Order:
Sequence:
Gaps:
Download/view:

Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(680)
Full
(8380)
Representative proteomes UniProt
(38608)
RP15
(1294)
RP35
(4217)
RP55
(8374)
RP75
(14733)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Pfam-B_5417 (release 10.0)
Previous IDs: none
Type: Domain
Sequence Ontology: SO:0000417
Author: Finn RD
Number in seed: 680
Number in full: 8380
Average length of the domain: 95.7 aa
Average identity of full alignment: 31 %
Average coverage of the sequence by the domain: 25.93 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 22.2 22.2
Trusted cut-off 22.2 22.2
Noise cut-off 22.1 22.1
Model length: 86
Family (HMM) version: 16
Download: download the raw HMM for this family

Species distribution

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Archea Archea Eukaryota Eukaryota
Bacteria Bacteria Other sequences Other sequences
Viruses Viruses Unclassified Unclassified
Viroids Viroids Unclassified sequence Unclassified sequence

Selections

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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the BATS domain has been found. There are 40 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A077ZHA3 View 3D Structure Click here
A0A0D2GW88 View 3D Structure Click here
A0A0H3GK97 View 3D Structure Click here
A0A0H3GKM3 View 3D Structure Click here
A0A175W702 View 3D Structure Click here
A0A1C1CC09 View 3D Structure Click here
A0A1D6KKP7 View 3D Structure Click here
A0A1D6M1W1 View 3D Structure Click here
A0A1D8PS33 View 3D Structure Click here
A0JTA3 View 3D Structure Click here
A0KIC6 View 3D Structure Click here
A0L3M0 View 3D Structure Click here
A0LJA8 View 3D Structure Click here
A0LTP8 View 3D Structure Click here
A0PYU9 View 3D Structure Click here
A0QX70 View 3D Structure Click here
A0RW96 View 3D Structure Click here
A1AN77 View 3D Structure Click here
A1AWE7 View 3D Structure Click here
A1B1Z0 View 3D Structure Click here
A1B656 View 3D Structure Click here
A1BCQ5 View 3D Structure Click here
A1K9C8 View 3D Structure Click here
A1R3R7 View 3D Structure Click here
A1S5I9 View 3D Structure Click here
A1SM80 View 3D Structure Click here
A1SW31 View 3D Structure Click here
A1T8V0 View 3D Structure Click here
A1TQ53 View 3D Structure Click here
A1UHL9 View 3D Structure Click here
A1VUJ4 View 3D Structure Click here
A1W7J6 View 3D Structure Click here
A1WVM7 View 3D Structure Click here
A2SGQ6 View 3D Structure Click here
A3DBD3 View 3D Structure Click here
A3MYI9 View 3D Structure Click here
A3PDJ8 View 3D Structure Click here
A3QDN8 View 3D Structure Click here
A4FIS6 View 3D Structure Click here
A4G1F1 View 3D Structure Click here