Summary: EthD domain
EthD domain Provide feedback
This family consists of several bacterial sequences which are related to the EthD protein of Rhodococcus ruber (Q93EX2). In Rhodococcus ruber, EthD is thought to be involved in the degradation of ethyl tert-butyl ether (ETBE). EthD synthesis is induced by ETBE but it's exact function is unknown, it is however thought to be essential to the ETBE degradation system.
Chauvaux S, Chevalier F, Le Dantec C, Fayolle F, Miras I, Kunst F, Beguin P; , J Bacteriol 2001;183:6551-6557.: Cloning of a genetically unstable cytochrome P-450 gene cluster involved in degradation of the pollutant ethyl tert-butyl ether by Rhodococcus ruber. PUBMED:11673424 EPMC:11673424
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR009799
This domain is found in several bacterial sequences which are related to the EthD (Ethyl tert-butyl ether degradation) protein of Rhodococcus ruber SWISSPROT. In Rhodococcus ruber, EthD is thought to be involved in the degradation of ethyl tert-butyl ether (ETBE) [PUBMED:11673424]. EthD synthesis is induced by ETBE but its exact function is unknown. It is however thought to be essential to the ETBE degradation system.
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a textual description of the architecture, e.g. Gla, EGF x 2, Trypsin.
This example describes an architecture with one
Gladomain, followed by two consecutive
EGFdomains, and finally a single
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This superfamily of proteins possess a Ferredoxin-like fold. Pairs of these assemble into a beta barrel. The function of this barrel is quite varied and includes Muconolactone isomerase as well as monooxygenases.
The clan contains the following 18 members:ABM AsnC_trans_reg Chlor_dismutase Dabb Dehydratase_hem DUF1330 DUF3291 DUF4188 DUF718 DUF881 Dyp_perox EthD MIase MmlI NapD NIPSNAP SOR YCII
We make a range of alignments for each Pfam-A family:
- the curated alignment from which the HMM for the family is built
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- Representative Proteomes (RPs) at 15%, 35%, 55% and 75% co-membership thresholds
- alignment generated by searching the NCBI sequence database using the family HMM
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Curation and family details
|Seed source:||Pfam-B_15539 (release 10.0)|
|Author:||Moxon SJ, Bateman A|
|Number in seed:||57|
|Number in full:||827|
|Average length of the domain:||86.60 aa|
|Average identity of full alignment:||19 %|
|Average coverage of the sequence by the domain:||56.80 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||6|
|Download:||download the raw HMM for this family|
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There is 1 interaction for this family. More...
We determine these interactions using iPfam, which considers the interactions between residues in three-dimensional protein structures and maps those interactions back to Pfam families. You can find more information about the iPfam algorithm in the journal article that accompanies the website.
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the EthD domain has been found. There are 4 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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