Summary: Sexual stage antigen s48/45 domain
Sexual stage antigen s48/45 domain Provide feedback
This family contains sexual stage s48/45 antigens from Plasmodium (approximately 450 residues long). These are surface proteins expressed by Plasmodium male and female gametes that have been shown to play a conserved and important role in fertilisation . This domain contains 6 conserved cysteines suggesting 3 disulphide bridges.
van Dijk MR, Janse CJ, Thompson J, Waters AP, Braks JA, Dodemont HJ, Stunnenberg HG, van Gemert GJ, Sauerwein RW, Eling W; , Cell 2001;104:153-164.: A central role for P48/45 in malaria parasite male gamete fertility. PUBMED:11163248 EPMC:11163248
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR010884
This family contains sexual stage s48/45 antigens from Plasmodium (approximately 450 residues long). These are surface proteins expressed by Plasmodium male and female gametes that have been shown to play a conserved and important role in fertilisation [PUBMED:11163248].
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Curation and family details
|Seed source:||Pfam-B_21037 (release 10.0) and Pfam-B_4621 (release 14.0)|
|Author:||Vella Briffa B, Bateman A|
|Number in seed:||92|
|Number in full:||1566|
|Average length of the domain:||122.50 aa|
|Average identity of full alignment:||22 %|
|Average coverage of the sequence by the domain:||33.52 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 80369284 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||9|
|Download:||download the raw HMM for this family|
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There is 1 interaction for this family. More...
We determine these interactions using iPfam, which considers the interactions between residues in three-dimensional protein structures and maps those interactions back to Pfam families. You can find more information about the iPfam algorithm in the journal article that accompanies the website.
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the s48_45 domain has been found. There are 3 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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