Summary: HepA-related protein (HARP)
HepA-related protein (HARP) Provide feedback
This family represents a conserved region approximately 60 residues long within eukaryotic HepA-related protein (HARP). This exhibits single-stranded DNA-dependent ATPase activity, and is ubiquitously expressed in human and mouse tissues . Family members may contain more than one copy of this region.
Coleman MA, Eisen JA, Mohrenweiser HW; , Genomics 2000;65:274-282.: Cloning and characterization of HARP/SMARCAL1: a prokaryotic HepA-related SNF2 helicase protein from human and mouse. PUBMED:10857751 EPMC:10857751
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR010003
This entry represents a conserved region approximately 60 residues long within eukaryotic HepA-related protein (HARP). This exhibits single-stranded DNA-dependent ATPase activity, and is ubiquitously expressed in human and mouse tissues [PUBMED:10857751]. Family members may contain more than one copy of this region.
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
|Cellular component||nucleus (GO:0005634)|
|Molecular function||ATP binding (GO:0005524)|
|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides (GO:0016818)|
|helicase activity (GO:0004386)|
|Biological process||chromatin modification (GO:0016568)|
- the number of sequences which exhibit this architecture
a textual description of the architecture, e.g. Gla, EGF x 2, Trypsin.
This example describes an architecture with one
Gladomain, followed by two consecutive
EGFdomains, and finally a single
- the UniProt description of the protein sequence
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We make a range of alignments for each Pfam-A family:
- the curated alignment from which the HMM for the family is built
- the alignment generated by searching the sequence database using the HMM
- Representative Proteomes (RPs) at 15%, 35%, 55% and 75% co-membership thresholds
- alignment generated by searching the NCBI sequence database using the family HMM
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Curation and family details
|Seed source:||Pfam-B_21761 (release 10.0)|
|Author:||Vella Briffa B|
|Number in seed:||15|
|Number in full:||154|
|Average length of the domain:||54.50 aa|
|Average identity of full alignment:||44 %|
|Average coverage of the sequence by the domain:||11.43 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||8|
|Download:||download the raw HMM for this family|
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