Summary: Spasmodic peptide gm9a
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This family consists of several spasmodic peptide gm9a sequences. Conotoxin gm9a is a putative 27-residue polypeptide encoded by Conus gloriamaris and is known to be a homologue of the "spasmodic peptide", tx9a, isolated from the venom of the mollusk-hunting cone shell Conus textile . Upon injection of this venom component, normal mice are converted into behavioural phenocopies of a well-known mutant, the spasmodic mouse .
Miles LA, Dy CY, Nielsen J, Barnham KJ, Hinds MG, Olivera BM, Bulaj G, Norton RS; , J Biol Chem 2002;277:43033-43040.: Structure of a novel P-superfamily spasmodic conotoxin reveals an inhibitory cystine knot motif. PUBMED:12193600 EPMC:12193600
Lirazan MB, Hooper D, Corpuz GP, Ramilo CA, Bandyopadhyay P, Cruz LJ, Olivera BM; , Biochemistry 2000;39:1583-1588.: The spasmodic peptide defines a new conotoxin superfamily. PUBMED:10677206 EPMC:10677206
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR010012
This family consists of several spasmodic peptide gm9a sequences. Conotoxin gm9a is a putative 27-residue polypeptide encoded by Conus gloriamaris and is known to be a homologue of the 'spasmodic peptide', tx9a, isolated from the venom of the mollusk-hunting cone shell Conus textile [PUBMED:12193600]. Upon injection of this venom component, normal mice are converted into behavioural phenocopies of a well-known mutant, the spasmodic mouse [PUBMED:10677206].
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
|Cellular component||extracellular region (GO:0005576)|
|Biological process||pathogenesis (GO:0009405)|
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This clan contains a set of related small protein toxins and what appears to be the functionally distinct Albumin I domain. All members of this clan have a knottin-like fold. Additional information about this clan may be found from .
The clan contains the following 19 members:Agouti Albumin_I Conotoxin Mu-conotoxin Omega-toxin Tachystatin_B Toxin_11 Toxin_12 Toxin_16 Toxin_18 Toxin_21 Toxin_22 Toxin_23 Toxin_24 Toxin_27 Toxin_30 Toxin_7 Toxin_9 UPF0506
We make a range of alignments for each Pfam-A family:
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Curation and family details
|Seed source:||Pfam-B_90829 (release 10.0)|
|Number in seed:||2|
|Number in full:||4|
|Average length of the domain:||27.50 aa|
|Average identity of full alignment:||46 %|
|Average coverage of the sequence by the domain:||37.54 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||6|
|Download:||download the raw HMM for this family|
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Toxin_11 domain has been found. There are 1 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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