# STOCKHOLM 1.0
#=GF ID   Band_3_cyto
#=GF AC   PF07565.14
#=GF DE   Band 3 cytoplasmic domain
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF SE   Pfam-B_1004 (release 3.0)
#=GF GA   34.30 34.30;
#=GF TC   34.40 34.30;
#=GF NC   34.10 34.20;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF WK   Bicarbonate_transporter_proteins
#=GF RN   [1]
#=GF RM   11049968
#=GF RT   Crystallographic structure and functional interpretation of the
#=GF RT   cytoplasmic domain of erythrocyte membrane band 3. 
#=GF RA   Zhang D, Kiyatkin A, Bolin JT, Low PS; 
#=GF RL   Blood 2000;96:2925-2933.
#=GF DR   INTERPRO; IPR013769;
#=GF DR   SCOP; 1hyn; fa;
#=GF DR   TC; 2.A.31;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This family contains the cytoplasmic domain of the Band 3 anion
#=GF CC   exchange proteins that exchange Cl-/HCO3-. Band 3 constitutes
#=GF CC   the most abundant polypeptide in the red blood cell membrane,
#=GF CC   comprising 25% of the total membrane protein. The cytoplasmic
#=GF CC   domain of band 3 functions primarily as an anchoring site for
#=GF CC   other membrane-associated proteins. Included among the protein
#=GF CC   ligands of cdb3 are ankyrin, protein 4.2, protein 4.1,
#=GF CC   glyceraldehyde-3-phosphate dehydrogenase (GAPDH),
#=GF CC   phosphofructokinase, aldolase, hemoglobin, hemichromes, and the
#=GF CC   protein tyrosine kinase (p72syk). [1]
#=GF SQ   16
#=GS Q29N79_DROPS/170-438  AC Q29N79.3
#=GS G5EC65_CAEEL/67-345   AC G5EC65.1
#=GS S4A5_HUMAN/141-408    AC Q9BY07.2
#=GS Q2LZ95_DROPS/294-628  AC Q2LZ95.2
#=GS Q7PT77_ANOGA/85-347   AC Q7PT77.4
#=GS Q17LT4_AEDAE/264-527  AC Q17LT4.1
#=GS B3A3_RABIT/351-620    AC O18917.1
#=GS B3A2_HUMAN/352-620    AC P04920.4
#=GS B3AT_CHICK/89-336     AC P15575.1
#=GS B3AT_MOUSE/100-342    AC P04919.1
#=GS Q2Z1P9_HORSE/106-345  AC Q2Z1P9.1
#=GS Q9TUQ0_BOVIN/21-268   AC Q9TUQ0.1
#=GS B3AT_HUMAN/86-329     AC P02730.3
#=GS B3AT_HUMAN/86-329     DR PDB; 4KY9 P; 86-329;
#=GS B3AT_HUMAN/86-329     DR PDB; 1HYN S; 86-329;
#=GS B3AT_HUMAN/86-329     DR PDB; 1HYN R; 86-329;
#=GS B3AT_HUMAN/86-329     DR PDB; 4KY9 A; 86-329;
#=GS B3AT_HUMAN/86-329     DR PDB; 1HYN Q; 86-329;
#=GS B3AT_HUMAN/86-329     DR PDB; 1HYN P; 86-329;
#=GS Q1A708_STRPU/152-465  AC Q1A708.1
#=GS S4A8_HUMAN/145-404    AC Q2Y0W8.1
#=GS S4A8_HUMAN/145-404    DR PDB; 5JHO B; 92-344;
#=GS S4A8_HUMAN/145-404    DR PDB; 5JHO A; 92-344;
#=GS H3DGF3_TETNG/144-400  AC H3DGF3.1
Q29N79_DROPS/170-438             DVEEGGNRWSKPHVATLSLHSLFELRRLLVNGTVMLDMEAPNLEVMADLVCDQMVSAGTLPPGVKDKVKDALLRRHRHQHE........YAKKTRLPIIRSLADMRNHSSSKKK............................KSNSKNLRPTQNLPVITEDMVKSPSSQSMARPS.....................................................................SGTELNDQQHKGNTHFMRKIPPGAEASNILVGEVDFLERTLSCFIRLSQAAL....MGDLTEVPVPTRFIFILLGP.PGSQSNFHEIGRAMATLMSDEIFHEVAYRARKREHLLAGVDEFLDAVTVLPPGEWDPT
G5EC65_CAEEL/67-345              DVEQGGNRWSKPHVATLSLHSLFQLRSCIMNGHFMNDLAETDIPSIFNAVIENLEKSGDLPSENREELREILLRKHVHQYEQAKKNGAGGEKGGFLSTVRSISDIGKSFSHGKNL..........................SKIEEKPEGPVTSQTAGAPSGSSNQLTLPTVESV.....................................................................PKDISSEESSKGNLHFLKKLPAGVEASNVLIGEVDFLTRHICCFIRLKNANQ....LGDLTEVPVPTRFIFLLLGP.TGHGQQYREIGRAIATLMADEIFHDVAYGARDVDDLLDGIDEFLDQVTVLPPGEWDPN
S4A5_HUMAN/141-408               KVEEGGERWSKPHVSTLSLHSLFELRTCLQTGTVLLDLDSGSLPQIIDDVIEKQIEDGLLRPELRERVSYVLLRRHRHQTK..............KPIHRSLADIGKSVSTTNRSPARS.................PGAGPSLHHSTEDLRMRQSANYGRLCHAQSRSMNDI...........................................................................SLTPNTDQRKNKFMKKIPKDSEASNVLVGEVDFLDQPFIAFVRLIQSAM....LGGVTEVPVPTRFLFILLGP.SGRAKSYNEIGRAIATLMVDDLFSDVAYKARNREDLIAGIDEFLDEVIVLPPGEWDPN
Q2LZ95_DROPS/294-628             DVEEGSDRWGKPHVASLSFHSLLNLRRCLETGVVLLDLNEKDLPAVAYRVVEQMVIEDLIDINDKPSVMRSLLLRHRHVNE.........HQGVLPFTKRKYNSYTSLQFLWM..............................GADAQQQSLQQQQTRNLAKARRSICVTSSAPPAAAAAATTLNVGSPAGIASSIDHRRHSTMSYLGNLSGGTDDKKIKIMPAADIGGSKRSNELKIDMKDDMYSSSQEDLKKLQNDTILRRIPAGAEATTVLVGAVEFLDQPTIAFVRLSEGVM....MPTLTEVPVPVRFMFVLLGP.RNFDLDYHEVGRSISTLMANEHFHAIAYKADDRKDLLSAINEFLDDSIVLPPGNWDRH
Q7PT77_ANOGA/85-347              NLEEEADRWGRPHVAALSFHSLLNLRHCLETGVVLMSLEANDLSIVAHRVVEQMVARELIHEDDKPVIARALLLRHRHVNE.......NTHGGIFYGSRRRLSSFTSIRSVKN..............................DSRKPRIIPVVEINGH.GGQSEMRLNINDESY.....................................................................TSSQEDI....KMCTILKRIPEGAEATTVLVGAVDFLEQPTIAFVRLAEGIP....MPSITEVPIPVRFLFLLLGP.QKTDLDYHEVGRSIATLMSNEHFHDIAYTADDREELLSAIDDFLEDSIVLPPSKWERQ
Q17LT4_AEDAE/264-527             DVEEGADRWGRPHVASLSFHSLLNLRRCLETGVVLMDLEEKDLPSVAYRIVEQMVIDELIHEDDKPTIMRALLLRHRHVNE.......HSHGGFHFGPKRKYSSYSSLQSV................................DDKKPRIVPSSEINGH..GHGETKINMHEETY.....................................................................TSSQEDIKMRTQKESILKRIPEGAEATTVLVGSVDFLEQPTIAFVRLAEGIP....MPSITEVPIPVRFLFILLGP.KTAELDYHEVGRSIATLMSNEHFHDIAYRADDRKDLLSAINEFLDDSIVLPPGKWERQ
B3A3_RABIT/351-620               DVEEETERWGKPHVASLSFRSLLELRRTIAHGAALLDLEQTTLPGIAHLVVETMIVSDQIRPEDRASVLRTLLLKHCHPND........DKDCGSFPRNPSSSSVNSVLGNHH..............................ATPSHGPDGAVPTMADDLGEPAPLWPHDPDAKE..................................................................RPLHMPGGDGHRGKSLKLLEKIPEDAEATVVLVGCVPFLEQPAAAFVRLSEAVL....LESVLEVPVPVRFLFVMLGP.SHISTDYHELGRSIATLMSDKLFHEAAYQADDRQDLLGAISEFLDGSIVIPPSEVEGR
B3A2_HUMAN/352-620               DVEEETERWGKPHVASLSFRSLLELRRTLAHGAVLLDLDQQTLPGVAHQVVEQMVISDQIKAEDRANVLRALLLKHSHPSD.......EKDFS..FPRNISAGSLGSLLGHHH.............................GQGAESDPHVTEPLMGGVPETRLE..VERERELPP.................................................................PAPPAGITRSKSKHELKLLEKIPENAEATVVLVGCVEFLSRPTMAFVRLREAVE....LDAVLEVPVPVRFLFLLLGP.SSANMDYHEIGRSISTLMSDKQFHEAAYLADEREDLLTAINAFLDCSVVLPPSEVQGE
B3AT_CHICK/89-336                ESMEPGGAWG.SHLPLLTYHSLLELHRAFAKGVVLLDVAANSLAAVAHVLLDQLIYEGQLKPQHRDDVLRALLLRHKHPSE........AESVWTLPAAQLQCSDGEQKD.................................ADERALLRDQRAVEMRELHGAGQSP...................................................................................SRAQLGPQLHQQLPEDTEATLVLVACAAFLEQPLLALVRLGAPCP.....DAVLAVPLPVRFVLTVLGP.DSPRLSYHEIRRAAATVMADRVFRRDAYLCGGRAELLGGLQGFLEASIVLPPQEVPSE
B3AT_MOUSE/100-342               ENLREDGVWGRPHLSYLTFWSLLELQKVFSKGTFLLGLAETSLAGVANHLLDCFIYEDQIRPQDREELLRALLLKRSHAED.......LGNLEGVKPAVLTRSG.......................................GASEPLLPHQPSLETQLYCGQAEGG...................................................................................SEGPSTSGTL.KIPPDSETTLVLVGRANFLEKPVLGFVRLKEAVP....LEDLV.LPEPVGFLLVLLGP.EAPHVDYTQLGRAAATLMTERVFRITASMAHNREELLRSLESFLDCSLVLPPTDAPSE
Q2Z1P9_HORSE/106-345             ....EDGAWGRPHLSYLNFWSLLDLQRAFAKGSVLLDLSETSLAGVAEKLLDRFIYDGLIRPQYREDLLWVLLLKHSHARD.......LKELDGVKPTVLTPSG.......................................GTLQPLLPEHPSLETQLFCAQGEGD...................................................................................TEESSPSGILEKISPDSEAALVLVGRISFLEKPVLGFVRLREAVE....LEATVEPSVPVRFLLVLLGP.EAPHTDYTQLGRAAATLMSERVFLNEANTAQSKEELVRSLEGFLDCSLVLPPLDAPS.
Q9TUQ0_BOVIN/21-268              ENLGKDGIWGRPHLPYLNFWSLLELQKAFAKGTVLLDLPGKSLAEVANQLLDRFTFEGQIQPDDQDNLLRVLLLKHSHASD.......MEALGGVKPVVVTHSG.......................................DPSEPLLPQHPSLETELFCEQGEGS...................................................................................TRGHAPE.ILGKSPQDWEATLVLVGCARFLKRPVLGFVRLKEPMEPEPKPEGSEEPAVPVRFLIVLLGP.EGPNINYTQLGRAAATLMSERVFWNDAYLAQSKETLVQSLEGFLDCSLVLPPLDAPSE
B3AT_HUMAN/86-329                ENLGENGAWGRPHLSHLTFWSLLELRRVFTKGTVLLDLQETSLAGVANQLLDRFIFEDQIRPQDREELLRALLLKHSHAGE.......LEALGGVKPAVLTRSG.......................................DPSQPLLPQHSSLETQLFCEQGDGG...................................................................................TEGHSPSGILEKIPPDSEATLVLVGRADFLEQPVLGFVRLQEAAE....LEAV.ELPVPIRFLFVLLGP.EAPHIDYTQLGRAAATLMSERVFRIDAYMAQSRGELLHSLEGFLDCSLVLPPTDAPSE
#=GR B3AT_HUMAN/86-329     SS    EEB-TTS-B---B---EEHHHHHHHHHHHHT-EEEEEE---SHHHHHHHHHHHHHHTTSS-GGGHHHHHHHHTS-EE-HHH.......HHHHT-EEE-EE-TTS.......................................-EE--SSS-SS-HHHHHHTTTTTSS...................................................................................SSTTGGGGGGGGS-TT--EEEEEEEEETTSSS-EEEEEEEEEEE-....-TTS.SSS--EEEEEEEEE-.-BTTB-HHHHHHHHHHHHCSHHHHHHHHH-SSHHHHHHHHHHHHHT-EEE-S-SS-HH
Q1A708_STRPU/152-465             DVDVDADRWSKPHVATLPLHSLFELRTCLINGTVCLDMEADNIVQIADLVLDKLIMSEQLDESKREQVREALLRKHHHQSHKK...HRDKRGSSLLPMIRSLTDIGRSLSQGGAHNTSMEQQAAAQSGIQTSHGSSPNIQNSQTSPSSLMVKGNSGDLGKSETSGSLPKVSSHHSLKKRL..........................................................SEARLSIPHNLAGHSLSARHSFMRKIPQGAEASNVLIGEVDFLSRPIIAFVRLQSAVS....LGDPTEVPIPRRFLFILLGPQSGETKRYHEIGRCVATIMSDKVFHDVAYKAKSTKDLLAGIDEFIDSVTVLPPGAWDPN
S4A8_HUMAN/145-404               DVEDGGERWSKPYVATLSLHSLFELRSCLINGTVLLDMHANSIEEISDLILDQQELSSDLNDSMRVKVREALLKKHHHQNE........KKRNNLIPIVRSFAEVGKKQSDPHL...........................MDKHGQTVSPQSVPTTNLEVKNGVNCEHS...............................................................................PVDLSKVDLHFMKKIPTGAEASNVLVGEVDILDRPIVAFVRLSPAVL....LSGLTEVPIPTRFLFILLGP.VGKGQQYHEIGRSMATIMTDEIFHDVAYKAKERDDLLAGIDEFLDQVTVLPPGEWDPS
#=GR S4A8_HUMAN/145-404    SS    EEECCCTEE---B---EEHHHHHHHHHHHHHSEEEEEE--SSHHHHHHHHHT-TTTTSSS-HHHHHHHHHHHTS-EE-SS-........-------------------------...........................-----------------------------...............................................................................---------SSGGGS-TT-EEEEEEEEEETT-SS-EEEEEEEEEEE-....-TTTSSS---EEEEEEEEE-.TT-HHHHHHHHHHHHHHTTSHHHHHHHHH--SHHHHHHHHHHHHHH-EEE-XXXXXXX
H3DGF3_TETNG/144-400             DVEDGGERWSKPYVATLSLHSLFELRSCIFNGTVLLDMRANTIEEIADMVLDHREIYSPLGNEVRKKVRATLLKQHHHQNQ........KKLANRLPIVRSIADMGRRASELH.............................LDKSDQMTSSQSQLAGPEGKAEASKENS...............................................................................FVDFSKIDLHFMKKIPVGAEACNVLVGELDFLNRPVVAFVRLSPAVL....LSGLAEVPIATRFLFILLGP.TGRGPQYHEIGRSMATLMTDEVFHDVAYKAKDRNDLIAGIDEFLDQVTVLPPGEWDP.
#=GC SS_cons                     EEECCCTEE---B---EEHHHHHHHHHHHHCSEEEEEE--SSHHHHHHHHHCHCCCTTSS-HHHHHHHHHHHTS-EE-CCH.......HHHHT-EEE-EE-TTS----------...........................---EE--SSS-SS-HHHHHHTTTTTSS--...............................................................................--SSTTGGGCCGGGS-TT-EEEEEEEEEETTSSS-EEEEEEEEEEE-....-TTTSSSS--EEEEEEEEE-.TCTCCHHHHHHHHHHHHCCSHHHHHHHHH-SSHHHHHHHHHHHHHC-EEE-SXSSXHH
#=GC seq_cons                    -VE-tusRWG+PHVAoLSaHSLLELR+sltpGsVLLDLptsoLsslActll-phlhpsplcspcRcplhcuLLL+HpHss-........pchsshhPhspohuuhsp..u.................................ssspshhstpsshpsp.hpspspts...................................................................................sppptspphLcKIPtsuEAosVLVGpV-FL-pPllAFVRLppAl.....LsulsEVPlPlRFLFlLLGP.pu.shsYHElGRuhATLMo-clFH-sAYpAcsRc-LLuuI--FLDsSlVLPPu-h-sp
//