# STOCKHOLM 1.0 #=GF ID Band_3_cyto #=GF AC PF07565.14 #=GF DE Band 3 cytoplasmic domain #=GF AU Bateman A;0000-0002-6982-4660 #=GF SE Pfam-B_1004 (release 3.0) #=GF GA 34.30 34.30; #=GF TC 34.40 34.30; #=GF NC 34.10 34.20; #=GF BM hmmbuild HMM.ann SEED.ann #=GF SM hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq #=GF TP Domain #=GF WK Bicarbonate_transporter_proteins #=GF RN [1] #=GF RM 11049968 #=GF RT Crystallographic structure and functional interpretation of the #=GF RT cytoplasmic domain of erythrocyte membrane band 3. #=GF RA Zhang D, Kiyatkin A, Bolin JT, Low PS; #=GF RL Blood 2000;96:2925-2933. #=GF DR INTERPRO; IPR013769; #=GF DR SCOP; 1hyn; fa; #=GF DR TC; 2.A.31; #=GF DR SO; 0000417; polypeptide_domain; #=GF CC This family contains the cytoplasmic domain of the Band 3 anion #=GF CC exchange proteins that exchange Cl-/HCO3-. Band 3 constitutes #=GF CC the most abundant polypeptide in the red blood cell membrane, #=GF CC comprising 25% of the total membrane protein. The cytoplasmic #=GF CC domain of band 3 functions primarily as an anchoring site for #=GF CC other membrane-associated proteins. Included among the protein #=GF CC ligands of cdb3 are ankyrin, protein 4.2, protein 4.1, #=GF CC glyceraldehyde-3-phosphate dehydrogenase (GAPDH), #=GF CC phosphofructokinase, aldolase, hemoglobin, hemichromes, and the #=GF CC protein tyrosine kinase (p72syk). [1] #=GF SQ 16 #=GS Q29N79_DROPS/170-438 AC Q29N79.3 #=GS G5EC65_CAEEL/67-345 AC G5EC65.1 #=GS S4A5_HUMAN/141-408 AC Q9BY07.2 #=GS Q2LZ95_DROPS/294-628 AC Q2LZ95.2 #=GS Q7PT77_ANOGA/85-347 AC Q7PT77.4 #=GS Q17LT4_AEDAE/264-527 AC Q17LT4.1 #=GS B3A3_RABIT/351-620 AC O18917.1 #=GS B3A2_HUMAN/352-620 AC P04920.4 #=GS B3AT_CHICK/89-336 AC P15575.1 #=GS B3AT_MOUSE/100-342 AC P04919.1 #=GS Q2Z1P9_HORSE/106-345 AC Q2Z1P9.1 #=GS Q9TUQ0_BOVIN/21-268 AC Q9TUQ0.1 #=GS B3AT_HUMAN/86-329 AC P02730.3 #=GS B3AT_HUMAN/86-329 DR PDB; 4KY9 P; 86-329; #=GS B3AT_HUMAN/86-329 DR PDB; 1HYN S; 86-329; #=GS B3AT_HUMAN/86-329 DR PDB; 1HYN R; 86-329; #=GS B3AT_HUMAN/86-329 DR PDB; 4KY9 A; 86-329; #=GS B3AT_HUMAN/86-329 DR PDB; 1HYN Q; 86-329; #=GS B3AT_HUMAN/86-329 DR PDB; 1HYN P; 86-329; #=GS Q1A708_STRPU/152-465 AC Q1A708.1 #=GS S4A8_HUMAN/145-404 AC Q2Y0W8.1 #=GS S4A8_HUMAN/145-404 DR PDB; 5JHO B; 92-344; #=GS S4A8_HUMAN/145-404 DR PDB; 5JHO A; 92-344; #=GS H3DGF3_TETNG/144-400 AC H3DGF3.1 Q29N79_DROPS/170-438 DVEEGGNRWSKPHVATLSLHSLFELRRLLVNGTVMLDMEAPNLEVMADLVCDQMVSAGTLPPGVKDKVKDALLRRHRHQHE........YAKKTRLPIIRSLADMRNHSSSKKK............................KSNSKNLRPTQNLPVITEDMVKSPSSQSMARPS.....................................................................SGTELNDQQHKGNTHFMRKIPPGAEASNILVGEVDFLERTLSCFIRLSQAAL....MGDLTEVPVPTRFIFILLGP.PGSQSNFHEIGRAMATLMSDEIFHEVAYRARKREHLLAGVDEFLDAVTVLPPGEWDPT G5EC65_CAEEL/67-345 DVEQGGNRWSKPHVATLSLHSLFQLRSCIMNGHFMNDLAETDIPSIFNAVIENLEKSGDLPSENREELREILLRKHVHQYEQAKKNGAGGEKGGFLSTVRSISDIGKSFSHGKNL..........................SKIEEKPEGPVTSQTAGAPSGSSNQLTLPTVESV.....................................................................PKDISSEESSKGNLHFLKKLPAGVEASNVLIGEVDFLTRHICCFIRLKNANQ....LGDLTEVPVPTRFIFLLLGP.TGHGQQYREIGRAIATLMADEIFHDVAYGARDVDDLLDGIDEFLDQVTVLPPGEWDPN S4A5_HUMAN/141-408 KVEEGGERWSKPHVSTLSLHSLFELRTCLQTGTVLLDLDSGSLPQIIDDVIEKQIEDGLLRPELRERVSYVLLRRHRHQTK..............KPIHRSLADIGKSVSTTNRSPARS.................PGAGPSLHHSTEDLRMRQSANYGRLCHAQSRSMNDI...........................................................................SLTPNTDQRKNKFMKKIPKDSEASNVLVGEVDFLDQPFIAFVRLIQSAM....LGGVTEVPVPTRFLFILLGP.SGRAKSYNEIGRAIATLMVDDLFSDVAYKARNREDLIAGIDEFLDEVIVLPPGEWDPN Q2LZ95_DROPS/294-628 DVEEGSDRWGKPHVASLSFHSLLNLRRCLETGVVLLDLNEKDLPAVAYRVVEQMVIEDLIDINDKPSVMRSLLLRHRHVNE.........HQGVLPFTKRKYNSYTSLQFLWM..............................GADAQQQSLQQQQTRNLAKARRSICVTSSAPPAAAAAATTLNVGSPAGIASSIDHRRHSTMSYLGNLSGGTDDKKIKIMPAADIGGSKRSNELKIDMKDDMYSSSQEDLKKLQNDTILRRIPAGAEATTVLVGAVEFLDQPTIAFVRLSEGVM....MPTLTEVPVPVRFMFVLLGP.RNFDLDYHEVGRSISTLMANEHFHAIAYKADDRKDLLSAINEFLDDSIVLPPGNWDRH Q7PT77_ANOGA/85-347 NLEEEADRWGRPHVAALSFHSLLNLRHCLETGVVLMSLEANDLSIVAHRVVEQMVARELIHEDDKPVIARALLLRHRHVNE.......NTHGGIFYGSRRRLSSFTSIRSVKN..............................DSRKPRIIPVVEINGH.GGQSEMRLNINDESY.....................................................................TSSQEDI....KMCTILKRIPEGAEATTVLVGAVDFLEQPTIAFVRLAEGIP....MPSITEVPIPVRFLFLLLGP.QKTDLDYHEVGRSIATLMSNEHFHDIAYTADDREELLSAIDDFLEDSIVLPPSKWERQ Q17LT4_AEDAE/264-527 DVEEGADRWGRPHVASLSFHSLLNLRRCLETGVVLMDLEEKDLPSVAYRIVEQMVIDELIHEDDKPTIMRALLLRHRHVNE.......HSHGGFHFGPKRKYSSYSSLQSV................................DDKKPRIVPSSEINGH..GHGETKINMHEETY.....................................................................TSSQEDIKMRTQKESILKRIPEGAEATTVLVGSVDFLEQPTIAFVRLAEGIP....MPSITEVPIPVRFLFILLGP.KTAELDYHEVGRSIATLMSNEHFHDIAYRADDRKDLLSAINEFLDDSIVLPPGKWERQ B3A3_RABIT/351-620 DVEEETERWGKPHVASLSFRSLLELRRTIAHGAALLDLEQTTLPGIAHLVVETMIVSDQIRPEDRASVLRTLLLKHCHPND........DKDCGSFPRNPSSSSVNSVLGNHH..............................ATPSHGPDGAVPTMADDLGEPAPLWPHDPDAKE..................................................................RPLHMPGGDGHRGKSLKLLEKIPEDAEATVVLVGCVPFLEQPAAAFVRLSEAVL....LESVLEVPVPVRFLFVMLGP.SHISTDYHELGRSIATLMSDKLFHEAAYQADDRQDLLGAISEFLDGSIVIPPSEVEGR B3A2_HUMAN/352-620 DVEEETERWGKPHVASLSFRSLLELRRTLAHGAVLLDLDQQTLPGVAHQVVEQMVISDQIKAEDRANVLRALLLKHSHPSD.......EKDFS..FPRNISAGSLGSLLGHHH.............................GQGAESDPHVTEPLMGGVPETRLE..VERERELPP.................................................................PAPPAGITRSKSKHELKLLEKIPENAEATVVLVGCVEFLSRPTMAFVRLREAVE....LDAVLEVPVPVRFLFLLLGP.SSANMDYHEIGRSISTLMSDKQFHEAAYLADEREDLLTAINAFLDCSVVLPPSEVQGE B3AT_CHICK/89-336 ESMEPGGAWG.SHLPLLTYHSLLELHRAFAKGVVLLDVAANSLAAVAHVLLDQLIYEGQLKPQHRDDVLRALLLRHKHPSE........AESVWTLPAAQLQCSDGEQKD.................................ADERALLRDQRAVEMRELHGAGQSP...................................................................................SRAQLGPQLHQQLPEDTEATLVLVACAAFLEQPLLALVRLGAPCP.....DAVLAVPLPVRFVLTVLGP.DSPRLSYHEIRRAAATVMADRVFRRDAYLCGGRAELLGGLQGFLEASIVLPPQEVPSE B3AT_MOUSE/100-342 ENLREDGVWGRPHLSYLTFWSLLELQKVFSKGTFLLGLAETSLAGVANHLLDCFIYEDQIRPQDREELLRALLLKRSHAED.......LGNLEGVKPAVLTRSG.......................................GASEPLLPHQPSLETQLYCGQAEGG...................................................................................SEGPSTSGTL.KIPPDSETTLVLVGRANFLEKPVLGFVRLKEAVP....LEDLV.LPEPVGFLLVLLGP.EAPHVDYTQLGRAAATLMTERVFRITASMAHNREELLRSLESFLDCSLVLPPTDAPSE Q2Z1P9_HORSE/106-345 ....EDGAWGRPHLSYLNFWSLLDLQRAFAKGSVLLDLSETSLAGVAEKLLDRFIYDGLIRPQYREDLLWVLLLKHSHARD.......LKELDGVKPTVLTPSG.......................................GTLQPLLPEHPSLETQLFCAQGEGD...................................................................................TEESSPSGILEKISPDSEAALVLVGRISFLEKPVLGFVRLREAVE....LEATVEPSVPVRFLLVLLGP.EAPHTDYTQLGRAAATLMSERVFLNEANTAQSKEELVRSLEGFLDCSLVLPPLDAPS. Q9TUQ0_BOVIN/21-268 ENLGKDGIWGRPHLPYLNFWSLLELQKAFAKGTVLLDLPGKSLAEVANQLLDRFTFEGQIQPDDQDNLLRVLLLKHSHASD.......MEALGGVKPVVVTHSG.......................................DPSEPLLPQHPSLETELFCEQGEGS...................................................................................TRGHAPE.ILGKSPQDWEATLVLVGCARFLKRPVLGFVRLKEPMEPEPKPEGSEEPAVPVRFLIVLLGP.EGPNINYTQLGRAAATLMSERVFWNDAYLAQSKETLVQSLEGFLDCSLVLPPLDAPSE B3AT_HUMAN/86-329 ENLGENGAWGRPHLSHLTFWSLLELRRVFTKGTVLLDLQETSLAGVANQLLDRFIFEDQIRPQDREELLRALLLKHSHAGE.......LEALGGVKPAVLTRSG.......................................DPSQPLLPQHSSLETQLFCEQGDGG...................................................................................TEGHSPSGILEKIPPDSEATLVLVGRADFLEQPVLGFVRLQEAAE....LEAV.ELPVPIRFLFVLLGP.EAPHIDYTQLGRAAATLMSERVFRIDAYMAQSRGELLHSLEGFLDCSLVLPPTDAPSE #=GR B3AT_HUMAN/86-329 SS EEB-TTS-B---B---EEHHHHHHHHHHHHT-EEEEEE---SHHHHHHHHHHHHHHTTSS-GGGHHHHHHHHTS-EE-HHH.......HHHHT-EEE-EE-TTS.......................................-EE--SSS-SS-HHHHHHTTTTTSS...................................................................................SSTTGGGGGGGGS-TT--EEEEEEEEETTSSS-EEEEEEEEEEE-....-TTS.SSS--EEEEEEEEE-.-BTTB-HHHHHHHHHHHHCSHHHHHHHHH-SSHHHHHHHHHHHHHT-EEE-S-SS-HH Q1A708_STRPU/152-465 DVDVDADRWSKPHVATLPLHSLFELRTCLINGTVCLDMEADNIVQIADLVLDKLIMSEQLDESKREQVREALLRKHHHQSHKK...HRDKRGSSLLPMIRSLTDIGRSLSQGGAHNTSMEQQAAAQSGIQTSHGSSPNIQNSQTSPSSLMVKGNSGDLGKSETSGSLPKVSSHHSLKKRL..........................................................SEARLSIPHNLAGHSLSARHSFMRKIPQGAEASNVLIGEVDFLSRPIIAFVRLQSAVS....LGDPTEVPIPRRFLFILLGPQSGETKRYHEIGRCVATIMSDKVFHDVAYKAKSTKDLLAGIDEFIDSVTVLPPGAWDPN S4A8_HUMAN/145-404 DVEDGGERWSKPYVATLSLHSLFELRSCLINGTVLLDMHANSIEEISDLILDQQELSSDLNDSMRVKVREALLKKHHHQNE........KKRNNLIPIVRSFAEVGKKQSDPHL...........................MDKHGQTVSPQSVPTTNLEVKNGVNCEHS...............................................................................PVDLSKVDLHFMKKIPTGAEASNVLVGEVDILDRPIVAFVRLSPAVL....LSGLTEVPIPTRFLFILLGP.VGKGQQYHEIGRSMATIMTDEIFHDVAYKAKERDDLLAGIDEFLDQVTVLPPGEWDPS #=GR S4A8_HUMAN/145-404 SS EEECCCTEE---B---EEHHHHHHHHHHHHHSEEEEEE--SSHHHHHHHHHT-TTTTSSS-HHHHHHHHHHHTS-EE-SS-........-------------------------...........................-----------------------------...............................................................................---------SSGGGS-TT-EEEEEEEEEETT-SS-EEEEEEEEEEE-....-TTTSSS---EEEEEEEEE-.TT-HHHHHHHHHHHHHHTTSHHHHHHHHH--SHHHHHHHHHHHHHH-EEE-XXXXXXX H3DGF3_TETNG/144-400 DVEDGGERWSKPYVATLSLHSLFELRSCIFNGTVLLDMRANTIEEIADMVLDHREIYSPLGNEVRKKVRATLLKQHHHQNQ........KKLANRLPIVRSIADMGRRASELH.............................LDKSDQMTSSQSQLAGPEGKAEASKENS...............................................................................FVDFSKIDLHFMKKIPVGAEACNVLVGELDFLNRPVVAFVRLSPAVL....LSGLAEVPIATRFLFILLGP.TGRGPQYHEIGRSMATLMTDEVFHDVAYKAKDRNDLIAGIDEFLDQVTVLPPGEWDP. #=GC SS_cons EEECCCTEE---B---EEHHHHHHHHHHHHCSEEEEEE--SSHHHHHHHHHCHCCCTTSS-HHHHHHHHHHHTS-EE-CCH.......HHHHT-EEE-EE-TTS----------...........................---EE--SSS-SS-HHHHHHTTTTTSS--...............................................................................--SSTTGGGCCGGGS-TT-EEEEEEEEEETTSSS-EEEEEEEEEEE-....-TTTSSSS--EEEEEEEEE-.TCTCCHHHHHHHHHHHHCCSHHHHHHHHH-SSHHHHHHHHHHHHHC-EEE-SXSSXHH #=GC seq_cons -VE-tusRWG+PHVAoLSaHSLLELR+sltpGsVLLDLptsoLsslActll-phlhpsplcspcRcplhcuLLL+HpHss-........pchsshhPhspohuuhsp..u.................................ssspshhstpsshpsp.hpspspts...................................................................................sppptspphLcKIPtsuEAosVLVGpV-FL-pPllAFVRLppAl.....LsulsEVPlPlRFLFlLLGP.pu.shsYHElGRuhATLMo-clFH-sAYpAcsRc-LLuuI--FLDsSlVLPPu-h-sp //