Summary: Bucentaur or craniofacial development
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Bucentaur or craniofacial development Provide feedback
Bucentaur or craniofacial development protein 1 (BCNT) in ruminents has a different domain architecture to that in mouse and human. For this reason it has been used as a model for molecular evolution [1-3]. Both bovine and human BCNTs are phosphorylated by casein kinase II in vitro .
Takahashi I, Nobukuni T, Ohmori H, Kobayashi M, Tanaka S, Ohshima K, Okada N, Masui T, Hashimoto K, Iwashita S; , Gene 1998;211:387-394.: Existence of a bovine LINE repetitive insert that appears in the cDNA of bovine protein BCNT in ruminant, but not in human, genomes. PUBMED:9602175 EPMC:9602175
Iwashita S, Itoh T, Takeda H, Sugimoto Y, Takahashi I, Nobukuni T, Sezaki M, Masui T, Hashimoto K; , Gene 2001;268:59-66.: Gene organization of bovine BCNT that contains a portion corresponding to an endonuclease domain derived from an RTE-1 (Bov-B LINE), non-LTR retrotransposable element: duplication of an intramolecular repeat unit downstream of the truncated RTE-1. PUBMED:11368901 EPMC:11368901
Iwashita S, Osada N, Itoh T, Sezaki M, Oshima K, Hashimoto E, Kitagawa-Arita Y, Takahashi I, Masui T, Hashimoto K, Makalowski W; , Mol Biol Evol 2003;20:1556-1563.: A transposable element-mediated gene divergence that directly produces a novel type bovine Bcnt protein including the endonuclease domain of RTE-1. PUBMED:12832649 EPMC:12832649
Iwashita S, Nobukuni T, Tanaka S, Kobayashi M, Iwanaga T, Tamate HB, Masui T, Takahashi I, Hashimoto K; , Biochim Biophys Acta 1999;1427:408-416.: Partial nuclear localization of a bovine phosphoprotein, BCNT, that includes a region derived from a LINE repetitive sequence in Ruminantia. PUBMED:10350657 EPMC:10350657
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR011421
Vertebrate BCNT (named after Bucentaur) or human craniofacial development protein 1 (CFDP1) are characterised by an N-terminal acidic region, a central and single IR element (inverted repeat) from the retrotransposable element-1 family (RTE-1) and a highly conserved 82-amino acid region at the C terminus.
This entry represents the BCNT C-terminal domain that is also found in Drosophila YETI, a protein that binds to a microtubule-based motor kinesin-1, and the yeast SWR1-complex protein 5 (SWC5), a component of the SWR1 chromatin remodeling complex [PUBMED:16384818, PUBMED:14720462].
In the bovine genome recombination of BCNT through the IR element with a member of the retrotransposable element-1 family, leads to gene duplications, the insertion of the RTE-1 apurinic/apyrimidinic endonuclease (APE)-like domain (see INTERPRO) with the concomitant loss of the conserved C-terminal domain of BCNT and with the additional recruitment of either 2 (p97bcnt) or 3 (p97bcnt-2) C-terminal IR-elements [PUBMED:19393175].
For more information about this family, see http://www.intechopen.com/download/pdf/pdfs_id/21926
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Curation and family details
|Seed source:||Pfam-B_10149 (release 12.0)|
|Number in seed:||37|
|Number in full:||295|
|Average length of the domain:||78.80 aa|
|Average identity of full alignment:||36 %|
|Average coverage of the sequence by the domain:||26.19 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||7|
|Download:||download the raw HMM for this family|
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