Summary: Pretoxin HINT domain
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Pretoxin HINT domain Provide feedback
A member of the HINT superfamily of proteases that is usually found N-terminal to the toxin module in polymorphic toxin systems. The domain is predicted to function in releasing the toxin domain by autoproteolysis .
Zhang D, Iyer LM, Aravind L;, Nucleic Acids Res. 2011;39:4532-4552.: A novel immunity system for bacterial nucleic acid degrading toxins and its recruitment in various eukaryotic and DNA viral systems. PUBMED:21306995 EPMC:21306995
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This tab holds annotation information from the InterPro database.
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This superfamily includes Hedgehog C-terminal (Hog) autoprocessing domain and Intein (protein splicing domain) families.
The clan contains the following 7 members:Hint Hint_2 Hom_end_hint Intein_splicing PT-HINT U6-snRNA_bdg Vint
We make a range of alignments for each Pfam-A family:
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Curation and family details
|Seed source:||Blast clustering of Leptospira proteome.|
|Author:||Studholme D, Zhang D, Iyer LM, Aravind, L|
|Number in seed:||3|
|Number in full:||1678|
|Average length of the domain:||115.40 aa|
|Average identity of full alignment:||33 %|
|Average coverage of the sequence by the domain:||13.61 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 80369284 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||7|
|Download:||download the raw HMM for this family|
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the PT-HINT domain has been found. There are 1 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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