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30  structures 3078  species 0  interactions 5043  sequences 57  architectures

Family: Nucleos_tra2_C (PF07662)

Summary: Na+ dependent nucleoside transporter C-terminus

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

This is the Wikipedia entry entitled "Concentrative nucleoside transporter". More...

Concentrative nucleoside transporter Edit Wikipedia article

Nucleos_tra2_C
Identifiers
SymbolNucleos_tra2_C
PfamPF07662
InterProIPR011657
TCDB2.A.41
OPM superfamily454
OPM protein3tij

Human concentrative nucleoside transporters include SLC28A1, SLC28A2 and SLC28A3 proteins. SLC28A2 is a purine-specific Na+-nucleoside cotransporter localised to the bile canalicular membrane.[1] SLC28A1 is a Na+-dependent nucleoside transporter selective for pyrimidine nucleosides and adenosine. It also transports the anti-viral nucleoside analogues AZT and ddC.[2] This entry covers the C terminus of this family of transporters.

References

  1. ^ Che M, Ortiz DF, Arias IM (1995). "Primary structure and functional expression of a cDNA encoding the bile canalicular, purine-specific Na(+)-nucleoside cotransporter". J. Biol. Chem. 270 (23): 13596–9. PMID 7775409. {{cite journal}}: C1 control character in |pages= at position 7 (help); Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  2. ^ Huang QQ, Yao SY, Ritzel MW, Paterson AR, Cass CE, Young JD (1994). "Cloning and functional expression of a complementary DNA encoding a mammalian nucleoside transport protein". J. Biol. Chem. 269 (27): 17757–60. PMID 8027026. {{cite journal}}: C1 control character in |pages= at position 7 (help); Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
This article incorporates text from the public domain Pfam and InterPro: IPR011657

This page is based on a Wikipedia article. The text is available under the Creative Commons Attribution/Share-Alike License.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Na+ dependent nucleoside transporter C-terminus Provide feedback

This family consists of nucleoside transport proteins. Q62773 is a purine-specific Na+-nucleoside cotransporter localised to the bile canalicular membrane [1]. Q62674 is a a Na+-dependent nucleoside transporter selective for pyrimidine nucleosides and adenosine it also transports the anti-viral nucleoside analogues AZT and ddC [2]. This alignment covers the C-terminus of this family of transporters.

Literature references

  1. Che M, Ortiz DF, Arias IM; , J Biol Chem 1995;270:13596-13599.: Primary structure and functional expression of a cDNA encoding the bile canalicular, purine-specific Na(+)-nucleoside cotransporter. PUBMED:7775409 EPMC:7775409

  2. Huang QQ, Yao SY, Ritzel MW, Paterson AR, Cass CE, Young JD; , J Biol Chem 1994;269:17757-17760.: Cloning and functional expression of a complementary DNA encoding a mammalian nucleoside transport protein. PUBMED:8027026 EPMC:8027026


Internal database links

External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR011657

The concentrative nucleoside transporter (CNT) (TC 2.A.41) family includes SWISSPROT , which is a purine-specific Na + -nucleoside cotransporter localised to the bile canalicular membrane [ PUBMED:7775409 ]. It also includes SWISSPROT , a Na + -dependent nucleoside transporter selective for pyrimidine nucleosides and adenosine, which also transports the anti-viral nucleoside analogues AZT and ddC [ PUBMED:8027026 ].

This entry covers the C terminus of this family of transporters.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

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We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(321)
Full
(5043)
Representative proteomes UniProt
(23798)
RP15
(789)
RP35
(2227)
RP55
(4645)
RP75
(7969)
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PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(321)
Full
(5043)
Representative proteomes UniProt
(23798)
RP15
(789)
RP35
(2227)
RP55
(4645)
RP75
(7969)
Alignment:
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Sequence:
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We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(321)
Full
(5043)
Representative proteomes UniProt
(23798)
RP15
(789)
RP35
(2227)
RP55
(4645)
RP75
(7969)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Yeats C
Previous IDs: none
Type: Family
Sequence Ontology: SO:0100021
Author: Bashton M , Bateman A , Yeats C
Number in seed: 321
Number in full: 5043
Average length of the domain: 207.6 aa
Average identity of full alignment: 36 %
Average coverage of the sequence by the domain: 42.93 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 32.3 32.3
Trusted cut-off 32.9 33.0
Noise cut-off 31.7 32.2
Model length: 213
Family (HMM) version: 16
Download: download the raw HMM for this family

Species distribution

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Archea Archea Eukaryota Eukaryota
Bacteria Bacteria Other sequences Other sequences
Viruses Viruses Unclassified Unclassified
Viroids Viroids Unclassified sequence Unclassified sequence

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Nucleos_tra2_C domain has been found. There are 30 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A077ZA13 View 3D Structure Click here
A0A077ZK41 View 3D Structure Click here
A0A0D2HA53 View 3D Structure Click here
A0A0H3GL94 View 3D Structure Click here
A0A0H3GMX1 View 3D Structure Click here
A0A0H3H172 View 3D Structure Click here
A0A0K0E4U4 View 3D Structure Click here
A0A131MBV2 View 3D Structure Click here
A0A175VXY7 View 3D Structure Click here
A0A1C1CNQ7 View 3D Structure Click here
A0A1D8PHJ7 View 3D Structure Click here
A0A2R8QIQ7 View 3D Structure Click here
A1Z7N3 View 3D Structure Click here
A2AWR5 View 3D Structure Click here
C1H2I3 View 3D Structure Click here
E9PXX9 View 3D Structure Click here
G5EE77 View 3D Structure Click here
O00337 View 3D Structure Click here
O25792 View 3D Structure Click here
O32115 View 3D Structure Click here
O43868 View 3D Structure Click here
O62667 View 3D Structure Click here
O88627 View 3D Structure Click here
P0AFF2 View 3D Structure Click here
P33021 View 3D Structure Click here
P33024 View 3D Structure Click here
P39141 View 3D Structure Click here
P42312 View 3D Structure Click here
P44742 View 3D Structure Click here
Q2G0P9 View 3D Structure Click here
Q2G162 View 3D Structure Click here
Q2G2E4 View 3D Structure Click here
Q32DF1 View 3D Structure Click here
Q32EQ9 View 3D Structure Click here
Q62674 View 3D Structure Click here
Q62773 View 3D Structure Click here
Q7K4A1 View 3D Structure Click here
Q8VIH3 View 3D Structure Click here
Q8ZNA0 View 3D Structure Click here
Q9ERH8 View 3D Structure Click here