Summary: BTB And C-terminal Kelch
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BTB And C-terminal Kelch Provide feedback
This domain is found associated with PF00651 and PF01344 . The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues . This family appears to be closely related to the BTB domain (Finn RD, personal observation).
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR011705
This domain is found associated with (INTERPRO) and (INTERPRO). BTB (broad-complex, tramtrack and bric a brac) is a Kelch related domain, also known as the POZ domain [PUBMED:16207353]. BTB proteins are divided into subgroups depending on what domain lies at the C terminus. Despite the divergence in sequences, the BTB fold is highly conserved.
BTB-Kelch proteins have Kelch repeats that form a beta-propeller that can interact with actin filaments [PUBMED:15544948]. BTB and C-terminal Kelch (BACK) together constitute a novel conserved domain, which is thought to have a possible role in substrate orientation in Cullin3-based E3 ligase complexes.
Four domains, namely the BTB domain, a kelch domain, a BACK domain, and an intervening region (IVR) make up the aryl hydrocarbon receptor (AHR); a ligand-activated transcription factor [PUBMED:16582008]. This entry represents the domain associated with BTB and Kelch.
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The POZ domain is found in a variety of transcription factors. POZ domains are also found in the tetramerisation domain of voltage gated K+ channels. In general these domains mediate homo-oligomerisation.
The clan contains the following 5 members:BACK BTB BTB_2 DUF3342 Skp1_POZ
We make a range of alignments for each Pfam-A family:
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Curation and family details
|Seed source:||Stogios PJ|
|Author:||Stogios PJ, Studholme DJ, Finn RD|
|Number in seed:||81|
|Number in full:||5713|
|Average length of the domain:||98.70 aa|
|Average identity of full alignment:||24 %|
|Average coverage of the sequence by the domain:||18.96 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||10|
|Download:||download the raw HMM for this family|
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the BACK domain has been found. There are 7 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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