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10  structures 685  species 0  interactions 26358  sequences 752  architectures

Family: BACK (PF07707)

Summary: BTB And C-terminal Kelch

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

The Pfam group coordinates the annotation of Pfam families in Wikipedia, but we have not yet assigned a Wikipedia article to this family. If you think that a particular Wikipedia article provides good annotation, please let us know.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

BTB And C-terminal Kelch Provide feedback

This domain is found associated with PF00651 and PF01344 [1]. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues [1]. This family appears to be closely related to the BTB domain (Finn RD, personal observation).

Literature references

  1. Stogios PJ, Prive GG; , Trends Biochem Sci 2004;29:634-637.: The BACK domain in BTB-kelch proteins. PUBMED:15544948 EPMC:15544948


Internal database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR011705

This domain is found associated with ( INTERPRO ) and ( INTERPRO ). BTB (broad-complex, tramtrack and bric a brac) is a Kelch related domain, also known as the POZ domain [ PUBMED:16207353 ]. BTB proteins are divided into subgroups depending on what domain lies at the C terminus. Despite the divergence in sequences, the BTB fold is highly conserved.

BTB-Kelch proteins have Kelch repeats that form a beta-propeller that can interact with actin filaments [ PUBMED:15544948 ]. BTB and C-terminal Kelch (BACK) together constitute a novel conserved domain, which is thought to have a possible role in substrate orientation in Cullin3-based E3 ligase complexes.

Four domains, namely the BTB domain, a kelch domain, a BACK domain, and an intervening region (IVR) make up the aryl hydrocarbon receptor (AHR); a ligand-activated transcription factor [ PUBMED:16582008 ]. This entry represents the domain associated with BTB and Kelch.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Pfam Clan

This family is a member of clan POZ (CL0033), which has the following description:

The POZ domain is found in a variety of transcription factors. POZ domains are also found in the tetramerisation domain of voltage gated K+ channels. In general these domains mediate homo-oligomerisation.

The clan contains the following 6 members:

BACK BTB BTB_2 BTB_3 DUF3342 Skp1_POZ

Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(64)
Full
(26358)
Representative proteomes UniProt
(47639)
RP15
(6665)
RP35
(11831)
RP55
(23242)
RP75
(29760)
Jalview View  View  View  View  View  View  View 
HTML View             
PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(64)
Full
(26358)
Representative proteomes UniProt
(47639)
RP15
(6665)
RP35
(11831)
RP55
(23242)
RP75
(29760)
Alignment:
Format:
Order:
Sequence:
Gaps:
Download/view:

Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(64)
Full
(26358)
Representative proteomes UniProt
(47639)
RP15
(6665)
RP35
(11831)
RP55
(23242)
RP75
(29760)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Stogios PJ
Previous IDs: none
Type: Domain
Sequence Ontology: SO:0000417
Author: Stogios PJ , Studholme DJ , Finn RD
Number in seed: 64
Number in full: 26358
Average length of the domain: 97.40 aa
Average identity of full alignment: 21 %
Average coverage of the sequence by the domain: 17.19 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 20.9 20.9
Trusted cut-off 20.9 20.9
Noise cut-off 20.8 20.8
Model length: 103
Family (HMM) version: 17
Download: download the raw HMM for this family

Species distribution

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Selections

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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the BACK domain has been found. There are 10 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A0G2K102 View 3D Structure Click here
A0A0G2K427 View 3D Structure Click here
A0A0G2K533 View 3D Structure Click here
A0A0G2K982 View 3D Structure Click here
A0A0G2K9E3 View 3D Structure Click here
A0A0G2KCH4 View 3D Structure Click here
A0A0N4STP4 View 3D Structure Click here
A0A0N7KEH2 View 3D Structure Click here
A0A0R0ECU3 View 3D Structure Click here
A0A0R0EIF6 View 3D Structure Click here
A0A0R0ES85 View 3D Structure Click here
A0A0R0EUE4 View 3D Structure Click here
A0A0R0EV96 View 3D Structure Click here
A0A0R0GGE3 View 3D Structure Click here
A0A0R4IAE5 View 3D Structure Click here
A0A0R4IV61 View 3D Structure Click here
A0A140LGQ1 View 3D Structure Click here
A0A140LGZ3 View 3D Structure Click here
A0A1D6H591 View 3D Structure Click here
A0A286YC09 View 3D Structure Click here
A0A2C9C3D9 View 3D Structure Click here
A0A2I3BRZ3 View 3D Structure Click here
A0A2R8PXW6 View 3D Structure Click here
A0A2R8Q0Z4 View 3D Structure Click here
A0A2R8Q1W5 View 3D Structure Click here
A0A2R8Q260 View 3D Structure Click here
A0A2R8Q5T3 View 3D Structure Click here
A0A2R8Q616 View 3D Structure Click here
A0A2R8Q9E7 View 3D Structure Click here
A0A2R8QB83 View 3D Structure Click here
A0A2R8QCY5 View 3D Structure Click here
A0A2R8QD64 View 3D Structure Click here
A0A2R8QFR8 View 3D Structure Click here
A0A2R8QS60 View 3D Structure Click here
A0A2R8QUM7 View 3D Structure Click here
A0A2R8RYY7 View 3D Structure Click here
A1Z7I5 View 3D Structure Click here
A2AAX3 View 3D Structure Click here
A2AJX0 View 3D Structure Click here
A2AUC9 View 3D Structure Click here
A2RRV4 View 3D Structure Click here
A6NCF5 View 3D Structure Click here
A6NE02 View 3D Structure Click here
A9JRD8 View 3D Structure Click here
B0S619 View 3D Structure Click here
B1AZR0 View 3D Structure Click here
B1H285 View 3D Structure Click here
B3DIV9 View 3D Structure Click here
B5DEL5 View 3D Structure Click here
B8JIG8 View 3D Structure Click here
B8JJT0 View 3D Structure Click here
B8JKQ2 View 3D Structure Click here
C0HG55 View 3D Structure Click here
C9JJ37 View 3D Structure Click here
D3Z860 View 3D Structure Click here
D3Z8N4 View 3D Structure Click here
D3ZA50 View 3D Structure Click here
D3ZH92 View 3D Structure Click here
D3ZHA2 View 3D Structure Click here
D3ZHE1 View 3D Structure Click here
D3ZHI3 View 3D Structure Click here
D3ZJC0 View 3D Structure Click here
D3ZLT6 View 3D Structure Click here
D3ZLV9 View 3D Structure Click here
D3ZPJ1 View 3D Structure Click here
D3ZRI9 View 3D Structure Click here
D3ZVS6 View 3D Structure Click here
D3ZY10 View 3D Structure Click here
D3ZYQ7 View 3D Structure Click here
D3ZZC3 View 3D Structure Click here
D4A1F4 View 3D Structure Click here
D4A1Z1 View 3D Structure Click here
D4A2K4 View 3D Structure Click here
D4A6V5 View 3D Structure Click here
D4A7F5 View 3D Structure Click here
D4A8L9 View 3D Structure Click here
D4A9J8 View 3D Structure Click here
D4AA43 View 3D Structure Click here
D4AC05 View 3D Structure Click here
D4AEF4 View 3D Structure Click here
E0CZ16 View 3D Structure Click here
E7EZB5 View 3D Structure Click here
E7F464 View 3D Structure Click here
E7F5R6 View 3D Structure Click here
E7F6F9 View 3D Structure Click here
E7F8E3 View 3D Structure Click here
E7FCD9 View 3D Structure Click here
E7FED5 View 3D Structure Click here
E7FH32 View 3D Structure Click here
E9PUS2 View 3D Structure Click here
E9PYD7 View 3D Structure Click here
E9Q4F2 View 3D Structure Click here
E9QC48 View 3D Structure Click here
E9QC58 View 3D Structure Click here
E9QDY6 View 3D Structure Click here
E9QHN1 View 3D Structure Click here
E9QHV0 View 3D Structure Click here
E9QIN8 View 3D Structure Click here
E9QJ30 View 3D Structure Click here
F1LM44 View 3D Structure Click here
F1LZ52 View 3D Structure Click here
F1LZF0 View 3D Structure Click here
F1M311 View 3D Structure Click here
F1M3S0 View 3D Structure Click here
F1M601 View 3D Structure Click here
F1M7U0 View 3D Structure Click here
F1M9S9 View 3D Structure Click here
F1Q6J6 View 3D Structure Click here
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G5ED84 View 3D Structure Click here
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G5EGS4 View 3D Structure Click here
H2KYJ3 View 3D Structure Click here
I1JRW6 View 3D Structure Click here
I1KI09 View 3D Structure Click here
I1MKP3 View 3D Structure Click here
I1NCH4 View 3D Structure Click here
K7KFZ2 View 3D Structure Click here
K7LML5 View 3D Structure Click here
K7V570 View 3D Structure Click here
M0R4Q5 View 3D Structure Click here
O04615 View 3D Structure Click here
O14682 View 3D Structure Click here
O16313 View 3D Structure Click here
O35709 View 3D Structure Click here
O60662 View 3D Structure Click here
O61366 View 3D Structure Click here
O61795 View 3D Structure Click here
O70513 View 3D Structure Click here
O82343 View 3D Structure Click here
O94889 View 3D Structure Click here
O95198 View 3D Structure Click here
P28575 View 3D Structure Click here
P57790 View 3D Structure Click here
P58544 View 3D Structure Click here
P58545 View 3D Structure Click here
P59280 View 3D Structure Click here
Q07797 View 3D Structure Click here
Q08380 View 3D Structure Click here
Q08BL9 View 3D Structure Click here
Q08CL1 View 3D Structure Click here
Q08CL3 View 3D Structure Click here
Q09563 View 3D Structure Click here
Q0D2K2 View 3D Structure Click here
Q10579 View 3D Structure Click here
Q13939 View 3D Structure Click here
Q14145 View 3D Structure Click here
Q1ECZ2 View 3D Structure Click here
Q1EG90 View 3D Structure Click here
Q1LUF9 View 3D Structure Click here
Q1LXS8 View 3D Structure Click here
Q1LYM6 View 3D Structure Click here
Q20183 View 3D Structure Click here
Q24JV9 View 3D Structure Click here
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Q3U410 View 3D Structure Click here
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Q3ZB90 View 3D Structure Click here
Q3ZCT8 View 3D Structure Click here
Q4KLM4 View 3D Structure Click here
Q503R4 View 3D Structure Click here
Q53G59 View 3D Structure Click here
Q53GT1 View 3D Structure Click here
Q53HC5 View 3D Structure Click here
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Q54F31 View 3D Structure Click here
Q56A24 View 3D Structure Click here
Q5BK60 View 3D Structure Click here
Q5PQR3 View 3D Structure Click here
Q5RG82 View 3D Structure Click here
Q5RGB8 View 3D Structure Click here
Q5RKI2 View 3D Structure Click here
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Q5TZE1 View 3D Structure Click here
Q5U374 View 3D Structure Click here
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Q5XHZ6 View 3D Structure Click here
Q5XI58 View 3D Structure Click here
Q5Z9M6 View 3D Structure Click here
Q66HD2 View 3D Structure Click here
Q69ZK5 View 3D Structure Click here
Q6DEL7 View 3D Structure Click here
Q6DKY8 View 3D Structure Click here
Q6GKZ1 View 3D Structure Click here
Q6GQU2 View 3D Structure Click here
Q6JEL2 View 3D Structure Click here
Q6JEL3 View 3D Structure Click here
Q6K229 View 3D Structure Click here
Q6NY73 View 3D Structure Click here
Q6NYM1 View 3D Structure Click here
Q6PF15 View 3D Structure Click here
Q6PFE1 View 3D Structure Click here
Q6Q7X9 View 3D Structure Click here
Q6TDP3 View 3D Structure Click here
Q6TDP4 View 3D Structure Click here
Q6TFL4 View 3D Structure Click here
Q6V595 View 3D Structure Click here
Q6ZPT1 View 3D Structure Click here
Q75JX5 View 3D Structure Click here
Q7JWV5 View 3D Structure Click here
Q7K0L2 View 3D Structure Click here
Q7K187 View 3D Structure Click here
Q7KSF5 View 3D Structure Click here
Q7ZT06 View 3D Structure Click here
Q7ZVQ8 View 3D Structure Click here
Q80T74 View 3D Structure Click here
Q80TF4 View 3D Structure Click here
Q86V97 View 3D Structure Click here
Q8BGY4 View 3D Structure Click here
Q8BHI4 View 3D Structure Click here
Q8BRG6 View 3D Structure Click here
Q8BSF5 View 3D Structure Click here
Q8BUL5 View 3D Structure Click here
Q8BWA5 View 3D Structure Click here
Q8BZM0 View 3D Structure Click here
Q8C3F7 View 3D Structure Click here
Q8C726 View 3D Structure Click here
Q8CA72 View 3D Structure Click here
Q8CDE2 View 3D Structure Click here
Q8CE33 View 3D Structure Click here
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Q8IXQ5 View 3D Structure Click here
Q8IY47 View 3D Structure Click here
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Q8K430 View 3D Structure Click here
Q8LEV3 View 3D Structure Click here
Q8N239 View 3D Structure Click here
Q8N4N3 View 3D Structure Click here
Q8NAB2 View 3D Structure Click here
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Q8NFY9 View 3D Structure Click here
Q8R124 View 3D Structure Click here
Q8R179 View 3D Structure Click here
Q8R2H4 View 3D Structure Click here
Q8R2P1 View 3D Structure Click here
Q8S8F2 View 3D Structure Click here
Q8VCK5 View 3D Structure Click here
Q8WQC4 View 3D Structure Click here
Q8WVZ9 View 3D Structure Click here
Q8WZ60 View 3D Structure Click here
Q920G9 View 3D Structure Click here
Q920Q8 View 3D Structure Click here
Q93289 View 3D Structure Click here
Q96CT2 View 3D Structure Click here
Q96IK5 View 3D Structure Click here
Q96KE9 View 3D Structure Click here
Q96M94 View 3D Structure Click here
Q96NJ5 View 3D Structure Click here
Q96PQ7 View 3D Structure Click here
Q96Q07 View 3D Structure Click here
Q99JN2 View 3D Structure Click here
Q9BX70 View 3D Structure Click here
Q9C0H6 View 3D Structure Click here
Q9CR40 View 3D Structure Click here
Q9CZ49 View 3D Structure Click here
Q9D5V2 View 3D Structure Click here
Q9D618 View 3D Structure Click here
Q9D783 View 3D Structure Click here
Q9DB72 View 3D Structure Click here
Q9ER30 View 3D Structure Click here
Q9FPW6 View 3D Structure Click here
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Q9H0H3 View 3D Structure Click here
Q9H2C0 View 3D Structure Click here
Q9H511 View 3D Structure Click here
Q9JI74 View 3D Structure Click here
Q9NR64 View 3D Structure Click here
Q9NVR0 View 3D Structure Click here
Q9NVX7 View 3D Structure Click here
Q9NXS3 View 3D Structure Click here
Q9P203 View 3D Structure Click here
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Q9P2J3 View 3D Structure Click here
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Q9UAQ7 View 3D Structure Click here
Q9UH77 View 3D Structure Click here
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Q9VR80 View 3D Structure Click here
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Q9VU26 View 3D Structure Click here
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Q9W593 View 3D Structure Click here
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Q9Y573 View 3D Structure Click here
Q9Y6Y0 View 3D Structure Click here
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S4R1I0 View 3D Structure Click here
X1WD22 View 3D Structure Click here
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X1WG55 View 3D Structure Click here